Expanding role of ribosome-inactivating proteins: From toxins to therapeutics

Ribosome-inactivating proteins (RIPs) are toxic proteins with N-glycosidase activity. RIPs exert their action by removing a specific purine from 28S rRNA, thereby, irreversibly inhibiting the process of protein synthesis. RIPs can target both prokaryotic and eukaryotic cells. In bacteria, the production of RIPs aid in the process of pathogenesis whereas, in plants, the production of these toxins has been attributed to bolster defense against insects, viral, bacterial and fungal pathogens. In recent years, RIPs have been engineered to target a particular cell type, this has fueled various experiments testing the potential role of RIPs in many biomedical applications like anti-viral and anti-tumor therapies in animals as well as anti-pest agents in engineered plants. In this review, we present a comprehensive study of various RIPs, their mode of action, their significance in various fields involving plants and animals. Their potential as treatment options for plant infections and animal diseases is also discussed.

Automated summary

Ribosome-inactivating proteins (RIPs) are toxic proteins that inhibit protein synthesis by removing a specific purine from 28S rRNA. RIPs play a role in the pathogenesis of bacteria and defense against pathogens in plants. Recent experiments have shown the potential of engineered RIPs in biomedical applications such as antiviral and antitumor therapies, as well as pest control in engineered plants.