4.7 Article

A physiologically based pharmacokinetic and pharmacodynamic model for disposition of FF-10832

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Summary: The study characterized the stability, tumor targeting, and payload release of liposome-encapsulated gemcitabine, FF-10832, in mouse models of pancreatic cancer. Results showed that FF-10832 had superior pharmacokinetic properties and better antitumor activity and tolerability compared to unencapsulated gemcitabine. This suggests that FF-10832 is a promising candidate for the treatment of pancreatic cancer.

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