4.7 Article

Genetic Disruption of Guanylyl Cyclase/Natriuretic Peptide Receptor-A Triggers Differential Cardiac Fibrosis and Disorders in Male and Female Mutant Mice: Role of TGF-β1/SMAD Signaling Pathway

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Review Physiology

Molecular Signaling Mechanisms and Function of Natriuretic Peptide Receptor-A in the Pathophysiology of Cardiovascular Homeostasis

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Summary: The discovery of atrial, brain, and C-type natriuretic peptides (ANP, BNP, and CNP) and their receptors, as well as the involvement of guanylyl cyclase/natriuretic peptide receptor-A (GC-A/NPRA) in their regulatory actions, has advanced our understanding of hypertension and cardiovascular homeostasis control. ANP and BNP act as potent hypotensive hormones, reducing blood pressure and protecting against cardiovascular diseases through cGMP production. The therapeutic potential of natriuretic peptides (NPs) and their receptors in treating and preventing cardiovascular diseases has yet to be fully explored through further research.

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