Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 214, Issue 12, Pages 1924-1928Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiw456
Keywords
microbiome; nasopharynx; respiratory syncytial virus; human rhinovirus; children
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Funding
- National Institute of Allergy and Infectious Diseases, NIH via the J. Craig Venter Institute Genomic Centers for Infectious Diseases Program [U19 AI095227, K24 AI77930]
- National Center for Advancing Transitional Sciences, NIH via the Vanderbilt Institute for Clinical and Translational Research [UL1 TR000445, U54 RR24975]
- NIH [HHSN272200900007C]
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Respiratory viruses alter the nasopharyngeal microbiome and may be associated with a distinct microbial signature. To test this hypothesis, we compared the nasopharyngeal microbiome of 135 previously healthy infants with acute respiratory infection due to human rhinovirus (HRV; n = 52) or respiratory syncytial virus (RSV; n = 83). The nasopharyngeal microbiome was assessed by sequencing the V4 region of the 16S ribosomal RNA. Respiratory viruses were identified by quantitative reverse-transcription polymerase chain reaction. We found significant differences in the overall taxonomic composition and abundance of certain bacterial genera between infants infected with HRV and those infected with RSV. Our results suggest that respiratory tract viral infections are associated with different nasopharyngeal microbial profiles.
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