Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 18, Pages -Publisher
MDPI
DOI: 10.3390/ijms231810735
Keywords
hypochlorous acid HOCl; halogenative stress; myeloperoxidase MPO; pathologies
Funding
- project Agencia Canaria de Investigacion, Innovacion y Sociedad de la Informacion (ACIISI) del Gobierno de Canarias [ProID2020010134]
- Spanish Ministry of Economy and Competitiveness [PID2019-105838RB-C31]
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This review discusses the formation of hypochlorous acid HOCl and the role of reactive chlorinated species (RCS) catalyzed by the enzyme myeloperoxidase MPO. The reactions of RCS with various organic molecules and the chemical mechanisms of chlorinated derivatives formation are described. The review also examines the presence of RCS in various pathologies.
This review discusses the formation of hypochlorous acid HOCl and the role of reactive chlorinated species (RCS), which are catalysed by the enzyme myeloperoxidase MPO, mainly located in leukocytes and which in turn contribute to cellular oxidative stress. The reactions of RCS with various organic molecules such as amines, amino acids, proteins, lipids, carbohydrates, nucleic acids, and DNA are described, and an attempt is made to explain the chemical mechanisms of the formation of the various chlorinated derivatives and the data available so far on the effects of MPO, RCS and halogenative stress. Their presence in numerous pathologies such as atherosclerosis, arthritis, neurological and renal diseases, diabetes, and obesity is reviewed and were found to be a feature of debilitating diseases.
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