Palladium-catalyzed domino carbonylative cyclization to access functionalized heterocycles

A novel palladium-catalyzed domino carbonylative cyclization of alkene-tethered indole derivatives with alkyne-tethered nucleophiles has been developed, which provides a straightforward and efficient plat-form for the rapid construction of functionalized heterocycles. By using benzene-1,3,5-triyl triformate (TFBen) as the CO source, this domino reaction proceeded smoothly with the consecutive formation of three C-C bonds and one C-X bond to furnish a variety of biologically relevant indolo[2,1-a] isoquinoline-indole and indolo[2,1-a]isoquinoline-dihydrobenzofuran derivatives in good yields.(c) 2022 Elsevier Inc. All rights reserved.

Automated summary

A novel palladium-catalyzed domino carbonylative cyclization has been developed for the rapid construction of functionalized heterocycles. The reaction proceeds smoothly with the consecutive formation of C-C and C-X bonds using benzene-1,3,5-triyl triformate as the CO source, yielding a variety of biologically relevant derivatives.