Total Sesquiterpenoids of Loquat Leaves Alleviated High-Fat Diet-Induced Obesity by Targeting Fecal Metabolic Profiling and Gut Microbiota Composition

In the present study, we demonstrated that whether the gut microbiota and related metabolites contribute to the therapeutic effect of total sesquiterpenoids (TSs) from loquat leaves on obesity. A 4-week high fat diet was used to induce obesity which was then treated with TSs for another 4 weeks. TSs remarkedly reduced the weight of body and white adipose and the levels of total cholesterol (TC) and triglyceride (TG) in serum. We also found that TSs restored the diversity and richness of gut microbiota. In addition, TSs administration affected the relative abundance of seven key genera. Meanwhile, TSs were determined to affect the metabolism of the host through detecting the metabolites in feces. By applying KEGG and the correlation analysis with gut microbiota, 10 differential metabolites were identified to be the key. The results in this work proved that TSs inhibited obesity by remodeling gut microbiota and related metabolites.

Automated summary

In this study, we demonstrated that total sesquiterpenoids (TSs) from loquat leaves can treat obesity by modulating gut microbiota and related metabolites. TSs reduced body weight, white adipose tissue, total cholesterol (TC), and triglyceride (TG) levels in the serum. They also restored the diversity and richness of gut microbiota and affected the metabolism of the host. By identifying key differential metabolites, we confirmed the role of TSs in inhibiting obesity.