Journal
JOURNAL OF INFECTION
Volume 72, Issue 3, Pages 377-385Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/j.jinf.2015.12.011
Keywords
Complement system; Mannose-binding lectin; Ficolins
Categories
Funding
- FUNGINOS Foundation
- Leenaards Foundation
- Foundation for the Advancement in Medical Microbiology and Infectious Diseases
- bioMerieux
- Bio-Rad
- Essex Schering-Plough
- Novartis
- Pfizer
- Roche Diagnostics
- Associates of Cape Code
- European Community's Seventh Framework Program [Health-F2-2010-26033-ALLFUN]
- National Science Foundation [32003B-127613, 320030-144054]
- Santos-Suarez Foundation
- European Union's Seventh Framework Program [HEALTH-2010-260338]
- Astellas
- Gilead
- MSD
- Essex Schering-Plough Switzerland
- Gilead Switzerland
- Merck
- Sharp
- Pfizer Switzerland
- Dohme-Chibret Switzerland
- Novartis Switzerland
- Swiss National Science Foundation (SNF) [32003B_127613] Funding Source: Swiss National Science Foundation (SNF)
Ask authors/readers for more resources
Objectives: Human studies on the role of mannose-binding lectin (MBL) in patients with invasive candidiasis have yielded conflicting results. We investigated the influence of MBL and other lectin pathway proteins on Candida colonization and intra-abdominal candidiasis (IAC) in a cohort of high-risk patients. Methods: Prospective observational cohort study of 89 high-risk intensive-care unit (ICU) patients. Levels of lectin pathway proteins at study entry and six MBL2 single-nucleotide polymorphisms were analyzed by sandwich-type immunoassays and genotyping, respectively, and correlated with development of heavy Candida colonization (corrected colonization index (CCI) >= 0.4) and occurrence of IAC during a 4-week period. Results: Within 4 weeks after inclusion a CCI >= 0.4 and IAC was observed in 47% and 38% of patients respectively. Neither serum levels of MBL, ficolin-1, -2, -3, MASP-2 or collectin liver 1 nor MBL2 genotypes were associated with a CCI >= 0.4. Similarly, none of the analyzed proteins was found to be associated with IAC with the exception of lower MBL levels (HR 0.74, p = 0.02) at study entry. However, there was no association of MBL deficiency (<0.5 mu g/ml), MBL2 haplo-or genotypes with IAC. Conclusion: Lectin pathway protein levels and MBL2 genotype investigated in this study were not associated with heavy Candida colonization or IAC in a cohort of high-risk ICU patients. (C) 2015 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available