Related references
Note: Only part of the references are listed.Shape shifting: The multiple conformational substates of the PTEN N-terminal PIP2-binding domain
Jennifer E. Dawson et al.
PROTEIN SCIENCE (2022)
Conformational Preferences of an Intrinsically Disordered Protein Domain: A Case Study for Modern Force Fields
Srinivasa M. Gopal et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2021)
The structural basis of PTEN regulation by multi-site phosphorylation
Daniel R. Dempsey et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2021)
Hinge-shift mechanism as a protein design principle for the evolution of β-lactamases from substrate promiscuity to specificity
Tushar Modi et al.
NATURE COMMUNICATIONS (2021)
The mechanism of full activation of tumor suppressor PTEN at the phosphoinositide-enriched membrane
Hyunbum Jang et al.
ISCIENCE (2021)
A scalable Drosophila assay for clinical interpretation of human PTEN variants in suppression of PI3K/AKT induced cellular proliferation
Payel W. Ganguly et al.
PLOS GENETICS (2021)
Analysis of Site-Specific Phosphorylation of PTEN by Using Enzyme-Catalyzed Expressed Protein Ligation
Samuel H. Henager et al.
CHEMBIOCHEM (2020)
Structural Mechanisms of PTEN Regulation
Glenn R. Masson et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2020)
The Role of Conformational Dynamics and Allostery in Modulating Protein Evolution
Paul Campitelli et al.
ANNUAL REVIEW OF BIOPHYSICS, VOL 49, 2020 (2020)
The accuracy of force fields on the simulation of intrinsically disordered proteins: A benchmark test on the human p53 tumor suppressor
Shangbo Ning et al.
JOURNAL OF THEORETICAL & COMPUTATIONAL CHEMISTRY (2020)
Phosphorylation regulates the binding of intrinsically disordered proteins via a flexible conformation selection mechanism
Na Liu et al.
COMMUNICATIONS CHEMISTRY (2020)
Essential site scanning analysis: A new approach for detecting sites that modulate the dispersion of protein global motions
Burak T. Kaynak et al.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2020)
Dynamics and structural stability effects of germline PTEN mutations associated with cancer versus autism phenotypes
Iris Nira Smith et al.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2019)
Molecular Dynamics Simulations Combined with Nuclear Magnetic Resonance and/or Small-Angle X-ray Scattering Data for Characterizing Intrinsically Disordered Protein Conformational Ensembles
Maud Chan-Yao-Chong et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2019)
Conformational Dynamics and Allosteric Regulation Landscapes of Germline PTEN Mutations Associated with Autism Compared to Those Associated with Cancer
Iris Nira Smith et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2019)
A126 in the active site and TI167/168 in the TI loop are essential determinants of the substrate specificity of PTEN
Michael G. Leitner et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2018)
Multiplex assessment of protein variant abundance by massively parallel sequencing
Kenneth A. Matreyek et al.
NATURE GENETICS (2018)
Ancient thioredoxins evolved to modern-day stability-function requirement by altering native state ensemble
Tushar Modi et al.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2018)
PTEN Physically Interacts with and Regulates E2F1-mediated Transcription in Lung Cancer
Prerna Malaney et al.
CELL CYCLE (2018)
Cross-linking mass spectrometry: methods and applications in structural, molecular and systems biology
Francis J. O'Reilly et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)
Brain Development and Akt Signaling: the Crossroads of Signaling Pathway and Neurodevelopmental Diseases
Long Wang et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2017)
CHARMM36m: an improved force field for folded and intrinsically disordered proteins
Jing Huang et al.
NATURE METHODS (2017)
Improved Method for the Identification and Validation of Allosteric Sites
Kun Song et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2017)
Applications of NMR and computational methodologies to study protein dynamics
Chitra Narayanan et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2017)
CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field
Jumin Lee et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2016)
Crosslinking and Mass Spectrometry: An Integrated Technology to Understand the Structure and Function of Molecular Machines
Alexander Leitner et al.
TRENDS IN BIOCHEMICAL SCIENCES (2016)
Conformational Stability and Catalytic Activity of PTEN Variants Linked to Cancers and Autism Spectrum Disorders
Sean B. Johnston et al.
BIOCHEMISTRY (2015)
Identification of intrinsically disordered regions in PTEN and delineation of its function via a network approach
Prerna Malaney et al.
METHODS (2015)
Membrane association of the PTEN tumor suppressor: Neutron scattering and MD simulations reveal the structure of protein-membrane complexes
Hirsh Nanda et al.
METHODS (2015)
Intrinsically disordered proteins in cellular signalling and regulation
Peter E. Wright et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)
I-TASSER server: new development for protein structure and function predictions
Jianyi Yang et al.
NUCLEIC ACIDS RESEARCH (2015)
Conformational propensities of intrinsically disordered proteins influence the mechanism of binding and folding
Munehito Arai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Superdomains in the protein structure hierarchy: The case of PTP-C2
Donald T. Haynie et al.
PROTEIN SCIENCE (2015)
Opening the conformation is a master switch for the dual localization and phosphatase activity of PTEN
Hoai-Nghia Nguyen et al.
SCIENTIFIC REPORTS (2015)
PTEN
Carolyn A. Worby et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 83 (2014)
Mechanism of human PTEN localization revealed by heterologous expression in Dictyostelium
H. N. Nguyen et al.
ONCOGENE (2014)
Engineering ePTEN, an enhanced PTEN with increased tumor suppressor activities
Hoai-Nghia Nguyen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Engineering of Flexible Loops in Enzymes
Bettina M. Nestl et al.
ACS CATALYSIS (2014)
ATPase Subdomain IA Is a Mediator of Interdomain Allostery in Hsp70 Molecular Chaperones
Ignacio J. General et al.
PLOS COMPUTATIONAL BIOLOGY (2014)
Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments
G. Madhavi Sastry et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2013)
Intrinsic Disorder in PTEN and its Interactome Confers Structural Plasticity and Functional Versatility
Prerna Malaney et al.
SCIENTIFIC REPORTS (2013)
Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis
David Bolduc et al.
ELIFE (2013)
Membrane association of the PTEN tumor suppressor: Electrostatic interaction with phosphatidylserine-containing bilayers and regulatory role of the C-terminal tail
Siddharth S. Shenoy et al.
JOURNAL OF STRUCTURAL BIOLOGY (2012)
Ordered Phosphorylation Events in Two Independent Cascades of the PTEN C-tail Revealed by NMR
Florence Cordier et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
A Clinical Scoring System for Selection of Patients for PTEN Mutation Testing Is Proposed on the Basis of a Prospective Study of 3042 Probands
Min-Han Tan et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2011)
ProDy: Protein Dynamics Inferred from Theory and Experiments
Ahmet Bakan et al.
BIOINFORMATICS (2011)
Biophysical and Computational Studies of Membrane Penetration by the GRP1 Pleckstrin Homology Domain
Craig N. Lumb et al.
STRUCTURE (2011)
Unique biochemical properties of the protein tyrosine phosphatase activity of PTEN-Demonstration of different active site structural requirements for phosphopeptide and phospholipid phosphatase activities of PTEN
Joel Yeong-Chit Chia et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2010)
Understanding the stereospecific interactions of 3-deoxyphosphatidylinositol derivatives with the PTEN phosphatase domain
Qin Wang et al.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2010)
fpocket: online tools for protein ensemble pocket detection and tracking
Peter Schmidtke et al.
NUCLEIC ACIDS RESEARCH (2010)
Rapid E2-E3 Assembly and Disassembly Enable Processive Ubiquitylation of Cullin-RING Ubiquitin Ligase Substrates
Gary Kleiger et al.
CELL (2009)
A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN
Meghdad Rahdar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Perturbation-Response Scanning Reveals Ligand Entry-Exit Mechanisms of Ferric Binding Protein
Canan Atilgan et al.
PLOS COMPUTATIONAL BIOLOGY (2009)
Software news and updates - CHARNIM-GUI: A web-based grraphical user interface for CHARMM
Sunhwan Jo et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2008)
PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid - Mechanistic analysis of a familial Cowden disease-associated PTEN mutation
Yi Xiao et al.
CELLULAR SIGNALLING (2007)
Mutation screening of the PTEN gene in patients with autism spectrum disorders and macrocephaly
Joseph D. Buxbaum et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2007)
Anisotropic network model: systematic evaluation and a new web interface
Eran Eyal et al.
BIOINFORMATICS (2006)
Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations
MG Butler et al.
JOURNAL OF MEDICAL GENETICS (2005)
A hierarchical approach to all-atom protein loop prediction
MP Jacobson et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2004)
Membrane-binding and activation mechanism of PTEN
S Das et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
PTEN mutation in a family with Cowden syndrome and autism
A Goffin et al.
AMERICAN JOURNAL OF MEDICAL GENETICS (2001)
Share Paper
