Chromatographic supports for enantioselective liquid chromatography: Evolution and innovative trends

Diverse approaches have been explored as chromatographic supports for chiral stationary phases (CSPs) in liquid chromatography (LC), such as the introduction of nanoparticles, superficially porous particles, and new materials including monoliths, metal-organic frameworks, covalent-organic frameworks as well as hybrid chromatographic supports. Nevertheless, silica-based CSPs are still nowadays the most success-fully and widely applied. In this review, the most relevant achievements related with chromatographic supports used for development of CSPs for LC are described. The advantages and drawbacks of the differ-ent materials used as chromatographic supports are critically discussed. Some recent examples of appli-cations are also presented, emphasizing innovative trends in LC.(c) 2022 Elsevier B.V. All rights reserved.

Automated summary

This review presents the latest advancements in chromatographic supports used for the development of chiral stationary phases (CSPs) in liquid chromatography (LC), with a focus on the advantages and drawbacks of different materials used as chromatographic supports. Recent application examples are also highlighted, emphasizing innovative trends in LC.