Journal
JOURNAL OF INFRARED MILLIMETER AND TERAHERTZ WAVES
Volume 37, Issue 8, Pages 805-814Publisher
SPRINGER
DOI: 10.1007/s10762-016-0271-z
Keywords
Sub-terahertz wave; Gyrotron; Hyperthermia; Photodynamic therapy; Cancer treatment
Funding
- Foundation JST
- Foundation JSPS
- Top Analysis Technology and Development of the Instrument Project
- JSPS [26640090, 11557116, 17029024, 14370793, 11672293]
- JST-Innovation
- Cosmo Oil Ltd. Co.
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) in Japan
- Grants-in-Aid for Scientific Research [11557116, 14370793, 11672293, 17029024, 26640090] Funding Source: KAKEN
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In this paper, we present results of a hyperthermia treatment of malignant tumors using a gyrotron as a radiation source for heating of the cancerous tissue. They clearly demonstrate the efficiency of the irradiation by sub-THz waves, which leads to steady decrease of the volume of the tumor and finally to its disappearance. A combination of hyperthermia and photodynamic therapy (PDT) that utilizes a novel multifunctional photosensitizer has also been explored. In the latter case, the results are even more convincing and promising. In particular, while after a hyperthermia treatment sometimes a regrowth of the tumor is being observed, in the case of combined hyperthermia and PDT such regrowth has never been noticed. Another combined therapy is based on a preheating of the tumor by gyrotron radiation to temperatures lower than the hyperthermia temperature of 43 A degrees C and followed then by PDT. The results show that such combination significantly increases the efficiency of the treatment. We consider this phenomenon as a synergy effect since it is absent when hyperthermia and PDT are applied separately, and manifests itself only when both methods are combined.
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