Journal
JOURNAL OF CELL BIOLOGY
Volume 221, Issue 10, Pages -Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.202205135
Keywords
-
Categories
Funding
- Norwegian Cancer Society [198140, 182698]
- South-Eastern Norway Regional Health Authority [2018081]
- European Research Council [788954]
- Radium Hospital Foundation
- Research Council of Norway through its Centres of Excellence funding scheme [262652]
- European Research Council (ERC) [788954] Funding Source: European Research Council (ERC)
Ask authors/readers for more resources
The endoplasmic reticulum regulates the positioning, dynamics, and functions of other organelles through membrane contact sites. It controls organelles such as endosomes, lysosomes, autophagosomes, mitochondria, peroxisomes, and the Golgi apparatus through lipid and Ca2+ transfer, phosphorylation reactions, and control of organelle motility, fusion, and fission.
Wenzel et al. review how the endoplasmic reticulum controls the positioning, dynamics, and functions of other organelles via membrane contact sites. The endoplasmic reticulum (ER), which occupies a large portion of the cytoplasm, is the cell's main site for the biosynthesis of lipids and carbohydrate conjugates, and it is essential for folding, assembly, and biosynthetic transport of secreted proteins and integral membrane proteins. The discovery of abundant membrane contact sites (MCSs) between the ER and other membrane compartments has revealed that, in addition to its biosynthetic and secretory functions, the ER plays key roles in the regulation of organelle dynamics and functions. In this review, we will discuss how the ER regulates endosomes, lysosomes, autophagosomes, mitochondria, peroxisomes, and the Golgi apparatus via MCSs. Such regulation occurs via lipid and Ca2+ transfer and also via control of in trans dephosphorylation reactions and organelle motility, positioning, fusion, and fission. The diverse controls of other organelles via MCSs manifest the ER as master regulator of organelle biology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available