Journal
JOURNAL OF CARDIOLOGY
Volume 81, Issue 2, Pages 189-195Publisher
ELSEVIER
DOI: 10.1016/j.jjcc.2022.09.001
Keywords
Radial access; Femoral access; ST -elevation myocardial infarction; Bleeding; Door to device time
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The study analyzed data from a Japanese registry to compare the outcomes of patients with ST-elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI) with radial access and femoral access. The results showed that radial access was associated with lower rates of major adverse cardiac event (MACE), bleeding events, and composite events.
Background: The access site for primary percutaneous coronary intervention (PCI) for patients with ST-elevation myocardial infarction (STEMI) recently shifted from femoral to radial. However, few real-world data on Japanese patients exist.Methods: To elucidate the clinical selection and impact of the access site in STEMI patients, we analyzed a Japanese observational prospective multicenter registry of acute myocardial infarction (K-ACTIVE: Kanagawa ACuTe cardIoVascular rEgistry) in 2015 to 2021. Data were analyzed in the entire population and a propensity score-matched population adjusted for confounding factors. Major adverse cardiac event (MACE) was defined as cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke. Bleeding Academic Research Consortium (BARC) type 3 or 5 was used to assess bleeding events. MACE plus BARC type 3 or 5 bleeding were considered composite events. Clinical outcomes were followed for 30 days.Results: The 6802 STEMI patients included 4786 patients with radial access (70.3 %) and 2016 with femoral access (29.7 %). Femoral access tended to be selected for more severe conditions than radial access. The median door-to -device time in the radial access group was significantly shorter than the femoral access group in the entire pop-ulation (75 min versus 79 min, p < 0.01). After propensity score matching (each group, n =1208), the incidence of MACE tended to be lower in the radial access group [risk ratio (RR) 0.83, 95 % confidence interval (CI) 0.63- 1.09, p = 0.17]. The incidence of BARC 3 or 5 bleeding was significantly less in the radial access group (RR 0.47, 95%CI 0.23-0.97, p = 0.04). The incidence of composite events was significantly less in the radial access group (RR 0.74, 95%CI 0.57-0.96, p = 0.02).Conclusion: In STEMI patients undergoing primary PCI, in comparison to femoral access, radial access reduced composite events in the entire population and the matched population, through a reduction in MACE and BARC 3 or 5 bleeding.(c) 2022 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
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