Journal
JOURNAL OF APPLIED PHYSICS
Volume 132, Issue 17, Pages -Publisher
AIP Publishing
DOI: 10.1063/5.0119787
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Funding
- National Key Research and Development Program of China [2019YFC1521102]
- National Natural Science Foundation of China [61701403, 61806164, 62101439, 61906154]
- China Postdoctoral Science Foundation [2018M643719]
- Natural Science Foundation of Shaanxi Province [2020JQ-601]
- Young Talent Support Program of the Shaanxi Association for Science and Technology [20190107]
- Key Research and Development Program of Shaanxi Province [2019GY-215, 2021ZDLSF06-04]
- Major research and development project of Qinghai [2020-SF-143]
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Cerenkov luminescence tomography (CLT) is a non-invasive technique for three-dimensional detection of radiopharmaceuticals. The proposed multi-stage cascade neural network improves the performance of CLT reconstruction by introducing an attention mechanism and a special constraint. Numerical simulations and in vivo experiments demonstrate that this method achieves superior accuracy and shape recovery capability compared to existing methods.
Cerenkov luminescence tomography (CLT) is a highly sensitive and promising technique for three-dimensional non-invasive detection of radiopharmaceuticals in living organisms. However, the severe photon scattering effect causes ill-posedness of the inverse problem, and the results of CLT reconstruction are still unsatisfactory. In this work, a multi-stage cascade neural network is proposed to improve the performance of CLT reconstruction, which is based on the attention mechanism and introduces a special constraint. The network cascades an inverse sub-network (ISN) and a forward sub-network (FSN), where the ISN extrapolates the distribution of internal Cerenkov sources from the surface photon intensity, and the FSN is used to derive the surface photon intensity from the reconstructed Cerenkov source, similar to the transmission process of photons in living organisms. In addition, the FSN further optimizes the reconstruction results of the ISN. To evaluate the performance of our proposed method, numerical simulation experiments and in vivo experiments were carried out. The results show that compared with the existing methods, this method can achieve superior performance in terms of location accuracy and shape recovery capability.
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