☆ 4.3 Article

Recent advances in polymeric hydrogel nanoarchitectures for drug delivery applications

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS (2024)

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JOURNAL OF MATERIALS SCIENCE (2022)

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Article Chemistry, Physical

Sulfasalazine/Nimesulide dual-loaded halloysite based poly (sulfobetaine methacrylate) hydrogels: Development and drug release characteristics

Fulya Taktak et al.

Summary: Co-administration of two or more drugs has been shown to be a viable option for treating diseases such as rheumatoid arthritis. Different kinetic models were studied to fit single and combined drug release kinetics.

JOURNAL OF MOLECULAR STRUCTURE (2022)

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Article Polymer Science

A novel stimuli-responsive magnetic hydrogel based on nature-inspired tragacanth gum for chemo/hyperthermia treatment of cancerous cells

Ali Khani et al.

Summary: An efficient and facile bioinspired drug delivery system was successfully developed based on tragacanth gum, which was modified to form a pH- and reduction-sensitive magnetic hydrogel. The system exhibited excellent drug encapsulation efficiency and potential for cancer treatment.

JOURNAL OF POLYMER RESEARCH (2022)

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Article Polymer Science

Synthesis of gum acacia-silver nanoparticles based hydrogel composites and their comparative anti-bacterial activity

Karanpreet Virk et al.

Summary: An interpenetrating polymer network (IPN) containing gum acacia, poly(methacrylic acid), and poly(acrylic acid) was developed, and the swelling percentage of the semi-IPN was optimized by varying reaction parameters. An IPN was then created by grafting AA chains onto the optimized semi-IPN and was used as a template for loading silver nanoparticles. The synthesized systems exhibited antibacterial activity against various bacteria strains.

JOURNAL OF POLYMER RESEARCH (2022)

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Article Chemistry, Applied

Biobased thermo/pH sensitive poly(N-isopropylacrylamide-co-crotonic acid) hydrogels for targeted drug delivery

Maja D. Markovic et al.

Summary: Materials sensitive to external stimuli are considered safe and effective tools in responding to specific demands in disease therapy. Thermo sensitive hydrogels based on poly(N-isopropylacrylamide) (P(NIPAAM)) have been extensively studied for targeted drug delivery. However, the abundance of stimuli in the human body often requires multiple responsive groups to act simultaneously for optimal therapeutic effects.

MICROPOROUS AND MESOPOROUS MATERIALS (2022)

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Article Nanoscience & Nanotechnology

Macrophage-targeted shikonin-loaded nanogels for modulation of inflammasome activation

Matias Cardoso et al.

Summary: This study demonstrates the formulation of hyaluronic acid-Zein nanogels loaded with Shikonin to selectively attenuate macrophage inflammasome. The nanogels exhibit high encapsulation efficiency and are selectively internalized by macrophages without cytotoxic responses. The treatment with these nanogels inhibits caspase-1 activation and IL-1 beta production, leading to an anti-inflammatory phenotype and a decrease in pro-inflammatory mediators.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2022)

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Article Oncology

Design of an efficient fluorescent nanoplatform carrier for hydrophobic drugs along with green carbon dot: Possible application in cancer image-guided drug therapy

Fatemeh Hashemi et al.

Summary: This study presents a biocompatible and affordable fluorescence nanocarrier for cell imaging in cancer therapy. The hybrid nanogel, composed of chitosan polymer, carbon dots (CDs), and an anti-cancer drug, demonstrated successful uptake into breast cancer cells and efficient drug release. The nanocarrier provides both therapeutic compounds and fluorescent agents, enhancing therapeutic efficacy and enabling cellular imaging.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2022)

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Review Nanoscience & Nanotechnology

Nanocarrier-hydrogel composite delivery systems for precision drug release

Lauren E. Kass et al.

Summary: Hydrogels are widely used in medical applications due to their biocompatibility and biodegradability, but challenges such as burst release, limited drug encapsulation capabilities, and poor control of drug release geometry and shape remain. Recent advances in incorporating nanocarriers and utilizing 3D printing have shown promise in enhancing the precision of drug release from hydrogels.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2022)

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Review Nanoscience & Nanotechnology

One stone, many birds: Recent advances in functional nanogels for cancer nanotheranostics

Huiyi Wang et al.

Summary: Inspired by the development of nanomedicine and nanotechnology, the field of cancer theranostics has seen significant progress in recent years. Nanogels, with their unique attributes such as high stability and encapsulation capacity, have been extensively studied for drug delivery and various bioimaging techniques.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2022)

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Article Chemistry, Multidisciplinary

β-cyclodextrin/alginate nanoparticles encapsulated 5-fluorouracil as an effective and safe anticancer drug delivery system

Cao-Hien Nguyen et al.

Summary: In this study, beta-cyclodextrin/alginate nanoparticles loaded with 5-fluorouracil (5-FU) were prepared and evaluated for their release properties and bioactivity in different pH media. The nanoparticles exhibited good loading efficiency and encapsulation efficiency. The release profile of 5-FU was influenced by the pH of the media, and the nanoparticles showed strong antiproliferative activity against cancer cells with minimal effects on normal cells.

ARABIAN JOURNAL OF CHEMISTRY (2022)

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Article Materials Science, Multidisciplinary

Engineered nanogels simultaneously implement HDAC inhibition and chemotherapy to boost antitumor immunity via pyroptosis

De-Run Chen et al.

Summary: Regulating the immunosuppressive status of the tumor immune microenvironment is challenging. Pyroptosis shows potential in tumor immune therapy by recruiting immune cells. This study designed a nanogel-based prodrug to reshape tumor immunity, resulting in increased immune cell numbers and improved response rate to anti-PD-1 therapy.

APPLIED MATERIALS TODAY (2022)

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Article Materials Science, Multidisciplinary

Synergistic effect of chemical crosslinking and addition of graphene-oxide in Chitosan-Hydrogels, films, and drug delivery

Sai Geetha Marapureddy et al.

Summary: This study investigates the synergistic effect of Glutaraldehyde (GA) chemical crosslinking and Graphene Oxide (GO) physical crosslinking on Chitosan (CH) to enhance the mechanical strength of CH hydrogels and films. The results show that increasing the loading of GA and GO leads to improved storage modulus and yield stress values. Additionally, the morphology studies reveal improved porosity in CH-GA and CH-GO-GA hydrogels with increased GA and GO loading. The incorporation of GO nanosheets in CH-GA hydrogel films significantly increases their Young's modulus. Drug delivery studies demonstrate that the CH-GO-GA film exhibits pH-responsive behavior and sustained drug release.

MATERIALS TODAY COMMUNICATIONS (2022)

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Article Materials Science, Multidisciplinary

Folate-conjugated thermal- and pH-responsive magnetic hydrogel as a drug delivery nano-system for smart chemo/hyperthermia therapy of solid tumors

Hossein Derakhshankhah et al.

Summary: A folate-conjugated pH- and thermal-sensitive magnetic hydrogel was developed as a smart drug delivery system for chemo/hyperthermia therapy of cancer cells. The hydrogel showed suitable drug loading and encapsulation efficiencies, and exhibited pH- and thermal-responsive drug release behavior under tumor conditions. The developed drug delivery system demonstrated synergistic cancer therapy by combining chemotherapy and hyperthermia approaches.

MATERIALS TODAY COMMUNICATIONS (2022)

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Review Biotechnology & Applied Microbiology

Nanocomposite hydrogels for biomedical applications

Shanghui Huang et al.

Summary: Nanomaterials and hydrogels have significant application value in biomedicine. Nanocomposite hydrogel systems can overcome their respective shortcomings and have broad prospects for application.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2022)

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Article Chemistry, Physical

Smart pH-responsive drug release systems based on functionalized chitosan nanocomposite hydrogels

Zahra Shariatinia et al.

Summary: Chitosan was functionalized and utilized as smart pH-responsive drug delivery systems for the anticancer drug cyclophosphamide. Different synthesized materials showed varied drug release rates under different pH conditions, with CS-AC-U-CP being identified as the most desirable DDS.

SURFACES AND INTERFACES (2022)

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Review Chemistry, Multidisciplinary

Review on the biomedical and sensing applications of nanomaterial-incorporated hydrogels

Suresh Kumar Kailasa et al.

Summary: Hydrogel nanocomposites, as 'smart materials', have gained recognition due to their stable three-dimensional polymeric structures and enhanced properties. This review summarizes the synthetic approaches for preparing nanomaterial-integrated hydrogels and discusses their applications in biomedical sciences and sensing. The future prospects of hybrid hydrogels in multidisciplinary research are also discussed.

MATERIALS TODAY CHEMISTRY (2022)

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Article Chemistry, Applied

Carboxymethyl konjac glucomannan-chitosan complex nanogels stabilized double emulsions incorporated into alginate hydrogel beads for the encapsulation, protection and delivery of probiotics

Xiaoqing Ding et al.

Summary: In this study, double emulsions encapsulated by calcium-alginate hydrogel beads system (ACGs) were developed for intestinal-targeted delivery of probiotics. The experimental results showed that ACG-2 and ACG-3 hydrogel beads had sustained release properties in simulated intestinal fluid and high cell viability. Moreover, the alginate concentration in ACGs hydrogel beads influenced the swelling behavior and structure, thus mediating the release of probiotics.

CARBOHYDRATE POLYMERS (2022)

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Proceedings Paper Materials Science, Multidisciplinary

A mini-review on the application of machine learning in polymer nanogels for drug delivery

Oluwasegun Chijioke Adekoya et al.

Summary: The advent of nanotechnology has led to significant advancements in drug delivery systems, particularly in the use of nanogels as effective polymeric materials. These nanosized hydrogels, ranging from 100 to 200 nm, are non-toxic, biocompatible, and biodegradable, making them suitable for drug delivery. Recent studies have demonstrated that machine learning can optimize the drug-carrying and delivery capabilities of nanogels. This review aims to explore the mechanisms of nanogel drug delivery, commonly used machine learning models, potential applications of machine learning in nanogel drug delivery, and the limitations of using machine learning in this context.

MATERIALS TODAY-PROCEEDINGS (2022)

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Review Polymer Science

A review on polyaniline and graphene nanocomposites for supercapacitors

Christopher Igwe Idumah

Summary: This article presents the recent advancements in the synthesis, fabrication, and characterization of PANI@graphene hybrid nanocomposites for energy storage applications, with a focus on PANI@GN, PANI@GO, and PANI@r-GO. The market structures are also discussed.

POLYMER-PLASTICS TECHNOLOGY AND MATERIALS (2022)

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Article Materials Science, Biomaterials

Nanogels loading curcumin in situ through microemulsion photopolymerization for enhancement of antitumor effects

Yuanyuan Peng et al.

Summary: The study demonstrates that drug-loaded nanogels with curcumin exhibit significant cytotoxicity towards cancer cells, effectively inhibiting tumor growth and showing stronger suppression in tumor-bearing nude mice compared to curcumin.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Article Polymer Science

Orally Administered, Biodegradable and Biocompatible Hydroxypropyl-β-Cyclodextrin Grafted Poly(methacrylic acid) Hydrogel for pH Sensitive Sustained Anticancer Drug Delivery

Nighat Batool et al.

Summary: In this study, a pH sensitive intelligent hydrogel was developed for site-specific delivery of cytarabine in the colonic region. The hydrogel demonstrated excellent drug loading capability, controlled release behavior, and biocompatibility, making it a potential candidate for the treatment of colon cancer.

GELS (2022)

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Article Biochemistry & Molecular Biology

Controlled Liposome Delivery from Chitosan-Based Thermosensitive Hydrogel for Regenerative Medicine

Franco Furlani et al.

Summary: This work presents the development of an injectable nanocomposite system for regenerative medicine, combining chitosan thermosensitive hydrogel and liposomes. The system allows controlled release, enhances cellular uptake, and can form a hydrogel at physiological temperature.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Polymer Science

Curcuminoid Co-Loading Platinum Heparin-Poloxamer P403 Nanogel Increasing Effectiveness in Antitumor Activity

Ngoc The Nguyen et al.

Summary: This study successfully developed a nanogel capable of co-loading curcuminoid and cisplatin hydrate, demonstrating high stability and accelerated drug release. In vitro and in vivo experiments confirmed the significant antitumor activity and prolonged survival time achieved by the dual-drug platform.

GELS (2022)

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Article Polymer Science

Drug Delivery Based on Stimuli-Responsive Injectable Hydrogels for Breast Cancer Therapy: A Review

Hai Xin et al.

Summary: Breast cancer is a major health threat for women, and there is a need for novel therapies to overcome the limitations of conventional treatments. Injectable hydrogels as drug delivery systems have gained attention recently for their potential to improve treatment efficacy and reduce side effects by providing localized and controlled drug release at the tumor site.

GELS (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

3D printing of nanocomposite pills through desktop vat photopolymerization (stereolithography) for drug delivery reasons

Peeyush Kumar Sharma et al.

Summary: In this study, a 3D printed nanocomposite pill was developed using the desktop vat polymerization process for drug delivery applications. The results showed successful fabrication of high fidelity monoliths using photopolymerized resin, with hydrogel nanoparticles entrapped within the pills. The nanocomposite pills exhibited higher swelling and faster drug release in an acidic environment.

3D PRINTING IN MEDICINE (2022)

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Article Materials Science, Multidisciplinary

Magnetoresponsive biocomposite hydrogels comprising gelatin and valine based magnetic ionic liquid surfactant as controlled release nanocarrier for drug delivery

Akshay Kulshrestha et al.

Summary: This study successfully prepared magnetoresponsive biocomposite hydrogels by combining a biopolymer with a magnetic ionic liquid surfactant, demonstrating promising drug delivery carrier effects. Various tests confirmed the characteristics of vesicle structure, biocompatibility, and drug encapsulation efficiency of the hydrogels, showing their potential for advanced drug delivery applications. Additionally, the hydrogels exhibited good results in terms of drug encapsulation efficiency and magnetic responsiveness.

MATERIALS ADVANCES (2022)

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Article Thermodynamics

Recent advancements in thermolysis of plastic solid wastes to liquid fuel

Christopher Igwe Idumah

Summary: Plastics have shown rapid growth in domestic and industrial usage due to their flexibility and lower cost, but their short shelf-life, disposal difficulty, and increasing costs have led to serious environmental challenges, prompting the need for alternative disposal methods. Green biodegradable polymers have not been able to meet the high demand for plastics, leading to continued use of petroleum-based polymers in various applications. Plastics recycling has evolved through various technologies, showing potential to conserve natural resources and reduce waste.

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY (2022)

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Review Materials Science, Composites

Novel trends in self-healable polymer nanocomposites

C. I. Idumah

Summary: Polymer composites for structural applications are prone to damage from cracks, which can lead to mechanical deterioration and electrical failure. Self-healing composites, inspired by biological systems, have the capability to automatically recover from damage. Stretchable electronics offer the ability to conform to irregular structures and biological tissues, enabling movement and flexibility. This article highlights recent advancements in self-healing composites, stretchable composites, and sensors, as well as future market trends and applications.

JOURNAL OF THERMOPLASTIC COMPOSITE MATERIALS (2021)

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Article Materials Science, Characterization & Testing

Recent advancements in self-healing polymers, polymer blends, and nanocomposites

Christopher I. Idumah

Summary: Polymer composites used for structural applications are vulnerable to damage caused by deep cracks, leading to mechanical and electrical failures. Self-healing composites, inspired by biological systems, can automatically recover from damage, providing a solution to the challenge of material cracking.

POLYMERS & POLYMER COMPOSITES (2021)

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Article Materials Science, Characterization & Testing

Progress in polymer nanocomposites for bone regeneration and engineering

Christopher Igwe Idumah

Summary: The ultimate goal of tissue engineering is to create functional replacements for damaged organs or tissues, with scaffolds playing a crucial role in promoting tissue regeneration. Polymer nanocomposites show potential in bone scaffold fabrication due to their ability to enhance mechanical behavior through inclusion of fibers or nanoparticles.

POLYMERS & POLYMER COMPOSITES (2021)

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Article Chemistry, Physical

Emerging trends in polymer aerogel nanoarchitectures, surfaces, interfaces and applications

Christopher Igwe Idumah et al.

Summary: The current pursuit of aerogel nanocomposites is driven by their unique properties and applications, but hindered by high costs and mechanical limitations. However, nanotechnology offers solutions to these issues and enhances the functional potential for multidisciplinary research.

SURFACES AND INTERFACES (2021)

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Article Polymer Science

Understanding interfacial dispersions in ecobenign polymer nano-biocomposites

Chistopher Igwe Idumah et al.

Summary: The emergence of nanotechnology has led to the development of polymer fiber nano-biocomposites by hybridizing nanomaterials like graphene, carbon nanotubes, and nanoclay with natural fibers. These materials exhibit enhanced properties such as thermal stability, electrical and thermal conductivity, reduced thermal expansion, heat deflection temperature, and flame retardancy, expanding their application in various industries.

POLYMER-PLASTICS TECHNOLOGY AND MATERIALS (2021)

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Review Materials Science, Textiles

Influence of nanotechnology in polymeric textiles, applications, and fight against COVID-19

Christopher Igwe Idumah

Summary: Nanotechnology in textiles has expanded into various applications, enhancing the functionality and physicochemical behaviors of textiles for diverse fields. In the era of COVID-19, nanotechnology has played a crucial role in improving personal protective equipment and antiviral capabilities.

JOURNAL OF THE TEXTILE INSTITUTE (2021)

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Review Polymer Science

A review: advancements in conductive polymers nanocomposites

Christopher Igwe Idumah et al.

Summary: Conductive polymers and their nanocomposites offer numerous advantages, with hybridization with nanomaterials resulting in multifunctional nanocomposites with enhanced performance for various devices. Research focuses on synthesis, characterization, properties, novel applications, and market structures.

POLYMER-PLASTICS TECHNOLOGY AND MATERIALS (2021)

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Review Materials Science, Multidisciplinary

Novel trends in conductive polymeric nanocomposites, and bionanocomposites

Christopher Igwe Idumah

Summary: Conducting polymer composites and nanocomposites are developed to enhance material performances, while conducting polymer bionanocomposites find applications in biomedical and food engineering due to their biocompatibility, biodegradability, and electrical conductivity.

SYNTHETIC METALS (2021)

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Article Chemistry, Physical

Understanding interfacial influence on properties of polymer nanocomposites

Christopher Igwe Idumah et al.

Summary: Polymer nanocomposites, plant fiber reinforced polymer biocomposites, and nanobiocomposites have versatile applications in various industries, with composite behavior highly dependent on the properties of its constituting components. Interfacial interactions between polymer matrices and nanofillers play a crucial role in influencing nanocomposite behavior.

SURFACES AND INTERFACES (2021)

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Article Chemistry, Physical

Effect of surface decoration on properties and drug release ability of nanogels

Filippo Pinelli et al.

Summary: This study investigated the impact of different surface functionalization strategies on the same PEG-PEI nanogel framework, revealing variations in properties such as diameter, zeta-potential, and drug release ability. Additionally, the cytocompatibility of the final nano-carrier and molecular surface features were evaluated at a microscopic level.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2021)

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Review Materials Science, Multidisciplinary

Trends in reinforced composite design for ionizing radiation shielding applications: a review

Christian Emeka Okafor et al.

Summary: Reinforced composite materials have great potential in radiation shielding due to their lightweight, low cost, high resilience, good mechanical tenacity, and interesting electrical properties. Recent literature has criticized the continued use of lead for radiation shielding due to its drawbacks such as high toxicity, poisoning, lack of stability, heaviness, and hazardous afterlife handling.

JOURNAL OF MATERIALS SCIENCE (2021)

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Article Polymer Science

Novel trends in polymer aerogel nanocomposites

Christopher Igwe Idumah

Summary: Aerogel is a porous ultra-light material made from gel substrates, with the liquid portion of the gel replaced by gas, resulting in a solid with very low heat dissipating behavior and low density. The embedding of nanomaterials within aerogel has led to the formation of lightweight, high-performing, and multifunctional aerogel nanostructures, thanks to advancements in nanotechnology. This paper explores the properties and features of aerogel and aerogel nanocomposites that facilitate their application in various fields.

POLYMER-PLASTICS TECHNOLOGY AND MATERIALS (2021)

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Article Materials Science, Composites

Electrical, thermal and flammability properties of conductive filler kenaf-reinforced polymer nanocomposites

Christopher Igwe Idumah et al.

JOURNAL OF THERMOPLASTIC COMPOSITE MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Zwitterionic Polysulfamide Drug Nanogels with Microwave Augmented Tumor Accumulation and On-Demand Drug Release for Enhanced Cancer Therapy

Shaojun Peng et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Polymer Science

Nanocomposite Cryogel Carriers from 2-Hydroxyethyl Cellulose Network and Cannabidiol-Loaded Polymeric Micelles for Sustained Topical Delivery

Denitsa Momekova et al.

POLYMERS (2020)

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Review Pharmacology & Pharmacy

An Updated Review of Macro, Micro, and Nanostructured Hydrogels for Biomedical and Pharmaceutical Applications

Caroline S. A. de Lima et al.

PHARMACEUTICS (2020)

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Review Infectious Diseases

A Review on Revolutionary Natural Biopolymer-Based Aerogels for Antibacterial Delivery

Esam Bashir Yahya et al.

ANTIBIOTICS-BASEL (2020)

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Article Chemistry, Physical

Recently Emerging Nanotechnological Advancements in Polymer Nanocomposite Coatings for Anti-corrosion, Anti-fouling and Self-healing

Christopher Igwe Idumah et al.

SURFACES AND INTERFACES (2020)

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Review Polymer Science

Radical polymerization as a versatile tool for surface grafting of thin hydrogel films

Farzad Seidi et al.

POLYMER CHEMISTRY (2020)

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Review Polymer Science

Nanoparticle-Hydrogel Composites: From Molecular Interactions to Macroscopic Behavior

Corinna Dannert et al.

POLYMERS (2019)

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Review Engineering, Biomedical

Stimulus-responsive polymeric nanogels as smart drug delivery systems

Sakineh Hajebi et al.

ACTA BIOMATERIALIA (2019)

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Article Polymer Science

Polyurethane/poly(vinyl alcohol) hydrogels: Preparation, characterization and drug delivery

Mihaela Mandru et al.

EUROPEAN POLYMER JOURNAL (2019)

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Article Chemistry, Multidisciplinary

Nanogels and Microgels: From Model Colloids to Applications, Recent Developments, and Future Trends

Matthias Karg et al.

LANGMUIR (2019)

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Article Materials Science, Biomaterials

Biodegradable and injectable hydrogels as an immunosuppressive drug delivery system

Han-Sem Kim et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Article Nanoscience & Nanotechnology

Self-assembled insulin and nanogels polyelectrolyte complex (Ins/NGs-PEC) for oral insulin delivery: characterization, lyophilization and in-vivo evaluation

Jahanzeb Mudassir et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Review Chemistry, Multidisciplinary

Crossing biological barriers with nanogels to improve drug delivery performance

Julio Cesar Cuggino et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Review Chemistry, Multidisciplinary

Nanogels for regenerative medicine

Maria Aurora Grimaudo et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Article Pharmacology & Pharmacy

Platelets membrane camouflaged irinotecan-loaded gelatin nanogels for in vivo colorectal carcinoma therapy

Liwei Xu et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2019)

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Review Engineering, Biomedical

Overview of natural hydrogels for regenerative medicine applications

Marta Calvo Catoira et al.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2019)

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Review Polymer Science

Functional Hydrogels and Their Application in Drug Delivery, Biosensors, and Tissue Engineering

Ke Wang et al.

INTERNATIONAL JOURNAL OF POLYMER SCIENCE (2019)

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Review Materials Science, Composites

Recently emerging advancements in halloysite nanotubes polymer nanocomposites

Christopher Igwe Idumah et al.

COMPOSITE INTERFACES (2019)

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Review Biochemistry & Molecular Biology

siRNA Conjugated Nanoparticles-A Next Generation Strategy to Treat Lung Cancer

Rasha Itani et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Multidisciplinary Sciences

Influence of chemical modification of kenaf fiber on xGNP-PP nano-biocomposites

Christopher Igwe Idumah et al.

SN APPLIED SCIENCES (2019)

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Review Chemistry, Multidisciplinary

Magneto-Responsive Hydrogels: Preparation, Characterization, Biotechnological and Environmental Applications

Emilli C. G. Frachini et al.

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY (2019)

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Review Biology

Synthetic Approaches for Nucleic Acid Delivery: Choosing the Right Carriers

Rong Ni et al.

LIFE-BASEL (2019)

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Review Polymer Science

Recently emerging trends in polymer nanocomposites packaging materials

Christopher Igwe Idumah et al.

POLYMER-PLASTICS TECHNOLOGY AND MATERIALS (2019)

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Article Biochemistry & Molecular Biology

Folic acid conjugated bovine serum albumin: An efficient smart and tumor targeted biomacromolecule for inhibition folate receptor positive cancer cells

Named Nosrati et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Article Nanoscience & Nanotechnology

Targeting Delivery of Rapamycin with Anti-Collagen IV Peptide Conjugated Fe3O4 @ Nanogels System for Vascular Restenosis Therapy

Qian Yang et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2018)

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Review Materials Science, Biomaterials

A review of recent progress in drug and protein encapsulation: Approaches, applications and challenges

Chen Ye et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

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Article Thermodynamics

Synergistic effect of exfoliated graphene nanoplatelets and non-halogen flame retardants on flame retardancy and thermal properties of kenaf flour-PP nanocomposites

Christopher Igwe Idumah et al.

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY (2018)

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Review Polymer Science

Nanocomposite Hydrogels: Advances in Nanofillers Used for Nanomedicine

Arti Vashist et al.

GELS (2018)

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Article Chemistry, Analytical

Influence of exfoliated graphene nanoplatelets on flame retardancy of kenaf flour polypropylene hybrid nanocomposites

Christopher Igwe Idumah et al.

JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS (2017)

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Review Chemistry, Multidisciplinary

Nanogels for intracellular delivery of biotherapeutics

Dandan Li et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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Article Materials Science, Textiles

Hibiscus Cannabinus Fiber/PP based Nano-Biocomposites Reinforced with Graphene Nanoplatelets

Christopher Igwe Idumah et al.

JOURNAL OF NATURAL FIBERS (2017)

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Review Chemistry, Multidisciplinary

Functional Microgels and Microgel Systems

Felix A. Plamper et al.

ACCOUNTS OF CHEMICAL RESEARCH (2017)

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Article Chemistry, Multidisciplinary

Self-Assembled Smart Nanocarriers for Targeted Drug Delivery

Wei Cui et al.

ADVANCED MATERIALS (2016)

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Article Chemistry, Multidisciplinary

Nanogels: An overview of properties, biomedical applications and obstacles to clinical translation

Kruti S. Soni et al.

JOURNAL OF CONTROLLED RELEASE (2016)

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Article Polymer Science

Effect of exfoliated graphite nanoplatelets on thermal and heat deflection properties of kenaf polypropylene hybrid nanocomposites

Christopher Igwe Idumah et al.

JOURNAL OF POLYMER ENGINEERING (2016)

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Article Chemistry, Multidisciplinary

Biodegradable Smart Nanogels: A New Platform for Targeting Drug Delivery and Biomedical Diagnostics

Hai-Qiu Wu et al.

LANGMUIR (2016)

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Review Materials Science, Biomaterials

New progress and prospects: The application of nanogel in drug delivery

Hui Zhang et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2016)

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Review Engineering, Chemical

Recently emerging trends in thermal conductivity of polymer nanocomposites

Christopher Igwe Idumah et al.

REVIEWS IN CHEMICAL ENGINEERING (2016)

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Review Engineering, Chemical

Emerging trends in graphene carbon based polymer nanocomposites and applications

Christopher Igwe Idumah et al.

REVIEWS IN CHEMICAL ENGINEERING (2016)

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Article Materials Science, Multidisciplinary

Characterization and preparation of conductive exfoliated graphene nanoplatelets kenaf fibre hybrid polypropylene composites

Christopher Igwe Idumah et al.

SYNTHETIC METALS (2016)

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Article Engineering, Biomedical

Controlled release of bioactive PDGF-AA from a hydrogel/nanoparticle composite

Irja Elliott Donaghue et al.

ACTA BIOMATERIALIA (2015)

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Article Chemistry, Multidisciplinary

In-Situ Formation of Growth-Factor-Loaded Coacervate Microparticle-Embedded Hydrogels for Directing Encapsulated Stem Cell Fate

Oju Jeon et al.

ADVANCED MATERIALS (2015)

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Article Chemistry, Multidisciplinary

Hybrid Crosslinked Methylcellulose Hydrogel: A Predictable and Tunable Platform for Local Drug Delivery

Malgosia M. Pakulska et al.

ADVANCED MATERIALS (2015)

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Review Biotechnology & Applied Microbiology

Polymer-based nanoparticles for oral insulin delivery: Revisited approaches

Pedro Fonte et al.

BIOTECHNOLOGY ADVANCES (2015)

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Article Chemistry, Applied

Manipulation the behavior of supramolecular hydrogels of ot-cyclodextrin/star-like block copolymer/carbon-based nanomaterials

Jinglin Shen et al.

CARBOHYDRATE POLYMERS (2015)

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Article Chemistry, Applied

Magnetic/pH-responsive beads based on caboxymethyl chitosan and κ-carrageenan and controlled drug release

Gholam Reza Mandavinia et al.

CARBOHYDRATE POLYMERS (2015)

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Review Chemistry, Multidisciplinary

Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery

Yulin Li et al.

CHEMICAL REVIEWS (2015)

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Article Biophysics

Controllable promotion of chondrocyte adhesion and growth on PVA hydrogels by controlled release of TGF-β1 from porous PLGA microspheres

Lei Nie et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2015)

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Novel dual-reverse thermosensitive solid lipid nanoparticle-loaded hydrogel for rectal administration of flurbiprofen with improved bioavailability and reduced initial burst effect

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EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2015)

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Development of an injectable PHBV microparticles-GG hydrogel hybrid system for regenerative medicine

Daniela P. Pacheco et al.

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Injectable nanoparticle-loaded hydrogel system for local delivery of sodium alendronate

Urszula Posadowska et al.

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Designing a biocompatible hydrogel for the delivery of mesalamine

Lena Neufeld et al.

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Effect of liposomes on rheological and syringeability properties of hyaluronic acid hydrogels intended for local injection of drugs

Naila El Kechai et al.

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Nanocomposite Hydrogels and Their Applications in Drug Delivery and Tissue Engineering

Fangfang Song et al.

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Dendrimer complexed hydrogel for local delivery of PTX to inhibit recurrence of breast cancer

Jingjing Hu et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Multiple tissue response modifiers to promote angiogenesis and prevent the foreign body reaction around subcutaneous implants

Michail Kastellorizios et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Soft Confinement of Graphene in Hydrogel Matrixes

Yosra Toumia et al.

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Nanocomposite hydrogel consisting of Na-montmorillonite with enhanced mechanical properties

Ting Li et al.

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Influence of crosslinker amount on swelling and gel properties of hectorite/poly(acrylamide/itaconic acid) nanocomposite hydrogels

Tao Wan et al.

KOREAN JOURNAL OF CHEMICAL ENGINEERING (2015)

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Thermosensitive hydrogel drug delivery system containing doxorubicin loaded CS - GO nanocarriers for controlled release drug in situ

Q. F. Guo et al.

MATERIALS TECHNOLOGY (2015)

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Hectorite effects on swelling and gel properties of hectorite/poly(AM/IA) nanocomposite hydrogels

Tao Wan et al.

POLYMER BULLETIN (2015)

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Synthesis of electroconductive hydrogel films by an electro-controlled click reaction and their application to drug delivery systems

Eun Jung Choi et al.

POLYMER CHEMISTRY (2015)

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A review of recent developments in flammability of polymer nanocomposites

Christopher Igwe Idumah et al.

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Self-assembled hydrogels utilizing polymer-nanoparticle interactions

Eric A. Appel et al.

NATURE COMMUNICATIONS (2015)

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On demand delivery of ionic drugs from electro-responsive CNT hybrid films

M. Curcio et al.

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Fabrication of acrylic acid grafted guar gum-multiwalled carbon nanotube hydrophobic membranes for transdermal drug delivery

Arindam Giri et al.

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Synthesis of a novel pH responsive phyllosilicate loaded polymeric hydrogel based on poly(acrylic acid-co-N-vinylpyrrolidone) and polyethylene glycol for drug delivery: modelling and kinetics study for the sustained release of an antibiotic drug

Sayan Ganguly et al.

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A combination hydrogel microparticle-based vaccine prevents type 1 diabetes in non-obese diabetic mice

Young Mee Yoon et al.

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Composites of Polymer Hydrogels and Nanoparticulate Systems for Biomedical and Pharmaceutical Applications

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Enhanced electrochemical stimuli multilayers based on a ferrocene-containing polymer

Yi-Xin Sun et al.

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Characterization, Formation Mechanisms, and pH-Sensitive Drug Release Behavior

Yongzhe Piao et al.

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Hydrogel Doped with Nanoparticles for Local Sustained Release of siRNA in Breast Cancer

Nathaly Segovia et al.

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Dual stimulus responsive drug release under the interaction of pH value and pulsatile electric field for a bacterial cellulose/sodium alginate/multi-walled carbon nanotube hybrid hydrogel

Xiangning Shi et al.

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Effects of different rhBMP-2 release profiles in defect areas around dental implants on bone regeneration

Jae Ho Jo et al.

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On the Mechanism of Drug Release from Polysaccharide Hydrogels Cross-Linked with Magnetite Nanoparticles by Applying Alternating Magnetic Fields: the Case of DOXO Delivery

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GELS (2015)

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Preparation and Characterization of Organic-Inorganic Composite Materials Based on Poly(acrylamide) Hydrogels and Clay Minerals

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Injectable Dopamine-Modified Poly(ethylene glycol) Nanocomposite Hydrogel with Enhanced Adhesive Property and Bioactivity

Yuan Liu et al.

ACS APPLIED MATERIALS & INTERFACES (2014)

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Hydrogel Containing Nanoparticle-Stabilized Liposomes for Topical Antimicrobial Delivery

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ACS NANO (2014)

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Multifunctional hydrogel-based scaffold for improving the functionality of encapsulated therapeutic cells and reducing inflammatory response

Argia Acarregui et al.

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Application of Taguchi Method to Investigate the Drug Release Behavior of Poly(Acrylamide-co-Maleic Acid)/Montmorillonite Nanocomposite Hydrogels

Daniyal Dadkhah et al.

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PEG-PCL based micelle hydrogels as oral docetaxel delivery systems for breast cancer therapy

YuJun Wang et al.

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Click hydrogels, microgels and nanogels: Emerging platforms for drug delivery and tissue engineering

Yanjiao Jiang et al.

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Thermoresponsive magnetic nanoparticle - Aminated guar gum hydrogel system for sustained release of doxorubicin hydrochloride

Ragothaman Murali et al.

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Near-infrared light triggerable deformation-free polysaccharide double network hydrogels

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Targeted delivery of doxorubicin into tumor cells via MMP-sensitive PEG hydrogel-coated magnetic iron oxide nanoparticles (MIONPs)

Caner Nazli et al.

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Controlled release of anticancer drug using graphene oxide as a drug-binding effector in konjac glucomannan/sodium alginate hydrogels

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A study of chitosan hydrogel with embedded mesoporous silica nanoparticles loaded by ibuprofen as a dual stimuli-responsive drug release system for surface coating of titanium implants

Pengkun Zhao et al.

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Biodegradable gelatin-ciprofloxacin-montmorillonite composite hydrogels for controlled drug release and wound dressing application

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RAFT controlled synthesis of graphene/polymer hydrogel with enhanced mechanical property for pH-controlled drug release

Jingquan Liu et al.

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Novel Thermosensitive Hydrogel Composites Based on Poly(D,L-lactide-co-glycolide) Nanoparticles Embedded in Poly(N-isopropyl acrylamide) with Sustained Drug-Release Behavior

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Pharmacologically active microcarriers associated with thermosensitive hydrogel as a growth factor releasing biomimetic 3D scaffold for cardiac tissue-engineering

Jean-Pierre Karam et al.

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Functionalized nanoscale graphene oxide for high efficient drug delivery of cisplatin

Lingyang Tian et al.

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Multi-arm PEG/Silica Hydrogel for Sustained Ocular Drug Delivery

Changhai Lu et al.

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Preparation and investigation of the physical and chemical properties of clay-based polyacrylamide/Cr (III) hydrogels as a water shut-off agent in oil reservoirs

Farhad Salimi et al.

KOREAN JOURNAL OF CHEMICAL ENGINEERING (2014)

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Double network self-healing graphene hydrogel by two step method for anticancer drug delivery

P. Chen et al.

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Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery

Vladimir P. Torchilin

NATURE REVIEWS DRUG DISCOVERY (2014)

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Collagen-based hydrogel films as drug-delivery devices with antimicrobial properties

Mehtap Sahiner et al.

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Investigation of Mechanical Properties, Antibacterial Features, and Water Vapor Permeability of Polyvinyl Alcohol Thin Films Reinforced by Glutaraldehyde and Multiwalled Carbon Nanotube

Seyed Mohammad Mahdi Dadfar et al.

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Designing unconventional Fmoc-peptide-based biomaterials: structure and related properties

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A magnetic nanogel based on O-carboxymethylchitosan for antitumor drug delivery: synthesis, characterization and in vitro drug release

Carla Albetina Demarchi et al.

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Small-molecule-hosting nanocomposite films with multiple bacteria-triggered responses

Svetlana Pavlukhina et al.

NPG ASIA MATERIALS (2014)

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Graphene-Based Electroresponsive Scaffolds as Polymeric Implants for On-Demand Drug Delivery

Ania Servant et al.

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Injectable and biodegradable thermosensitive hydrogels loaded with PHBHHx nanoparticles for the sustained and controlled release of insulin

Q. Peng et al.

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Agarose Hydrogels Embedded with pH-Responsive Diblock Copolymer Micelles for Triggered Release of Substances

Naixiong Jin et al.

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The spatiotemporal control of erosion and molecular release from micropatterned poly(ethylene glycol)-based hydrogel

Nihan Yonet-Tanyeri et al.

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A biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing

ChangYang Gong et al.

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Development of CMC hydrogels loaded with silver nano-particles for medical applications

Ali Hebeish et al.

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Thermal-responsive self-healing hydrogel based on hydrophobically modified chitosan and vesicle

Xiang Hao et al.

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Tunable hydrogel-Nanoparticles release system for sustained combination therapies in the spinal cord

Filippo Rossi et al.

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Intra-articular delivery of liposomal celecoxib-hyaluronate combination for the treatment of osteoarthritis in rabbit model

Ji Dong et al.

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A novel biocompatible magnetic iron oxide nanoparticles/hydrogel based on poly (acrylic acid) grafted onto starch for controlled drug release

Ghasem Rezanejade Bardajee et al.

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Delivery Systems and Local Administration Routes for Therapeutic siRNA

Fabiana Testa Moura de Carvalho Vicentini et al.

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Preparation of chitosan/mesoporous silica nanoparticle composite hydrogels for sustained co-delivery of biomacromolecules and small chemical drugs

Min Zhu et al.

SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS (2013)

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Hybrid Dendrimer Hydrogel/PLGA Nanoparticle Platform Sustains Drug Delivery for One Week and Antiglaucoma Effects for Four Days Following One-Time Topical Administration

Hu Yang et al.

ACS NANO (2012)

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Polymer nanogels: A versatile nanoscopic drug delivery platform

Reuben T. Chacko et al.

ADVANCED DRUG DELIVERY REVIEWS (2012)

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Development of a Hybrid Dextrin Hydrogel Encapsulating Dextrin Nanogel As Protein Delivery System

Maria Molinos et al.

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Nanostructured PEG-based hydrogels with tunable physical properties for gene delivery to human mesenchymal stem cells

Yan Li et al.

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Controlled drug delivery through a novel PEG hydrogel encapsulated silica aerogel system

Seda Giray et al.

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Hydrogel of Ketoconazole and PAMAM Dendrimers: Formulation and Antifungal Activity

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Functional acrylic acid as stabilizer for synthesis of smart hydrogel particles containing a magnetic Fe3O4 core

Feng-Yi Chou et al.

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A Hybrid Hydrogel Biomaterial by Nanogel Engineering: Bottom-Up Design with Nanogel and Liposome Building Blocks to Develop a Multidrug Delivery System

Yurina Sekine et al.

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Hybrid Magnetic Hydrogel: A Potential System for Controlled Drug Delivery by Means of Alternating Magnetic Fields

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pH-Responsive Hydrogel/Liposome Soft Nanocomposites For Tuning Drug Release

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Injectable Microgel-Hydrogel Composites for Prolonged Small-Molecule Drug Delivery

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Evaluation of blood compatibility and drug release studies of gelatin based magnetic hydrogel nanocomposites

N. Narayana Reddy et al.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2011)

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Bioadhesive film formed from a novel organic-inorganic hybrid gel for transdermal drug delivery system

Ruiwei Guo et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2011)

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Magnetic and Electric Responsive Hydrogel-Magnetic Nanocomposites for Drug-Delivery Application

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Sustained release of VEGF from PLGA nanoparticles embedded thermo-sensitive hydrogel in full-thickness porcine bladder acellular matrix

Hongquan Geng et al.

NANOSCALE RESEARCH LETTERS (2011)

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Chitosan-silicate biocomposites to be used in modified drug release of 5-aminosalicylic acid (5-ASA)

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APPLIED CLAY SCIENCE (2010)

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Synthesis and Characterization of Photocurable Polyamidoamine Dendrimer Hydrogels as a Versatile Platform for Tissue Engineering and Drug Delivery

Pooja N. Desai et al.

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Hybrid hyaluronan hydrogel encapsulating nanogel as a protein nanocarrier: New system for sustained delivery of protein with a chaperone-like function

Tai Hirakura et al.

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Enhanced biological stability of collagen with incorporation of PAMAM dendrimer

Shaoping Zhong et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2009)

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Calcein Release from Polymeric Vesicles in Blood Plasma and PVA Hydrogel

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PHARMACEUTICAL RESEARCH (2009)

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Biopolymer-based microgels/nanogels for drug delivery applications

Jung Kwon Oh et al.

PROGRESS IN POLYMER SCIENCE (2009)

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Advanced nanogel engineering for drug delivery

Koen Raemdonck et al.

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Magnetic hydrogel nanocomposites for remote controlled pulsatile drug release

Nitin S. Satarkar et al.

JOURNAL OF CONTROLLED RELEASE (2008)

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Hydrogels in drug delivery: Progress and challenges

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PVA-clay nanocomposite hydrogels for wound dressing

Mehrdad Kokabi et al.

EUROPEAN POLYMER JOURNAL (2007)

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Hydrogel networks as nanoreactors: A novel approach to silver nanoparticles for antibacterial applications

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Microgel, nanogel and hydrogel-hydrogel semi-IPN composites for biomedical applications: synthesis and characterization

Nurettin Sahiner et al.

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Nanosized cationic hydrogels for drug delivery: preparation, properties and interactions with cells

SV Vinogradov et al.

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