A trimeric immunoglobin G-binding domain outperforms recombinant protein G and protein L as a ligand for fragment antigen-binding purification

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64Cu-labeled daratumumab F(ab′)2 fragment enables early visualization of CD38-positive lymphoma

Lei Kang et al.

Summary: The study successfully developed Cu-64-labeled Dara-F(ab ')(2) with high tumor uptake for visualization of CD38 in lymphoma models. [Cu-64]Cu-NOTA-Dara-F(ab ')(2) demonstrated rapid and high tumor uptake, promising as a potential PET imaging agent for future clinical applications. The specific binding ability and favorable imaging contrast of [Cu-64]Cu-NOTA-Dara-F(ab ')(2) were confirmed through in vitro assays and small animal PET imaging.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022)

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Antibodies to watch in 2022

Helene Kaplon et al.

Summary: This article provides a summary of key events in the development of commercial antibody therapeutics in 2021 and a glimpse into potential events in 2022. The regulatory review process for antibody therapeutics targeting the SARS-CoV-2 coronavirus has been expedited, leading to emergency use authorizations and full approvals in multiple countries. Additionally, the late-stage commercial clinical pipeline for antibody therapeutics, excluding those for COVID-19, has seen significant growth over the past year.

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Computational Engineering of Protein L to Achieve an Optimal Affinity Chromatography Resin for Purification of Antibody Fragments

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A trimeric immunoglobin G-binding domain outperforms recombinant protein G and protein L as a ligand for fragment antigen-binding purification

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