☆ 4.6 Review

Epigenetic modifications: Critical participants of the PD-L1 regulatory mechanism in solid tumors (Review)

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Histone deacetylase 2 knockout suppresses immune escape of triple-negative breast cancer cells via downregulating PD-L1 expression

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hsa_circ_0003222 accelerates stemness and progression of non-small cell lung cancer by sponging miR-527

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LncRNA HCG18 suppresses CD8+ T cells to confer resistance to cetuximab in colorectal cancer via miR-20b-5p/PD-L1 axis

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KDM1A Promotes Immunosuppression in Hepatocellular Carcinoma by Regulating PD-L1 through Demethylating MEF2D

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Pulmonary Aerosol Delivery of Let-7b microRNA Confers a Striking Inhibitory Effect on Lung Carcinogenesis through Targeting the Tumor Immune Microenvironment

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Targeting Histone Modifications in Breast Cancer: A Precise Weapon on the Way

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PRMT5 disruption drives antitumor immunity in cervical cancer by reprogramming T cell-mediated response and regulating PD-L1 expression

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Article Medicine, Research & Experimental

Protective effect of hsa-miR-570-3p targeting CD274 on triple negative breast cancer by blocking PI3K/AKT/mTOR signaling pathway

Li-Li Wang et al.

KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2020)

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BRCA1 Promoter Hypermethylation is Associated with Good Prognosis and Chemosensitivity in Triple-Negative Breast Cancer

William Jacot et al.

CANCERS (2020)

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HDAC10 Is Positively Associated With PD-L1 Expression and Poor Prognosis in Patients With NSCLC

Xiaomei Liu et al.

FRONTIERS IN ONCOLOGY (2020)

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p300/CBP inhibition enhances the efficacy of programmed death-ligand 1 blockade treatment in prostate cancer

Jinghui Liu et al.

ONCOGENE (2020)

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LncRNA GATA3-AS1 facilitates tumour progression and immune escape in triple-negative breast cancer through destabilization of GATA3 but stabilization of PD-L1

Ming Zhang et al.

CELL PROLIFERATION (2020)

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A Comprehensive Review of Cancer MicroRNA Therapeutic Delivery Strategies

Alexis Forterre et al.

CANCERS (2020)

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Endoplasmic reticulum stress-induced exosomal miR-27a-3p promotes immune escape in breast cancer via regulating PD-L1 expression in macrophages

Xiaoli Yao et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Resistance Mechanisms of Anti-PD1/PDL1 Therapy in Solid Tumors

Qingyang Lei et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Epigenetic Mechanisms of Resistance to Immune Checkpoint Inhibitors

Alexandre Perrier et al.

BIOMOLECULES (2020)

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Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus

Marco Mineo et al.

MOLECULAR CELL (2020)

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The novel reversible LSD1 inhibitor SP-2577 promotes anti-tumor immunity in SWItch/Sucrose-NonFermentable (SWI/SNF) complex mutated ovarian cancer

Raffaella Soldi et al.

PLOS ONE (2020)

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Circular RNA circ-CPA4/let-7 miRNA/PD-L1 axis regulates cell growth, stemness, drug resistance and immune evasion in non-small cell lung cancer (NSCLC)

Weijun Hong et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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MicroRNA-200b is a potential biomarker of the expression ofPD-L1in patients with lung cancer

Seigo Katakura et al.

THORACIC CANCER (2020)

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Cancer-Associated Fibroblasts-Derived Exosomes Suppress Immune Cell Function in Breast Cancer via the miR-92/PD-L1 Pathway

Dongwei Dou et al.

FRONTIERS IN IMMUNOLOGY (2020)

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A Lymphocyte MicroRNA Signature as Predictive Biomarker of Immunotherapy Response and Plasma PD-1/PD-L1 Expression Levels in Patients with Metastatic Renal Cell Carcinoma: Pointing towards Epigenetic Reprogramming

Lorena Incorvaia et al.

CANCERS (2020)

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Article Cell Biology

Exosomal miRNA-16-5p Derived From M1 Macrophages Enhances T Cell-Dependent Immune Response by Regulating PD-L1 in Gastric Cancer

Zhengtian Li et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Epigenetic regulation of immune checkpoints and T cell exhaustion markers in tumor-infiltrating T cells of colorectal cancer patients

Varun Sasidharan Nair et al.

EPIGENOMICS (2020)

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Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression

Thomas J. Rogers et al.

MOLECULAR CANCER RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Inhibition of histone lysine-specific demethylase 1 elicits breast tumor immunity and enhances antitumor efficacy of immune checkpoint blockade

Ye Qin et al.

ONCOGENE (2019)

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miR3609 sensitizes breast cancer cells to adriamycin by blocking the programmed death-ligand 1 immune checkpoint

Duolu Li et al.

EXPERIMENTAL CELL RESEARCH (2019)

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Overexpressed histone acetyltransferase 1 regulates cancer immunity by increasing programmed death-ligand 1 expression in pancreatic cancer

Ping Fan et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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miRNA-148a-3p Regulates Immunosuppression in DNA Mismatch Repair-Deficient Colorectal Cancer by Targeting PD-L1

Mai Ashizawa et al.

MOLECULAR CANCER RESEARCH (2019)

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HDAC3 Inhibition Upregulates PD-L1 Expression in B-Cell Lymphomas and Augments the Efficacy of Anti-PD-L1 Therapy

Siyu Deng et al.

MOLECULAR CANCER THERAPEUTICS (2019)

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Navigating metabolic pathways to enhance antitumour immunity and immunotherapy

Xiaoyun Li et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2019)

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Clinicopathological correlation of ARID1A status with HDAC6 and its related factors in ovarian clear cell carcinoma

Mitsutake Yano et al.

SCIENTIFIC REPORTS (2019)

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PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone Modifications

Pramod Darvin et al.

JOURNAL OF ONCOLOGY (2019)

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CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer

Laura M. McLane et al.

Annual Review of Immunology (2019)

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Efficacy and Safety of Pembrolizumab in Previously Treated Advanced Cervical Cancer: Results From the Phase II KEYNOTE-158 Study

Hyun Cheol Chung et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

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Targeting DNA Methylation and EZH2 Activity to Overcome Melanoma Resistance to Immunotherapy

Abdullah Al Emran et al.

TRENDS IN IMMUNOLOGY (2019)

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EZH2 regulates PD-L1 expression via HIF-1α in non-small cell lung cancer cells

Yuetao Zhao et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Noncoding RNAs in cancer therapy resistance and targeted drug development

Wen-Tao Wang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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The RNA-binding protein RBM3 promotes cell proliferation in hepatocellular carcinoma by regulating circular RNA SCD-circRNA 2 production

Wei Dong et al.

EBIOMEDICINE (2019)

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Epigenetic Priming in Immunodeficiencies

Jorge Martinez-Cano et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

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Long Noncoding RNA MIR17HG Promotes Colorectal Cancer Progression via miR-17-5p

Jie Xu et al.

CANCER RESEARCH (2019)

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Long Non-Coding RNAs as Epigenetic Regulators in Cancer

Asma Vafadar et al.

CURRENT PHARMACEUTICAL DESIGN (2019)

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Long non-coding RNA HOTTIP enhances IL-6 expression to potentiate immune escape of ovarian cancer cells by upregulating the expression of PD-L1 in neutrophils

Anquan Shang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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Immune checkpoint inhibitors of PD-L1 as cancer therapeutics

Akintunde Akinleye et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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The Role Of PD-1/PD-L1 Axis In Treg Development And Function: Implications For Cancer Immunotherapy

Jiajing Cai et al.

ONCOTARGETS AND THERAPY (2019)

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Selective HDAC6 inhibitors improve anti-PD-1 immune checkpoint blockade therapy by decreasing the anti-inflammatory phenotype of macrophages and down-regulation of immunosuppressive proteins in tumor cells (vol 9, 6136, 2019)

Tessa Knox et al.

SCIENTIFIC REPORTS (2019)

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Diuron exposure and Akt overexpression promote glioma formation through DNA hypomethylation

Josephine Briand et al.

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MPT0G612, a Novel HDAC6 Inhibitor, Induces Apoptosis and Suppresses IFN-γ-Induced Programmed Death-Ligand 1 in Human Colorectal Carcinoma Cells

Mei-Chuan Chen et al.

CANCERS (2019)

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Role of the HDAC6/STAT3 pathway in regulating PD-L1 expression in osteosarcoma cell lines

Ajimu Keremu et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2019)

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Role of miRNAs in immune responses and immunotherapy in cancer

Maria Angelica Cortez et al.

GENES CHROMOSOMES & CANCER (2019)

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Cancer immunoediting and resistance to T cell-based immunotherapy

Jake S. O'Donnell et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2019)

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Microenvironmental oxygen pressure orchestrates an anti- and pro-tumoral γδ T cell equilibrium via tumor-derived exosomes

Ling Li et al.

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HDAC3 modulates cancer immunity via increasing PD-L1 expression in pancreatic cancer

Guofu Hu et al.

PANCREATOLOGY (2019)

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Immune checkpoint blockade resistance-related B2M hotspot mutations in microsatellite-unstable colorectal carcinoma

Su Yeon Yeon et al.

PATHOLOGY RESEARCH AND PRACTICE (2019)

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LIN28/let-7/PD-L1 Pathway as a Target for Cancer Immunotherapy

Yanlian Chen et al.

CANCER IMMUNOLOGY RESEARCH (2019)

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Specific zinc finger-induced methylation of PD-L1 promoter inhibits its expression

Xue Li et al.

FEBS OPEN BIO (2019)

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DNA methylation of immune checkpoints in the peripheral blood of breast and colorectal cancer patients

Asma A. Elashi et al.

ONCOIMMUNOLOGY (2019)

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Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression (vol 19, pg 1189, 2017)

Angel Garcia-Diaz et al.

CELL REPORTS (2019)

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MiR-140 Expression Regulates Cell Proliferation and Targets PD-L1 in NSCLC

Wei-Bin Xie et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

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Regulation and Function of the PD-L1 Checkpoint

Chong Sun et al.

IMMUNITY (2018)

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Differences in histological features and PD-L1 expression between sporadic microsatellite instability and Lynch-syndrome-associated disease in Japanese patients with colorectal cancer

Rin Yamada et al.

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY (2018)

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The Nefarious Nexus of Noncoding RNAs in Cancer

Eleni Anastasiadou et al.

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The miR-3127-5p/p-STAT3 axis up-regulates PD-L1 inducing chemoresistance in non-small-cell lung cancer

Dongfang Tang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018)

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Cooperativity of HOXA5 and STAT3 Is Critical for HDAC8 Inhibition-Mediated Transcriptional Activation of PD-L1 in Human Melanoma Cells

Yu Fang Wang et al.

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The Key Role of Epigenetics in Human Disease Prevention and Mitigation

Andrew P. Feinberg

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Decitibine improve the efficiency of anti-PD-1 therapy via activating the response to IFN/PD-L1 signal of lung cancer cells

Qi Lai et al.

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Chemotherapy induces enrichment of CD47+/CD73+/PDL1+ immune evasive triple-negative breast cancer cells

Debangshu Samanta et al.

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Cancer immunotherapy using checkpoint blockade

Antoni Ribas et al.

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The IDH1 Mutation-Induced Oncometabolite, 2-Hydroxyglutarate, May Affect DNA Methylation and Expression of PD-L1 in Gliomas

Luyan Mu et al.

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PD-L1 expression is regulated by both DNA methylation and NF-kappa B during EMT signaling in non-small cell lung carcinoma

A. Asgarova et al.

ONCOIMMUNOLOGY (2018)

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Lung Cancer Therapy Targeting Histone Methylation: Opportunities and Challenges

Yuchen Chen et al.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2018)

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Let-7 microRNA as a potential therapeutic target with implications for immunotherapy

Maud-Emmanuelle Gilles et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2018)

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The class I/IV HDAC inhibitor mocetinostat increases tumor antigen presentation, decreases immune suppressive cell types and augments checkpoint inhibitor therapy

David Briere et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2018)

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miR-195/miR-497 Regulate CD274 Expression of Immune Regulatory Ligands in Triple-Negative Breast Cancer

Lianzhou Yang et al.

JOURNAL OF BREAST CANCER (2018)

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Marked Global DNA Hypomethylation Is Associated with Constitutive PD-L1 Expression in Melanoma

Aniruddha Chatterjee et al.

ISCIENCE (2018)

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MicroRNA-targeted therapeutics for lung cancer treatment

Jing Xue et al.

EXPERT OPINION ON DRUG DISCOVERY (2017)

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MicroRNAs Associated with Von Hippel-Lindau Pathway in Renal Cell Carcinoma: A Comprehensive Review

Lisa-Maria Schanza et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Clinical applications of PD-L1 bioassays for cancer immunotherapy

Delong Liu et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2017)

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The MLL1-H3K4me3 Axis-Mediated PD-L1 Expression and Pancreatic Cancer Immune Evasion

Chunwan Lu et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

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Targeting the PD-L1/DNMT1 axis in acquired resistance to sorafenib in human hepatocellular carcinoma

Jianhua Liu et al.

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Histone Acetyltransferase 1 Promotes Cell Proliferation and Induces Cisplatin Resistance in Hepatocellular Carcinoma

Xin Jin et al.

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Resistance to checkpoint blockade therapy through inactivation of antigen presentation

Moshe Sade-Feldman et al.

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PD-L1 promoter methylation mediates the resistance response to anti-PD-1 therapy in NSCLC patients with EGFR-TKI resistance

Yan Zhang et al.

ONCOTARGET (2017)

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The miR-25-93-106b cluster regulates tumor metastasis and immune evasion via modulation of CXCL12 and PD-L1

Michele Cioffi et al.

ONCOTARGET (2017)

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The Histone Methyltransferase Ezh2 Controls Mechanisms of Adaptive Resistance to Tumor Immunotherapy

Daniel Zingg et al.

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Histone deacetylase inhibitors potentiate photodynamic therapy in colon cancer cells marked by chromatin-mediated epigenetic regulation of CDKN1A

Andrea Halaburkova et al.

CLINICAL EPIGENETICS (2017)

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The MLL1-H3K4me3 Axis-Mediated PD-L1 Expression and Pancreatic Cancer Immune Evasion

Chunwan Lu et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

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Resistance to PD1/PDL1 checkpoint inhibition

Jake S. O'Donnell et al.

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Programmed Death Ligand-1 (PD-L1) Expression in the Programmed Death Receptor-1 (PD-1)/PD-L1 Blockade A Key Player Against Various Cancers

Jian Guan et al.

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE (2017)

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Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy

Padmanee Sharma et al.

CELL (2017)

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Regulation of PD-L1: a novel role of pro-survival signalling in cancer

J. Chen et al.

ANNALS OF ONCOLOGY (2016)

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The prognostic value of the miR-200 family in ovarian cancer: a meta-analysis

Can Shi et al.

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA (2016)

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A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to Restrain Inflammation

Maninjay K. Atianand et al.

CELL (2016)

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Essential role of HDAC6 in the regulation of PD-L1 in melanoma

M. Lienlaf et al.

MOLECULAR ONCOLOGY (2016)

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Targeting EZH2 in cancer

Kimberly H. Kim et al.

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Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

Kristen E. Pauken et al.

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HDACs and HDAC Inhibitors in Cancer Development and Therapy

Yixuan Li et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)

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Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

Suzanne L. Topalian et al.

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Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy

Dongjun Peng et al.

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Short- and long-term effects of chromosome mis-segregation and aneuploidy

Stefano Santaguida et al.

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HDAC Inhibition Upregulates PD-1 Ligands in Melanoma and Augments Immunotherapy with PD-1 Blockade

David M. Woods et al.

CANCER IMMUNOLOGY RESEARCH (2015)

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Histone Modifications, Modifiers and Readers in Melanoma Resistance to Targeted and Immune Therapy

Stuart J. Gallagher et al.

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Post-Translational Modifications of Histones That Influence Nucleosome Dynamics

Gregory D. Bowman et al.

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The role of regulatory T cells in cancer immunology

Theresa L. Whiteside

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Treatment of resistant metastatic melanoma using sequential epigenetic therapy (decitabine and panobinostat) combined with chemotherapy (temozolomide)

Chang Xia et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2014)

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Impact of microRNAs in Resistance to Chemotherapy and Novel Targeted Agents in Non-Small Cell Lung Cancer

Christian Rolfo et al.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2014)

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The cancer antigenome

Bianca Heemskerk et al.

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Epithelial-mesenchymal transition - activating transcription factors - multifunctional regulators in cancer

Minal Garg

World Journal of Stem Cells (2013)

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A frequent somatic mutation in CD274 3'-UTR leads to protein over-expression in gastric cancer by disrupting miR-570 binding

Weipeng Wang et al.

HUMAN MUTATION (2012)

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Histone methylation: a dynamic mark in health, disease and inheritance

Eric L. Greer et al.

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Cancer immunotherapy comes of age

Ira Mellman et al.

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Exosomes: Extracellular organelles important in intercellular communication

Suresh Mathivanan et al.

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Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis

Jesper V. Olsen et al.

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Histone H3 phosphorylation Universal code or lineage specific dialects?

Heriberto Cerutti et al.

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Current status of epigenetic treatment in myelodysplastic syndromes

Andrea Kuendgen et al.

ANNALS OF HEMATOLOGY (2008)

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High-resolution profiling of histone methylations in the human genome

Artern Barski et al.

CELL (2007)

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Arginine methylation: An emerging regulator of protein function

MT Bedford et al.

MOLECULAR CELL (2005)

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Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

HD Dong et al.

NATURE MEDICINE (2002)

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Effects of acetylation of histone H4 at lysines 8 and 16 on activity of the Hat1 histone acetyltransferase

AM Makowski et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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