Journal
JOURNAL OF INNATE IMMUNITY
Volume 8, Issue 6, Pages 531-540Publisher
KARGER
DOI: 10.1159/000446840
Keywords
Cystic fibrosis; Lung disease; Host defense; Immune response; Neutrophils; Pattern recognition receptors; Toll-like receptor
Categories
Funding
- German Research Foundation (DFG at Tubingen ) [SFB/CRC685]
- European Respiratory Society (ERS RESPIRE 2 fellowship)
Ask authors/readers for more resources
Cystic fibrosis (CF) lung disease is characterized by chronic infection and inflammation. The inflammatory response in CF is dominated by the activation of the innate immune system. Bacteria and fungi represent the key pathogens chronically colonizing the CF airways. In response, innate immune pattern recognition receptors, expressed by airway epithelial and myeloid cells, sense the microbial threat and release chemoattractants to recruit large numbers of neutrophils into CF airways. However, neutrophils fail to efficiently clear the invading pathogens, but instead release harmful proteases and oxidants and finally cause tissue injury. Here, we summarize and discuss current concepts and controversies in the field of innate immunity in CF lung disease, facing the ongoing questions of whether inflammation is good or bad in CF and how innate immune mechanisms could be harnessed therapeutically. (C) 2016 S. Karger AG, Basel
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available