☆ 4.7 Article

Total Sesquiterpenoids of Loquat Leaves Alleviated High-Fat Diet-Induced Obesity by Targeting Fecal Metabolic Profiling and Gut Microbiota Composition

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

Related references

Note: Only part of the references are listed.

Review Genetics & Heredity

Gut microbiota in patients with obesity and metabolic disorders - a systematic review

Zhilu Xu et al.

Summary: This study identified specific bacteria associated with obesity and metabolic disorders in both western and eastern populations. Mechanistic studies are required to determine whether these microbes are a cause or a product of obesity and metabolic disorders.

GENES AND NUTRITION (2022)

Add to Collection

Article Biochemical Research Methods

Black raspberry extract shifted gut microbe diversity and their metabolic landscape in a human colonic model

Shiqi Zhang et al.

Summary: This study investigated the impact of black raspberry extract on the gut microbiota composition and metabolism using an in vitro human colonic model. The results showed that black raspberry intervention could modulate the composition and metabolism of gut microbiota, potentially affecting host metabolism and health.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Sesquiterpene glycoside isolated from loquat leaf targets gut microbiota to prevent type 2 diabetes mellitus in db/db mice

Ruoyun Wu et al.

Summary: Loquat leaf contains sesquiterpene glycosides that can prevent type 2 diabetes by relieving insulin resistance and inflammation, as well as reshaping the gut microbiota.

FOOD & FUNCTION (2022)

Add to Collection

Review Medicine, Research & Experimental

The links between gut microbiota and obesity and obesity related diseases

Jiafeng Geng et al.

Summary: The obesity epidemic has become a global public health crisis, with the pathophysiological mechanisms still being unraveled. Gut microbiota plays a crucial role in obesity and related diseases, influencing obesity progression through changes in composition and metabolites, with potential therapeutic implications in targeting relevant metabolic pathways.

BIOMEDICINE & PHARMACOTHERAPY (2022)

Add to Collection

Article Neurosciences

Cognitive Function Associated with Gut Microbial Abundance in Sucrose and S-Adenosyl-L-Methionine (SAMe) Metabolic Pathways

Sohyun Jeong et al.

Summary: This study analyzed the gut microbiota of AD patients and found that there were similar levels of gut microbe community diversity between dementia and MCI. However, differential analyses at lower-level taxa and metabolic pathways revealed differences, suggesting that specific gut microbes in the Firmicutes and Actinobacteria phyla might be involved in cognitive decline.

JOURNAL OF ALZHEIMERS DISEASE (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Tangeretin prevents obesity by modulating systemic inflammation, fat browning, and gut microbiota in high-fat diet-induced obese C57BL/6 mice

Qiyang Chen et al.

Summary: Tangeretin supplementation has a preventative effect on obesity and associated comorbidities by improving adipose thermogenesis, reducing systemic inflammation, and reversing gut microbiota dysbiosis.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2022)

Add to Collection

Article Food Science & Technology

Portulaca oleracea L. Extract Alleviated Type 2 Diabetes Via Modulating the Gut Microbiota and Serum Branched-Chain Amino Acid Metabolism

Meili Bao et al.

Summary: Portulaca oleracea L. extracts (PE) improve diabetes-related biochemical abnormalities by modulating gut microbiota composition and branched-chain amino acids (BCAAs) metabolism, as well as protecting intestinal mucosal epithelium.

MOLECULAR NUTRITION & FOOD RESEARCH (2022)

Add to Collection

Article Microbiology

Alleviation of Hepatic Steatosis: Dithizone-Related Gut Microbiome Restoration During Paneth Cell Dysfunction

Saisai Zhang et al.

Summary: This study found that pharmacologically depleting Paneth cells and modulating gut microbiome composition can alleviate the severity of non-alcoholic fatty liver disease (NAFLD) in high-fat diet mice. Increase in Bacteroides in the gut microbiome may play an important role in this process.

FRONTIERS IN MICROBIOLOGY (2022)

Add to Collection

Review Pediatrics

Non-alcoholic fatty liver disease and childhood obesity

Meera Shaunak et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) in children and adolescents is estimated to have a prevalence of 36.1% in the context of obesity, and is expected to increase with the global obesity epidemic. Early detection and treatment of NAFLD in childhood is crucial, with healthy eating and physical activity being the primary prevention and treatment strategies currently available.

ARCHIVES OF DISEASE IN CHILDHOOD (2021)

Add to Collection

Review Microbiology

Gut microbiota in human metabolic health and disease

Yong Fan et al.

Summary: The intestinal microbiota plays a significant role in human metabolic health, potentially contributing to the development of common metabolic disorders when dysregulated. Current research is shifting towards cause-and-effect studies and utilizing high-throughput human multi-omics data to identify potential molecular mechanisms behind these associations.

NATURE REVIEWS MICROBIOLOGY (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Occurrence of Morpholine in Central Nervous System Drug Discovery

Elena Lenci et al.

Summary: Morpholine and its analogues are valuable heterocycles in developing drugs for the central nervous system (CNS), due to their conformational and physicochemical properties that improve permeability through the blood-brain barrier and enhance blood solubility of the overall structure. They are utilized to enhance potency through molecular interactions, direct appendages in the correct position, and modulate pharmacokinetic/pharmacodynamic properties in CNS-active compounds. Additionally, morpholine derivatives play a crucial role in interacting with active sites of different targets, particularly in mood disorders, pain, neurodegenerative diseases, and CNS tumors.

ACS CHEMICAL NEUROSCIENCE (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Effects of Gut Metabolites and Microbiota in Healthy and Marginal Livers Submitted to Surgery

Marc Mico-Carnero et al.

Summary: Microbiota in the gut plays a crucial role in the development of liver diseases and post-operative outcomes. Imbalance in the microbiota can lead to liver diseases. Changes in the microbiota after surgery have significant effects on post-operative outcomes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Agriculture, Multidisciplinary

Novel Sesquiterpene Glycoside from Loquat Leaf Alleviates Type 2 Diabetes Mellitus Combined with Nonalcoholic Fatty Liver Disease by Improving Insulin Resistance, Oxidative Stress, Inflammation, and Gut Microbiota Composition

Jian Chen et al.

Summary: SG3, a novel sesquiterpene glycoside isolated from loquat leaf, has shown preventive effects against T2DM-associated NAFLD by improving insulin resistance, oxidative stress, and inflammation through regulating insulin signaling and inhibiting CYP2E1/NLRP3 pathways. Additionally, SG3 treatment can modulate the gut microbiome composition in db/db mice.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

Add to Collection

Article Cell Biology

Adipose-Derived Stem Cells from Obese Donors Polarize Macrophages and Microglia toward a Pro-Inflammatory Phenotype

Mark A. A. Harrison et al.

Summary: ASCs from obese donors exhibit reduced stem cell characteristics and promote a pro-inflammatory phenotype in macrophage and microglial cells. This highlights the importance of considering individual donor characteristics such as obesity when selecting donors and cells for use in ASC therapeutic applications and regenerative medicine.

CELLS (2021)

Add to Collection

Article Medicine, Research & Experimental

Bupleuri radix extract ameliorates impaired lipid metabolism in high-fat diet-induced obese mice via gut microbia-mediated regulation of FGF21 signaling pathway

Liucen Wu et al.

Summary: The study confirmed the regulatory effect of Bupleuri Radix on lipid metabolism in obese mice and its anti-obesity mechanism through the gut-liver axis, identifying two intestinal microorganisms playing essential roles in this axis.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Add to Collection

Article Cell Biology

Total Sesquiterpene Glycosides from Loquat Leaves Ameliorate HFD-Induced Insulin Resistance by Modulating IRS-1/GLUT4, TRPV1, and SIRT6/Nrf2 Signaling Pathways

Ruoyun Wu et al.

Summary: This study demonstrated that total sesquiterpene glycosides (TSGs) from loquat leaves improved metabolic parameters and prevented liver injury in insulin-resistant (IR) mice induced by high-fat diet. TSG supplementation also alleviated inflammatory response and oxidative stress in IR mice, and modulated signaling pathways related to glucose and lipid metabolism in the liver.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Add to Collection

Article Multidisciplinary Sciences

Short-term high-fat feeding exacerbates degeneration in retinitis pigmentosa by promoting retinal oxidative stress and inflammation

Oksana Kutsyr et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Add to Collection

Article Immunology

Dysbiosis of the Saliva Microbiome in Patients With Polycystic Ovary Syndrome

Na Li et al.

Summary: Significant differences in salivary microbiota were observed between PCOS patients and healthy controls, with PCOS disrupting the diurnal rhythm of salivary microbiota abundance. No similar changes were found in the oral and fecal microbiota of PCOS patients and controls, indicating a unique disruption in the oral microbiota of PCOS patients.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences

Synbiotic (Lactiplantibacillus pentosus GSSK2 and isomalto-oligosaccharides) supplementation modulates pathophysiology and gut dysbiosis in experimental metabolic syndrome

Sakshi Khanna et al.

Summary: The study demonstrates the protective potential of a synbiotic in attenuating metabolic complications induced by a high fat diet, improving various morphometric parameters and influencing gut microbiota and metabolic markers positively.

SCIENTIFIC REPORTS (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Effect of Methionine Restriction on Aging: Its Relationship to Oxidative Stress

Munehiro Kitada et al.

Summary: Methionine restriction (MetR) impacts lifespan extension and metabolic health by reducing oxidative stress through various mechanisms, such as activating autophagy, increasing hydrogen sulfide and polyamine production, and inhibiting mitochondrial reactive oxygen species generation.

BIOMEDICINES (2021)

Add to Collection

Article Plant Sciences

A draft genome, resequencing, and metabolomes reveal the genetic background and molecular basis of the nutritional and medicinal properties of loquat (Eriobotrya japonica (Thunb.) Lindl)

Yunsheng Wang

Summary: This study reported the genome information of the loquat 'Big Five-pointed Star' cultivar, as well as the research on its flesh color, metabolites, and genes related to the biosynthesis of medicinal ingredients, revealing a potential association between expanding gene families and high concentrations of beneficial metabolites in the loquat plant.

HORTICULTURE RESEARCH (2021)

Add to Collection

Article Ecology

Distinct composition and metabolic functions of human gut microbiota are associated with cachexia in lung cancer patients

Yueqiong Ni et al.

Summary: Our study revealed significant differences in gut microbial composition, functional pathways, and plasma metabolites between cachexia and non-cachectic patients, suggesting a potential influence of the gut microbiota on cachexia in a clinical setting.

ISME JOURNAL (2021)

Add to Collection

Article Microbiology

Effects of S24-7 on the weight of progeny rats after exposure to ceftriaxone sodium during pregnancy

Xin Yang et al.

Summary: Exposure to ceftriaxone sodium during pregnancy has a long-lasting adverse effect on offspring growth, possibly through an imbalance of gut microbiota, especially with regard to the dominant bacteria S24-7, affecting different metabolic pathways.

BMC MICROBIOLOGY (2021)

Add to Collection

Article Endocrinology & Metabolism

Microecological preparation combined with an modified low-carbon diet improves glucolipid metabolism and cardiovascular complication in obese patients

Jianguo Liu et al.

Summary: The study found that the combination of microecological preparation with modified low-carbon diet significantly improved glucolipid metabolism and cardiovascular complications in obese patients, but further research is needed on the effect on carotid atherosclerotic plaque.

DIABETOLOGY & METABOLIC SYNDROME (2021)

Add to Collection

Review Nutrition & Dietetics

Do Gut Microbes Taste?

Ryan Leung et al.

Summary: This article reviews the role of gut bacteria in taste perception and functions, and discusses how intestinal dysbiosis can alter taste preference and food consumption.

NUTRIENTS (2021)

Add to Collection

Review Gastroenterology & Hepatology

Gut microbiota: a target for intervention in obesity

Kanika Sehgal et al.

Summary: Obesity is a major public health concern, with studies suggesting a link between gut microbiota and obesity. Microbiota restoration therapies are being considered as a potential management approach, but more research is needed to determine the efficacy and safety. Personalized therapies for obese individuals may become possible once the relationships between bacterial strains and human metabolic profiles are better understood.

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY (2021)

Add to Collection

Article Endocrinology & Metabolism

Epidemiology and determinants of obesity in China

Xiong-Fei Pan et al.

Lancet Diabetes & Endocrinology (2021)

Add to Collection

Review Endocrinology & Metabolism

Obesity: Epidemiology, Pathophysiology, and Therapeutics

Xihua Lin et al.

Summary: Obesity is a complex multifactorial disease with negative health effects, mainly caused by an energy imbalance. Treatment strategies should focus on biological mechanisms and reducing BMI.

FRONTIERS IN ENDOCRINOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Antibiotic-Induced Dysbiosis of Microbiota Promotes Chicken Lipogenesis by Altering Metabolomics in the Cecum

Tao Zhang et al.

Summary: This study revealed that oral antibiotics significantly promoted lipogenesis in chickens by inducing dysbiosis of gut microbiota. Metabolomics analysis showed alterations in abundance of various metabolites, highlighting the intricate relationship between microbiota and fat synthesis.

METABOLITES (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Polysaccharide from Flammulina velutipes attenuates markers of metabolic syndrome by modulating the gut microbiota and lipid metabolism in high fat diet-fed mice

Ruiqiu Zhao et al.

Summary: This study demonstrated that dietary supplementation of FVP and FMT could attenuate obesity, hyperlipidemia, and insulin resistance in mice fed with a high-fat diet. These effects may be mediated through different mechanisms involving lipid metabolism and regulation of gut microbiota.

FOOD & FUNCTION (2021)

Add to Collection

Article Biochemistry & Molecular Biology

A flavonoid-rich Smilax china L. extract prevents obesity by upregulating the adiponectin-receptor/AMPK signalling pathway and modulating the gut microbiota in mice

Xin Li et al.

Summary: The study found that Smilax china L. flavonoid (SCF) can help slow down obesity and lipid metabolism disorders, potentially through enhancing the adiponectin receptor/AMPK signaling pathway and improving gut microbiota composition.

FOOD & FUNCTION (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems

Obesity Phenotypes, Diabetes, and Cardiovascular Diseases

Marie-Eve Piche et al.

CIRCULATION RESEARCH (2020)

Add to Collection

Review Nutrition & Dietetics

You Are What You Eat-The Relationship between Diet, Microbiota, and Metabolic Disorders-A Review

Malgorzata Moszak et al.

NUTRIENTS (2020)

Add to Collection

Article Microbiology

Administration of Exogenous Melatonin Improves the Diurnal Rhythms of the Gut Microbiota in Mice Fed a High-Fat Diet

Jie Yin et al.

MSYSTEMS (2020)

Add to Collection

Article Food Science & Technology

Methionine Restriction Regulates Cognitive Function in High-Fat Diet-Fed Mice: Roles of Diurnal Rhythms of SCFAs Producing- and Inflammation-Related Microbes

Luanfeng Wang et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2020)

Add to Collection

Article Endocrinology & Metabolism

Protein, amino acids and obesity treatment

Mathilde Simonson et al.

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS (2020)

Add to Collection

Article Medicine, Research & Experimental

Parthenolide ameliorates colon inflammation through regulating Treg/Th17 balance in a gut microbiota-dependent manner

Yao-Jiang Liu et al.

THERANOSTICS (2020)

Add to Collection

Article Endocrinology & Metabolism

The epidemiology of obesity

Yu Chung Chooi et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2019)

Add to Collection

Article Agriculture, Multidisciplinary

A metagenomic analysis of the modulatory effect of Cyclocarya paliurus flavonoids on the intestinal microbiome in a high-fat diet-induced obesity mouse model

Lu Cheng et al.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2019)

Add to Collection

Article Nutrition & Dietetics

Dietary Nutrients Involved in One-Carbon Metabolism and Colonic Mucosa-Associated Gut Microbiome in Individuals with an Endoscopically Normal Colon

Shawn Gurwara et al.

NUTRIENTS (2019)

Add to Collection

Article Microbiology

Alterations in Gut Glutamate Metabolism Associated with Changes in Gut Microbiota Composition in Children with Autism Spectrum Disorder

Mingbang Wang et al.

MSYSTEMS (2019)

Add to Collection

Article Chemistry, Medicinal

Metabolomics Associated with Genome-Wide Association Study Related to the Basal Metabolic Rate in Overweight/Obese Korean Women

Min Jung Kim et al.

JOURNAL OF MEDICINAL FOOD (2019)

Add to Collection

Review Nutrition & Dietetics

Nutraceutical Potential of Carica papaya in Metabolic Syndrome

Lidiani F. Santana et al.

NUTRIENTS (2019)

Add to Collection

Article Endocrinology & Metabolism

Understanding the Role of the Gut Microbiome and Microbial Metabolites in Obesity and Obesity-Associated Metabolic Disorders: Current Evidence and Perspectives

Natalia Vallianou et al.

CURRENT OBESITY REPORTS (2019)

Add to Collection

Review Nutrition & Dietetics

Gut Microbiota and Obesity: A Role for Probiotics

Ludovico Abenavoli et al.

NUTRIENTS (2019)

Add to Collection

Article Food Science & Technology

Dietary compounds and traditional Chinese medicine ameliorate type 2 diabetes by modulating gut microbiota

Qixing Nie et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2019)

Add to Collection

Review Endocrinology & Metabolism

Gut microbiota and obesity: An opportunity to alter obesity through faecal microbiota transplant (FMT)

Patrick Lee et al.

DIABETES OBESITY & METABOLISM (2019)

Add to Collection

Article Nutrition & Dietetics

Importance of gut microbiota in obesity

Isabel Cornejo-Pareja et al.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2019)

Add to Collection

Review Endocrinology & Metabolism

Gut microbial metabolites in obesity, NAFLD and T2DM

Emanuel E. Canfora et al.

NATURE REVIEWS ENDOCRINOLOGY (2019)

Add to Collection

Article Pharmacology & Pharmacy

Phloretin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice by regulating the gut microbiota

Minna Wu et al.

PHARMACOLOGICAL RESEARCH (2019)

Add to Collection

Article Nutrition & Dietetics

Diet, Gut Microbiota, and Obesity: Links with Host Genetics and Epigenetics and Potential Applications

Amanda Cuevas-Sierra et al.

ADVANCES IN NUTRITION (2019)

Add to Collection

Article Medicine, General & Internal

Guideline Recommendations for Obesity Management

Donna H. Ryan et al.

MEDICAL CLINICS OF NORTH AMERICA (2018)

Add to Collection

Article Food Science & Technology

Integrated Remodeling of Gut-Liver Metabolism Induced by Moderate Protein Restriction Contributes to Improvement of Insulin Sensitivity

Xin Zhang et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2018)

Add to Collection

Article Genetics & Heredity

The fecal metabolome as a functional readout of the gut microbiome

Jonas Zierer et al.

NATURE GENETICS (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Lipopolysaccharide Modifies Glycerol Permeability and Metabolism in 3T3-L1 Adipocytes

Jeanne Durendale Chiadak et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Add to Collection

Article Cell Biology

Natural product celastrol suppressed macrophage M1 polarization against inflammation in diet-induced obese mice via regulating Nrf2/HO-1, MAP kinase and NF-κB pathways

Dan Luo et al.

AGING-US (2017)

Add to Collection

Article Medicine, Research & Experimental

Total sesquiterpene glycosides from Loquat (Eriobotrya japonica) leaf alleviate high-fat diet induced non-alcoholic fatty liver disease through cytochrome P450 2E1 inhibition

Tunyu Jian et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

Add to Collection

Review Biochemistry & Molecular Biology

Biological Activities of Extracts from Loquat (Eriobotrya japonica Lindl.): A Review

Yilong Liu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Add to Collection

Article Genetics & Heredity

Systematic genome assessment of B-vitamin biosynthesis suggests co-operation among gut microbes

Stefania Magnusdottir et al.

FRONTIERS IN GENETICS (2015)

Add to Collection

Article Biochemical Research Methods

Obesity-Dependent Metabolic Signatures Associated with Nonalcoholic Fatty Liver Disease Progression

J. Barr et al.

JOURNAL OF PROTEOME RESEARCH (2012)

Add to Collection

Article Agriculture, Multidisciplinary

Polyphenol Composition of a Functional Fermented Tea Obtained by Tea-Rolling Processing of Green Tea and Loquat Leaves

Takuya Shii et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2011)

Add to Collection

Article Agriculture, Multidisciplinary

Identification of α-glucosidase inhibitors from a new fermented tea obtained by tea-rolling processing of loquat (Eriobotrya japonica) and green tea leaves

Asami Toshima et al.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2010)

Add to Collection

Review Plant Sciences

Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus

WL Li et al.

JOURNAL OF ETHNOPHARMACOLOGY (2004)

Add to Collection

© Peeref 2019-2024. All rights reserved.