Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 19, Pages -Publisher
MDPI
DOI: 10.3390/ijms231911444
Keywords
thyroid hormone receptors; RNA-seq; ChIP-seq; atlas; target genes
Funding
- European Union [825753]
- H2020 Societal Challenges Programme [825753] Funding Source: H2020 Societal Challenges Programme
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We have created a database that integrates RNA-seq and ChIP-seq data to better understand the target genes of thyroid hormone receptors in different cell types. This database serves as a resource for studying the mode of action of thyroid hormone and provides a user-friendly tool to access specific gene information and extract gene lists of interest.
We gathered available RNA-seq and ChIP-seq data in a single database to better characterize the target genes of thyroid hormone receptors in several cell types. This database can serve as a resource to analyze the mode of action of thyroid hormone (T3). Additionally, it is an easy-to-use and convenient tool to obtain information on specific genes regarding T3 regulation or to extract large gene lists of interest according to the users' criteria. Overall, this atlas is a unique compilation of recent sequencing data focusing on T3, its receptors, modes of action, targets and roles, which may benefit researchers within the field. A preliminary analysis indicates extensive variations in the repertoire of target genes where transcription is upregulated by chromatin-bound nuclear receptors. Although it has a major influence, chromatin accessibility is not the only parameter that determines the cellular selectivity of the hormonal response.
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