Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 155, Issue -, Pages 17-25Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2015.11.010
Keywords
Dioxidovanadium(V); Heterometallic complex; X-ray structure; Antiproliferative agent
Funding
- Foundation for Science and Technology (FCT), Portugal [PTDC/EQU-EQU/122025/2010, UID/QUI/00100/2013]
- FCT, Portugal [SFRH/BPD/86067/2012]
- project Silence is golden (siAu) - silencing the silencers via multifunctional gold nanoconjugates towards cancer therapy [PTDC/BBB-NAN/1812/2012, UID/Multi/04378/2013]
Ask authors/readers for more resources
Two water soluble heterometallic potassium-dioxidovanadium polymers, [KVO2(L-1)](n) (1) and [KVO2(L-2)(H2O)](n) (2) [H2L1 = (2,3-dihydroxybenzylidene)-2-hydroxybenzohydrazide and H2L2 = (2,3-dihydroxybenzylidene)benzohydrazide], have been synthesized and characterized by IR, NMR, elemental analysis and single crystal X-ray diffraction. The antiproliferative potentials of 1 and 2 were examined towards human colorectal carcinoma (HCT116), and lung (A549) and breast (MCF7) adenocarcinoma cell lines. 1 exhibits a high cytotoxic activity against colorectal carcinoma cells (HCT116), with IC50 lower than those for cisplatin. (C) 2015 Elsevier Inc All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
