Active mechanisms of ketamine-assisted psychotherapy: A systematic review

Article Psychiatry

Adjunctive Ketamine With Relapse Prevention-Based Psychological Therapy in the Treatment of Alcohol Use Disorder

Meryem Grabski et al.

Summary: This study suggests that ketamine may be a safe and effective treatment for alcohol use disorder, leading to increased abstinence. Additionally, combining ketamine with psychological therapy may have a beneficial effect.

AMERICAN JOURNAL OF PSYCHIATRY (2022)

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Article Psychology, Clinical

Spiritual Experiences in Psychedelic-Assisted Psychotherapy: Case Reports of Communion With the Divine, the Departed, and Saints in Research Using Psilocybin for the Treatment of Alcohol Dependence

Samantha K. Podrebarac et al.

Summary: Psychedelic substances have been used in religious and shamanic healing practices across cultures, and have shown promise in treating mental health issues in western medicine. There is growing evidence supporting the therapeutic potential of psychedelic-assisted psychotherapy and the importance of integrating spiritual aspects into traditional healing processes.

SPIRITUALITY IN CLINICAL PRACTICE (2021)

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Review Medicine, Research & Experimental

Strategies to Prolong Ketamine's Efficacy in Adults with Treatment-Resistant Depression

Eric P. McMullen et al.

Summary: This systematic review aimed to identify strategies capable of prolonging the acute efficacy of ketamine in adults with treatment-resistant depression. The study found that, other than repeat-dose IV ketamine, no treatment modality has demonstrated the ability to significantly prolong the acute efficacy of IV ketamine in TRD.

ADVANCES IN THERAPY (2021)

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Article Psychiatry

Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation

Roger S. McIntyre et al.

Summary: Replicated international studies have highlighted the human and societal costs of major depressive disorder, with monoamine-based antidepressants proving effective but many patients failing to fully recover. Ketamine and esketamine offer novel pharmacological treatments for treatment-resistant depression, but questions remain about their safety and effectiveness. International experts provide guidance on the use of these agents, while discussing areas of consensus and future research directions.

AMERICAN JOURNAL OF PSYCHIATRY (2021)

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Review Behavioral Sciences

Therapeutic potential of ketamine for alcohol use disorder

Stephen D. Worrell et al.

Summary: Excessive alcohol consumption in the US contributes to a significant number of deaths and financial burden each year. The complexity of Alcohol Use Disorder (AUD) involves neurotransmitter systems, synaptic plasticity, neurogenesis, and neural connectivity. Depressed mood and stress play crucial roles in AUD relapse, with comorbidity between AUD, depression, and stress disorders suggesting potential overlap in treatment approaches. Current pharmacotherapies for AUD have limitations, indicating the need for novel therapeutics like ketamine, which has shown promise in treating AUD, depression, and stress disorders.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2021)

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Article Psychiatry

Cognitive Behavioral Therapy to Sustain the Antidepressant Effects of Ketamine in Treatment-Resistant Depression: A Randomized Clinical Trial

Samuel T. Wilkinson et al.

Summary: This study aimed to investigate the feasibility and efficacy of CBT in maintaining the antidepressant effects of ketamine in TRD patients. The results showed that the CBT group had sustained improvement at the 14-week follow-up, and responders in the emotional N-back testing demonstrated cognitive improvement.

PSYCHOTHERAPY AND PSYCHOSOMATICS (2021)

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Review Psychiatry