4.7 Article

Coagulation Factor XIIIa and Activated Protein C Activate Platelets via GPVI and PAR1

Related references

Note: Only part of the references are listed.
Article Hematology

Effects of Platelet Agonists and Priming on the Formation of Platelet Populations

Alicia Veninga et al.

Summary: Platelets from healthy donors exhibit heterogeneity in response to agonists, with activation thresholds controlled by various bioactive molecules. Elevated levels of priming substances like adenosine and succinate have been associated with hypercoagulability in patients with ischaemic heart disease. An improved flow cytometry methodology was employed to analyze platelet populations following activation and priming, revealing distinct responses based on the type of agonist used. The study identified five platelet populations post-activation, each with different characteristics depending on the agonist utilized, highlighting the complex and dynamic nature of platelet activation.

THROMBOSIS AND HAEMOSTASIS (2022)

Article Hematology

Factor XIII is a newly identified binding partner for platelet collagen receptor GPVI-dimer-An interaction that may modulate fibrin crosslinking

Masaaki Moroi et al.

Summary: The study found that GPVI-dimer specifically binds to the A-subunit of FXIII, inhibiting the crosslinking of fibrin gamma-chains in clots catalyzed by FXIII, thus regulating clot formation.

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2022)

Review Hematology

Interplay between platelets and coagulation

Yaqiu Sang et al.

Summary: Haemostasis is a regulated physiological process involving interactions between endothelial cells, platelets, von Willebrand factor, and coagulation factors. Platelets and coagulation mutually influence each other to effectively stop bleeding by forming a platelet plug.

BLOOD REVIEWS (2021)

Article Hematology

Nonredundant Roles of Platelet Glycoprotein VI and Integrin αIIbβ3 in Fibrin-Mediated Microthrombus Formation

Gina Perrella et al.

Summary: The study revealed that fibrin fibers play a consolidating role in microthrombus formation through nonredundant signaling of platelet glycoprotein VI and integrin alpha IIb beta 3 via Syk and low-level Ca2+ rises, even in the absence of thrombin, leading to minimal thrombin generation.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2021)

Article Cardiac & Cardiovascular Systems

Diagnosis and Management of Patients With Myocardial Injury After Noncardiac Surgery: A Scientific Statement From the American Heart Association

Kurt Ruetzler et al.

Summary: Myocardial injury after noncardiac surgery is defined by elevated cardiac troponin levels, occurring in about 20% of patients, and independently associated with mortality. Monitoring is recommended for high-risk patients.

CIRCULATION (2021)

Article Cell Biology

Immobilized collagen prevents shedding and induces sustained GPVI clustering and signaling in platelets

Chiara Pallini et al.

Summary: The study demonstrates that GPVI remains clustered along immobilized collagen fibers for at least 3 hours, protecting against shedding and maintaining signaling and intracellular Ca2+ elevation. Syk is crucial for maintaining clustering of integrin alpha 2 beta 1, while GPVI clustering does not depend on Syk and Src kinases.

PLATELETS (2021)

Article Hematology

Pharmacological Blockade of Glycoprotein VI Promotes Thrombus Disaggregation in the Absence of Thrombin

Muhammad Usman Ahmed et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2020)

Article Multidisciplinary Sciences

Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia

Xiao-Yan Zhao et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Role of Platelet Glycoprotein VI and Tyrosine Kinase Syk in Thrombus Formation on Collagen-Like Surfaces

Natalie J. Jooss et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Multidisciplinary Sciences

PAR1 agonists stimulate APC-like endothelial cytoprotection and confer resistance to thromboinflammatory injury

Karen De Ceunynck et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Hematology

Integrating platelet and coagulation activation in fibrin clot formation

Frauke Swieringa et al.

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2018)

Article Medicine, General & Internal

Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease

J. W. Eikelboom et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Hematology

Fibrin activates GPVI in human and mouse platelets

Osama M. Alshehri et al.

BLOOD (2015)

Article Multidisciplinary Sciences

Effects of Exogenous Recombinant APC in Mouse Models of Ischemia Reperfusion Injury and of Atherosclerosis

Karin C. A. A. Wildhagen et al.

PLOS ONE (2014)

Article Multidisciplinary Sciences

Identification of platelet function defects by multi-parameter assessment of thrombus formation

Susanne M. de Witt et al.

NATURE COMMUNICATIONS (2014)

Article Cardiac & Cardiovascular Systems

Reduction of Stent Thrombosis in Patients With Acute Coronary Syndromes Treated With Rivaroxaban in ATLAS-ACS 2 TIMI 51

C. Michael Gibson et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2013)

Review Hematology

Platelet-based coagulation: different populations, different functions

J. W. M. Heemskerk et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2013)

Review Physiology

NEW FUNDAMENTALS IN HEMOSTASIS

Henri H. Versteeg et al.

PHYSIOLOGICAL REVIEWS (2013)

Review Hematology

The future of glycoprotein VI as an antithrombotic target

M. Zahid et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2012)

Article Biochemical Research Methods

Fiji: an open-source platform for biological-image analysis

Johannes Schindelin et al.

NATURE METHODS (2012)

Article Multidisciplinary Sciences

Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through β-arrestin and dishevelled-2 scaffolds

Unice J. K. Soh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Hematology

Identification of Coagulation Factor XI as a Ligand for Platelet Apolipoprotein E Receptor 2 (ApoER2)

Tara C. White-Adams et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2009)

Review Hematology

Platelet α-granules: Basic biology and clinical correlates

Price Blair et al.

BLOOD REVIEWS (2009)

Article Biochemistry & Molecular Biology

Identification of a binding site for glycoprotein Ibα in the Apple 3 domain of factor XI

FA Baglia et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Hematology

Human platelet glycoprotein VI function is antagonized by monoclonal anti body-derived Fab fragments

C Lecut et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2003)