Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 19, Pages -Publisher
MDPI
DOI: 10.3390/ijms231911755
Keywords
breast cancer; HOTAIR; miR-203; CAV1; ceRNA; invasion; migration
Funding
- National Natural Science Foundation of China [31860317, 32160169]
- Key Project of Jiangxi Provincial Natural Science Foundation [20212ACB206040]
- National Natural Science Foundation of Jiangxi province [20202BAB206056]
- Key Laboratory of Functional and Clinical Translational Medicine, Fujian Province University [XMMC-FCTM202103]
- College Students Innovation Training Program o Nanchang University [202110403005, S202210403004]
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This study reveals the role of the HOTAIR/miR-203/CAV1 axis in breast cancer through the use of bioinformatics tools and basic experiments, expanding the role network of HOTAIR as a ceRNA.
In recent years, malignant breast cancer metastasis has caused a great increase in mortality. Research on the genetic and molecular mechanisms of malignant breast cancer has continued to deepen, and targeted therapy has become the general trend. Among them, competing endogenous RNA (ceRNA)-related molecules have received much attention. Homeobox transcript antisense RNA (HOTAIR) has been reported to function extensively as a ceRNA in breast cancer. Notably, miR-203 and Caveolin 1 (CAV1) have also been found to play a role in breast cancer. However, the relationship between the three remains unclear. In this study, we present a new mechanic through bioinformatics tool and basic experiments: the HOTAIR/miR-203/CAV1 axis, which complemented the role network of HOTAIR as a ceRNA, thus, it will provide a novel potential idea for breast cancer research and therapy.
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