Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 25, Issue 6, Pages 603-609Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2022.2113975
Keywords
Tinospora sinensis; Menispermaceae; phenylpropanoid glycoside; tinosinen A; nitric oxide inhibitory
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One new phenylpropanoid glycoside and 13 known compounds were isolated from Tinospora sinensis (Lour.) Merr. The phenylpropanoid glycoside showed significant inhibitory activity against NO production in macrophages. Several other compounds also exhibited moderate NO inhibitory activity.
One new phenylpropanoid glycoside, tinosinen A (1) and 13 known compounds, tinosinen (2), citrusin B (3), picraquassioside C (4), erythro-guaiacylglycerol-beta-O-4 '-coniferyl alcohol (5), erythro-guaiacylglycerol-8-O-4 '-(sinapyl alcohol) ether (6), erythro-syringylglycerol-8-O-4 '-(sinapyl alcohol) ether (7), seco-isolariciresinol 9-O-D-beta-glucopyranoside (8), tinosposide A (9), pinoresinol-4 '-O-beta-D-glucopyranoside (10), syringaresinol-4 '-O-beta-D-glucopyranoside (11), pinoresinol (12), syringaresinol (13), and lirioresino-beta-dimethyl ether (14) were isolated from the stems of Tinospora sinensis (Lour.) Merr. Their structures were established by detailed spectroscopic studies and comparisons with those reported in the literature. Compound 13 showed significant inhibitory NO production (IC50 value of 38.53 +/- 1.90 mu M) in RAW264.7 macrophages, LPS-stimulated. Compounds 3-7, 11, 12, and 14 inhibited NO production with IC50 values ranging from 38.53 to 99.07 mu M.
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