Erythema nodosum with incidental calciphylaxis secondary to zoledronic acid and denosumab

Erythema nodosum (EN) is the most common clinical presentation of panniculitis, an inflammatory process that affects subcutaneous cellular tissue, characterized by the acute appearance of painful erythematous nodules predominantly in the lower extremities. An unusual case of EN is presented below, secondary to the administration of zoledronic acid (ZA) and denosumab, in which incidental histopathological findings of calciphylaxis were also found.

Automated summary

This is an unusual case of erythema nodosum (EN) associated with the administration of zoledronic acid (ZA) and denosumab, with incidental histopathological findings of calciphylaxis.