Identification of cuproptosis-related lncRNAs for prognosis and immunotherapy in glioma

Article Cell Biology

An innovative prognostic model based on autophagy-related long noncoding RNA signature for low-grade glioma

Aierpati Maimaiti et al.

Summary: This study identified an autophagy-related lncRNA prognostic signature for low-grade glioma (LGG) patients, which plays a crucial role in prognosis and may be associated with disease progression.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2022)

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Review Biotechnology & Applied Microbiology

Copper-induced tumor cell death mechanisms and antitumor theragnostic applications of copper complexes

Yicheng Jiang et al.

Summary: Recent studies have shown that imbalanced copper homeostasis can affect tumor growth, causing irreversible damage. Copper can induce various forms of cell death, such as apoptosis and autophagy, through mechanisms involving reactive oxygen species accumulation, proteasome inhibition, and antiangiogenesis. This review highlights the antitumor mechanisms of copper, the development of biomaterials and nanotechnology incorporating copper, and the clinical applications of novel copper complexes.

NANOMEDICINE (2022)

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Article Oncology

Molecular Subtypes and Prognostic Signature of Pyroptosis-Related lncRNAs in Glioma Patients

Guilong Tanzhu et al.

Summary: The relationship between pyroptosis-related long non-coding RNAs (lncRNAs) and glioma prognosis was investigated in this study. The findings suggest that these pyroptosis-related lncRNAs can serve as independent prognostic factors and have potential value in estimating the survival of glioma patients.

FRONTIERS IN ONCOLOGY (2022)

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Article Cell Biology

Identification of Ferroptosis-Related Biomarkers for Prognosis and Immunotherapy in Patients With Glioma

Junfeng Shi et al.

Summary: This study identified nine ferroptosis-related lncRNAs and constructed a prognostic model for glioma. The model showed high sensitivity and specificity in predicting overall survival. Pathway analysis revealed the involvement of cell cycle, p53 signaling, apoptosis, and oxidative phosphorylation pathways in glioma pathogenesis. Additionally, a strong correlation between these lncRNAs and immunotherapy was observed, suggesting their potential role in guiding immune checkpoint inhibitor therapy for glioma patients.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Editorial Material Biochemistry & Molecular Biology

Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death

Paul A. Cobine et al.

Summary: Tsvetkov et al. (2022) identified a novel form of cell death caused by targeted accumulation of Cu in mitochondria, which leads to aggregation of lipoylated TCA cycle enzymes through direct Cu binding.

MOLECULAR CELL (2022)

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Article Multidisciplinary Sciences

Copper induces cell death by targeting lipoylated TCA cycle proteins

Peter Tsvetkov et al.

Summary: Copper is an essential cofactor for all organisms, but excessive copper can lead to cell death. We found that copper-dependent cell death mechanism is different from known mechanisms, and it is related to mitochondrial respiration. Copper directly binds to lipoylated components of the tricarboxylic acid cycle, causing protein aggregation and loss of iron-sulfur cluster proteins, ultimately leading to cell death.

SCIENCE (2022)

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Article Biotechnology & Applied Microbiology

Mitochondrial copper depletion suppresses triple-negative breast cancer in mice

Liyang Cui et al.

Summary: The research developed a mitochondria-targeted copper-depleting nanoparticle that effectively inhibited the growth of triple-negative breast cancer cells and improved survival rates in mouse models. By depriving copper within cancer cells, this approach induced metabolic changes and apoptosis, highlighting its potential clinical relevance.

NATURE BIOTECHNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Ferroptosis-related gene signature correlates with the tumor immune features and predicts the prognosis of glioma patients

Yan Hu et al.

Summary: The study established a ferroptosis-related signature (FRSig) to evaluate the prognosis of glioma patients and its role in the microenvironment. By stratifying patient groups and utilizing methods like single-sample gene set enrichment analysis (ssGSEA), a diagnostic model related to clinical outcomes was developed.

BIOSCIENCE REPORTS (2021)

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Article Oncology

A novel pyroptosis-related gene signature predicts the prognosis of glioma through immune infiltration

Moxuan Zhang et al.

Summary: This study established a risk model based on pyroptosis-related genes for predicting the survival risk of glioma patients. The risk score was found to be an independent factor predicting overall survival and was verified in a validation cohort. Analysis showed that high-risk glioma patients had significantly upregulated immune cell and pathway activities compared to low-risk patients.

BMC CANCER (2021)

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Article Multidisciplinary Sciences

Copper depletion modulates mitochondrial oxidative phosphorylation to impair triple negative breast cancer metastasis

Divya Ramchandani et al.

Summary: Copper chelation reduces TNBC metastasis by inactivating Complex IV in sensitive SOX2/OCT4+ cells, showing potential to enrich patient populations in next-generation therapeutic trials.

NATURE COMMUNICATIONS (2021)

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Article Genetics & Heredity

Chinese Glioma Genome Atlas (CGGA) : A Comprehensive Resource with Functional Genomic Data from Chinese Glioma Patients

Zheng Zhao et al.

Summary: The Chinese Glioma Genome Atlas (CGGA) is a user-friendly data portal for the storage and interactive exploration of cross-omics data related to gliomas. It provides researchers with rapid and convenient access to high-quality functional genomic data resources for biological studies and clinical applications.

GENOMICS PROTEOMICS & BIOINFORMATICS (2021)

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Article Oncology

High tumor mutation burden fails to predict immune checkpoint blockade response across all cancer types

D. J. McGrail et al.

Summary: Analysis of over 10,000 patient tumors from The Cancer Genome Atlas showed that TMB-H tumors had significantly higher response rates to immune checkpoint blockade in certain cancer types, while showing no significant benefit in others. These results do not support the use of TMB-H as a biomarker for ICB treatment across all solid cancer types, indicating the need for further tumor type-specific studies.

ANNALS OF ONCOLOGY (2021)

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Review Oncology

FDA-Approved and Emerging Next Generation Predictive Biomarkers for Immune Checkpoint Inhibitors in Cancer Patients

Ye Wang et al.

Summary: The response to immune checkpoint inhibitors is a complex quantitative trait determined by multiple factors, for which FDA-approved biomarkers are used for patient selection. However, challenges in daily practice and the different factors captured by the biomarkers highlight the need for optimized use of current biomarkers and development of new predictive biomarkers. Various gene signature biomarkers and combined predictive biomarkers have shown improved performance compared to single predictors, suggesting a potential direction for robust predictive biomarker development for ICI response.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

Development and Validation of an Immune-Related Long Non-coding RNA Prognostic Model in Glioma

Xiaowei Qiu et al.

Summary: By analyzing immune-related lncRNAs in glioma patients, a clinical model with potential prognostic value was successfully constructed, providing insights into the immunological mechanisms of glioma and guiding future treatment strategies.

JOURNAL OF CANCER (2021)

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Article Oncology

IDH-wildtype lower-grade diffuse gliomas: the importance of histological grade and molecular assessment for prognostic stratification

Giulia Berzero et al.

Summary: The study finds that IDHwt grade II gliomas have a relatively higher survival rate, while patients meeting the definition of molecular glioblastoma have a shorter survival period. The majority of patients meeting the cIMPACT criteria have isolated TERT promoter mutations, which are not significantly associated with poor outcomes.

NEURO-ONCOLOGY (2021)

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Review Oncology