Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 237, Issue 11, Pages 4112-4131Publisher
WILEY
DOI: 10.1002/jcp.30878
Keywords
diabetes; diabetes complications; mitochondrial dynamics; mitochondrial dysfunction; ncRNA
Categories
Funding
- Natural Science Foundation in Jiangxi Province [202002BAB216022, 20192ACBL21037, 202004BCJL23049]
- National Natural Science Foundation of China [82160371, 82100869]
- Youth Science Foundation of Jiangxi [20192ACBL21036]
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This review summarizes the research progress on the regulation of mitochondrial dynamics by noncoding RNAs in diabetes and its complications, which provides a promising direction for the development of antibodies or targeted drugs in the future.
Diabetes mellitus and its complications are major health concerns worldwide that should be routinely monitored for evaluating disease progression. And there is currently much evidence to suggest a critical role for mitochondria in the common pathogenesis of diabetes and its complications. Mitochondrial dynamics are involved in the development of diabetes through mediating insulin signaling and insulin resistance, and in the development of diabetes and its complications through mediating endothelial impairment and other closely related pathophysiological mechanisms of diabetic cardiomyopathy (DCM). noncoding RNAs (ncRNAs) are closely linked to mitochondrial dynamics by regulating the expression of mitochondrial dynamic-associated proteins, or by regulating key proteins in related signaling pathways. Therefore, this review summarizes the research progress on the regulation of Mitochondrial Dynamics by ncRNAs in diabetes and its complications, which is a promising area for future antibodies or targeted drug development.
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