Journal
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
Volume 41, Issue 17, Pages 8485-8505Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07391102.2022.2135593
Keywords
Sesame oil; valproic acid; xenobiotics; inflammation; oxidative stress; molecular docking
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This study found that sesame oil has a protective effect against valproic acid-induced hepatotoxicity. It attenuates oxidative stress and inflammation caused by valproic acid. Molecular docking analysis revealed the underlying mechanism of its protective effect.
Sesame oil (SO) has been exhibited to have anti-inflammatory and antioxidant influences. The goal of this experiment was to look into SO's hepato-protective properties and underlying processes in valproic acid (VPA)-induced hepatotoxicity. Molecular docking was carried out to clarify the functional and structural underlying mechanism of SO ameliorative effect. Mice were given 8 mL/kg/day of SO (orally) and 100 mg/kg/day of VPA (i.p.) for 21 days. The results revealed that VPA caused a considerable increase in hepatic malondialdehyde levels while decreasing the activity of glutathione peroxidase (GPx) enzyme. There was also a significant rise in serum levels of interleukins 1 beta and 6 (IL-1 beta and IL-6) and a significant decrease in hepatic (PXR) gene expression level. SO co-administration with VPA significantly normalized the antioxidant and anti-inflammatory status and upregulated the gene expression level of PXR. In silico docking analysis results confirmed these results. This study concluded that supplementation of SO attenuated VPA-induced oxidative stress and inflammation. Hence, it was recommended as a dietary supplement for protection against VPA-induced hepatotoxicity. Communicated by Ramaswamy H. Sarma
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