Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 159, Issue -, Pages 133-141Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2016.02.020
Keywords
Synthesis; Arene ruthenium(II) complexes; Lipophilicity; Cytotoxic effect
Funding
- Medical University of Lodz [503/3-066-02/503-31-001, 503/1-156-01/503-11-001]
- [502-03/3-066-02/502-34-025]
- [503/3-066-02/503-06-300]
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A series of arene ruthenium(II) complexes with the general formula [(eta(6) - arene)Ru(L)X-2] (where arene = p-cymene, benzene, hexamethylbenzene or mesitylene, L = aminoflavone or aminochromone derivatives and X = Cl, I) were synthesized and characterized by elemental analysis, MS, IR and H-1 NMR spectroscopy. The stability of the selected complexes was assessed by UV-Vis spectroscopy in 24-hour period. The lipophilicity of the synthesized complexes was determined by the shake-flask method, and their cytotoxicity evaluated in vitro on patient derived melanoma populations. The most active complexes against melanoma cells contain 7-aminoflavone and 6-aminoflavone as a ligand. The relationship between the cytotoxicity of all the obtained compounds and their logP values was determined and briefly analyzed with two different patterns observed. (C) 2016 Elsevier Inc. All rights reserved.
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