Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 214, Issue 9, Pages 1399-1402Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiw398
Keywords
fatal varicella; nosocomial transmission; whole genome sequencing
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Funding
- MRC Centre for Medical Molecular Virology
- Medical Research Foundation
- National Institute for Health Research
- NIHR Biomedical Resource Centre at University College London Hospitals NHS Foundation Trust and University College London
- MRC [G0700814] Funding Source: UKRI
- Medical Research Foundation [C0485] Funding Source: researchfish
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We report the first use of whole viral genome sequencing to identify nosocomial transmission of varicella-zoster virus with fatal outcome. The index case patient, nursed in source isolation, developed disseminated zoster with rash present for 1 day before being transferred to the intensive care unit (ICU). Two patients who had received renal transplants while inpatients in an adjacent ward developed chickenpox and 1 died; neither patient had direct contact with the index patient.
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