Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 161, Issue -, Pages 115-121Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2016.05.010
Keywords
Binding constant; Circular dichroism; Computational chemistry; DNA G-quadruplex, nickel zinc
Funding
- Mahlke-Obermann Stiftung
- European Union [609431]
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Novel nickel(II) (1) and zinc(II) (2) complexes of a Salen-like ligand, carrying a pyrimidine ring on the N,N' bridge, were synthesized and characterized. Their interaction with duplex and G-quadruplex DNA was investigated in aqueous solution through UV-visible absorption, circular dichroism and viscometry measurements. The results obtained point out that, while the zinc(II) complex does not interact with both duplex and G-quadruplex DNA, the nickel(II) complex 1 binds preferentially to G-quadruplex respect to duplex-DNA, with values of the DNA-binding constants, K-b, 2.6 x 10(5) M-1 and 3.5 x 10(4) M-1, respectively. Molecular dynamics simulations provided an atomic level model of the top-stacking binding occurring between 1 and hTelo (a 22-mer sequence oligonucleotide) in G-quadruplex conformation. (C) 2016 Elsevier Inc. All rights reserved.
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