Journal
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
Volume 149, Issue 1, Pages 401-421Publisher
SPRINGER
DOI: 10.1007/s00432-022-04398-z
Keywords
Retinoblastoma; Long non-coding RNA; Biomarker; Oncogene; Tumor suppressor
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Retinoblastoma (RB) is the most common childhood tumor that requires novel treatment strategies. Molecular-based targeted therapies have opened up new possibilities for RB, and long non-coding RNAs (lncRNAs) may serve as biomarkers for early detection of RB.
Introduction Retinoblastoma (RB) is the most common childhood tumor that can occur in the retina and develop in a sporadic or heritable form. Although various traditional treatment options have been used for patients with RB, identifying novel strategies for childhood cancers is necessary. Material and methods Recently, molecular-based targeted therapies have opened a greater therapeutic window for RB. Long non-coding RNAs (lncRNAs) presented a potential role as a biomarker for the detection of RB in various stages. Conclusion LncRNAs by targeting several miRNA/transcription factors play critical roles in the stimulation or suppression of RB. In this review, we summarized recent progress on the functions of tumor suppressors or oncogenes lncRNAs in RB.
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