4.7 Article

Orlistat Mitigates Oxidative Stress-Linked Myocardial Damage via NF-κβ- and Caspase-Dependent Activities in Obese Rats

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Anti-Atherogenic Effects of Orlistat on Obesity-Induced Vascular Oxidative Stress Rat Model

Zaidatul Akmal Othman et al.

Summary: The study investigated the anti-atherosclerotic effect of orlistat on obesity-induced vascular oxidative stress in male rats. Orlistat treatment significantly improved lipid profiles, increased antioxidant enzymes, and decreased pro-inflammatory markers expressions, suggesting its therapeutic effect in attenuating the progression of atherosclerosis in obesity.

ANTIOXIDANTS (2021)

Article Medicine, Research & Experimental

Captopril downregulates expression of Bax/cytochrome C/caspase-3 apoptotic pathway, reduces inflammation, and oxidative stress in cisplatin-induced acute hepatic injury

Basma G. Eid et al.

Summary: Pre-treatment with Cap effectively protects against Cis-induced liver toxicity by reducing inflammation and apoptosis, and enhancing the antioxidant system.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Veterinary Sciences

Protective and Therapeutic Effects of Orlistat on Metabolic Syndrome and Oxidative Stress in High-Fat Diet-Induced Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) in Rats: Role on Nrf2 Activation

Zaida Zakaria et al.

Summary: This study investigated the protective and therapeutic effects of orlistat on high-fat diet-induced MAFLD in rats by activating the Nrf2 signaling pathway to improve metabolic syndrome and oxidative stress parameters. The results showed that orlistat significantly improved obesity index, liver enzymes, lipid levels, insulin resistance, NASH, and oxidative stress in HFD rats.

VETERINARY SCIENCES (2021)

Article Cardiac & Cardiovascular Systems

Anti-fibrotic Actions of Roselle Extract in Rat Model of Myocardial Infarction

Shafreena Shaukat Ali et al.

CARDIOVASCULAR TOXICOLOGY (2019)

Review Medicine, General & Internal

Complications of obesity

D. Kinlen et al.

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE (2018)

Article Biochemistry & Molecular Biology

Long-term intake of a high-protein diet increases liver triacylglycerol deposition pathways and hepatic signs of injury in rats

Ruben Diaz-Rua et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2017)

Review Medicine, General & Internal

The role of oxidative stress on the pathophysiology of metabolic syndrome

Fabiane Valentini Francisqueti et al.

REVISTA DA ASSOCIACAO MEDICA BRASILEIRA (2017)

Article Endocrinology & Metabolism

High-fat diet-induced obesity Rat model: a comparison between Wistar and Sprague-Dawley Rat

Claudia Marques et al.

ADIPOCYTE (2016)

Article Biochemistry & Molecular Biology

Cardiac fatty acid oxidation in heart failure associated with obesity and diabetes

Arata Fukushima et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2016)

Review Cardiac & Cardiovascular Systems

Update on Obesity and Obesity Paradox in Heart Failure

Carl J. Lavie et al.

PROGRESS IN CARDIOVASCULAR DISEASES (2016)

Article Pharmacology & Pharmacy

Effect of orlistat alone or in combination with Garcinia cambogia on visceral adiposity index in obese patients

Hayder M. Al-Kuraishy et al.

JOURNAL OF INTERCULTURAL ETHNOPHARMACOLOGY (2016)

Article Pharmacology & Pharmacy

Naringenin protects cardiac hypercholesterolemia-induced oxidative stress and subsequent necroptosis in rats

Yassine Chtourou et al.

PHARMACOLOGICAL REPORTS (2015)

Review Endocrinology & Metabolism

Mechanism and clinical evidence of lipocalin-2 and adipocyte fatty acid-binding protein linking obesity and atherosclerosis

Guangyu Wu et al.

DIABETES-METABOLISM RESEARCH AND REVIEWS (2014)

Article Nutrition & Dietetics

Bioelectrical impedance analysis and anthropometry for the determination of body composition in rats: effects of high-fat and high-sucrose diets

Larissa Rodrigues Neto Angeloco et al.

REVISTA DE NUTRICAO-BRAZILIAN JOURNAL OF NUTRITION (2012)

Review Biochemistry & Molecular Biology

Inflammation, Oxidative Stress, and Obesity

Alba Fernandez-Sanchez et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2011)

Review Biochemistry & Molecular Biology

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

Truyen Nguyen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Endocrinology & Metabolism

Cardiac Fas receptor-dependent apoptotic pathway in obese Zucker rats

Shin-Da Lee et al.

OBESITY (2007)