Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 214, Issue 3, Pages 399-402Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiw165
Keywords
HIV-1 drug resistance; integrase; transmission of drug resistance; prevalence; population viral load
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Funding
- Swiss National Science Foundation [33CS30_148522, 320030_159868, PZ00P3-142411]
- SHCS [470, 528, 569, 683]
- SHCS Research Foundation
- Yvonne-Jacob Foundation
- Gilead, Switzerland
- University of Zurich
- Swiss National Science Foundation (SNF) [33CS30_148522] Funding Source: Swiss National Science Foundation (SNF)
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The prevalence of integrase strand transfer inhibitor (INSTI)-transmitted drug resistance (TDR) may increase with the increasing use of INSTIs. We analyzed the prevalence of INSTI TDR in the Swiss HIV Cohort Study (2008-2014). In 1 of 1316 drug-naive samples (0.1%), a major INSTI TDR mutation was detected. Prevalence was stable, although INSTIs were increasingly used. We showed that this is in contrast to the introduction of previous drug classes, in which more treatment failures with resistant strains occurred and TDR was observed more rapidly. We demonstrated on a population-level that it is possible to avoid TDR to a new drug class for years.
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