4.7 Review

Recent advances in pathophysiology and biomarkers of sepsis-induced acute kidney injury

Journal

JOURNAL OF INFECTION
Volume 72, Issue 2, Pages 131-142

Publisher

W B SAUNDERS CO LTD
DOI: 10.1016/j.jinf.2015.11.008

Keywords

Sepsis; Acute kidney injury; Sepsis-induced acute kidney injury; Sepsis pathophysiology; Microparticles; Prognostic markers

Funding

  1. Italian Society of Nephrology

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Sepsis is a complex clinical syndrome characterized by a systemic inflammatory response to an infective insult. This process often leads to widespread tissue injury and multiple organ dysfunction. In particular, the development of acute kidney injury (AKI) is one of the most frequent complications, which increases the complexity and cost of care, and is an independent risk factor for mortality. Previous suggestions highlighting systemic hypotension, renal vasoconstriction and ischaemia-reperfusion injury as the primary pathophysiological mechanisms involved in sepsis-induced AKI have been challenged. Recently it has been shown that sepsis-induced AKI occurs in the setting of microvascular dysfunction with release of microparticles, inflammation and energetic adaptation of highly metabolic organs to cellular stress. The intolerable high mortality rate associated with sepsis-induced AKI is partially explained by an incomplete understanding of its pathophysiology and a delay in diagnosis. The aim of this review is to focus on advances in understanding the sepsis pathophysiology, with particular attention to the fundamental mechanisms of sepsis-induced AKI and the potential diagnostic and prognostic markers involved. (C) 2015 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

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