Characterization of the Molecular Alterations Induced by the Prolonged Exposure of Normal Colon Mucosa and Colon Cancer Cells to Low-Dose Bisphenol A

Article Environmental Sciences

Analyzing the synergistic adverse effects of BPA and its substitute, BHPF, on ulcerative colitis through comparative metabolomics

Feiying Yin et al.

Summary: The study revealed the synergistic adverse effects of bisphenol A (BPA) and its substitute fluorene-9-bisphenol (BHPF) on ulcerative colitis (UC), providing new insights into UC development through alterations in gut metabolism.

CHEMOSPHERE (2022)

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Article Cell Biology

DGKZ promotes TGFβ signaling pathway and metastasis in triple-negative breast cancer by suppressing lipid raft-dependent endocytosis of TGFβR2

Yuanyuan Zhao et al.

Summary: This study identified DGKZ as a potential prometastatic gene in breast cancer. It was found that high expression of DGKZ was correlated with tumor progression and poor prognosis. Mechanistic studies showed that DGKZ might regulate cell metastasis by promoting epithelial-mesenchymal transition via the TGF-β signaling pathway.

CELL DEATH & DISEASE (2022)

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Article Engineering, Environmental

Lipidomic biomarkers: Potential mediators of associations between urinary bisphenol A exposure and colorectal cancer

Xu Hong et al.

Summary: This study found a higher level of bisphenol A (BPA) in the urine of colorectal cancer (CRC) patients compared to controls, and a positive correlation between BPA and CRC biomarkers. Lipidomic screening revealed significant perturbation in the glycerophospholipid metabolism pathway, which contributed to the association between BPA exposure and CRC. These findings contribute to a better understanding of the etiology of CRC induced by environmental stressors.

JOURNAL OF HAZARDOUS MATERIALS (2022)

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Review Biochemistry & Molecular Biology

Obesity and Inflammation: Colorectal Cancer Engines

Lara J. Bou Malhab et al.

Summary: Obesity is associated with the development of colorectal cancer, and obese patients are more likely to suffer from chemotherapy overdosing. Defining molecular alterations and the role of the microenvironment can provide therapeutic choices for obesity-associated colorectal cancer. However, preventing obesity remains the best remedy.

CURRENT MOLECULAR PHARMACOLOGY (2022)

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Article Oncology

PITPNA-AS1/miR-98-5p to Mediate the Cisplatin Resistance of Gastric Cancer

Zhongling Ma et al.

Summary: This study found that the overexpression of lncRNA PITPNA-AS1 in gastric cancer is associated with poor survival. Inhibiting PITPNA-AS1 can inhibit cell growth and induce apoptotic cell death in gastric cancer cells. Furthermore, PITPNA-AS1 is elevated in cisplatin-resistant gastric cancer cells, and its inhibition can increase the sensitivity of gastric cancer cells to cisplatin treatment.

JOURNAL OF ONCOLOGY (2022)

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Article Oncology

Crosstalk between PI3K/Akt and Wnt/β-catenin pathways promote colorectal cancer progression regardless of mutational status

Cassio Dejair Fleming-de-Moraes et al.

Summary: The interaction between PI3K/Akt and Wnt/β-catenin pathways contributes to colorectal cancer progression, promoting cell migration and proliferation. Reversal of these events using a PI3K inhibitor offers potential targeted therapies for colorectal cancer patients.

CANCER BIOLOGY & THERAPY (2022)

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Article Cell Biology

WNK1 kinase signaling in metastasis and angiogenesis

Chia-Ying Hou et al.

Summary: With-no-lysine kinases (WNKs) are a type of serine/threonine protein kinases involved in ion homeostasis. WNK1, in particular, has been found to play crucial roles in cancer metastasis and angiogenesis. Targeting WNK1 could be a promising anti-cancer strategy.

CELLULAR SIGNALLING (2022)

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Article Endocrinology & Metabolism

Bisphenol A Promotes the Progression of Colon Cancer Through Dual-Targeting of NADPH Oxidase and Mitochondrial Electron-Transport Chain to Produce ROS and Activating HIF-1a/VEGF/PI3K/AKT Axis

Tianyi Xia et al.

Summary: This study investigates the effects of BPA on the migration and invasion of colon cancer cells. The results show that BPA exposure promotes cell migration and invasion through the excessive production of ROS and activation of the HIF-1 alpha/VEGF/PI3K/AKT axis. This study provides new insights into the carcinogenic effects of BPA on colon cancer and raises awareness of the environmental pollution and harm to human health caused by low-dose BPA.

FRONTIERS IN ENDOCRINOLOGY (2022)

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Article Medicine, General & Internal

Individual and Co-Expression Patterns of FAM83H and SCRIB at Diagnosis Are Associated with the Survival of Colorectal Carcinoma Patients

Tae Young Jeong et al.

Summary: This study found a significant association between FAM83H and SCRIB in colorectal carcinoma, suggesting their potential as prognostic markers and therapeutic targets for colorectal carcinomas.

DIAGNOSTICS (2022)

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Article Environmental Sciences

Bisphenol A exposure, interaction with genetic variants and colorectal cancer via mediating oxidative stress biomarkers

Yao Deng et al.

Summary: The study showed significant positive associations between BPA, 8-OHdG, and HNE-MA with colorectal cancer risk. The positive association of BPA with CRC risk might be partly mediated by oxidative stress HNE-MA. Additionally, BPA was found to interact with specific genetic variants to increase CRC risk.

ENVIRONMENTAL POLLUTION (2021)

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Article Food Science & Technology

Effects of bisphenol A on the proliferation, migration, and tumor growth of colon cancer cells: In vitro and in vivo evaluation with mechanistic insights related to ERK and 5-HT3

Ji Hae Jun et al.

Summary: BPA promotes proliferation and migration of colon cancer cells, decreases E-cadherin expression, and increases 5-HT3 receptor expression. In nude mouse xenograft models, tumor volume was significantly higher in the BPA-treated group.

FOOD AND CHEMICAL TOXICOLOGY (2021)

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Review Pharmacology & Pharmacy

Chronic Inflammation and Cancer: The Role of Endothelial Dysfunction and Vascular Inflammation

Lara J. Bou Malhab et al.

Summary: Long-lasting subclinical inflammation is linked to a variety of human diseases, particularly cancer. Healthy endothelial cells can inhibit tumor growth, while dysfunctional cells exposed to inflammatory environments may support cancer progression.

CURRENT PHARMACEUTICAL DESIGN (2021)

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Article Environmental Sciences

Bisphenol A induces ovarian cancer cell proliferation and metastasis through estrogen receptor-α pathways

Chen Sang et al.

Summary: The study found that BPA can stimulate proliferation and metastasis of ovarian cancer cells by upregulating various proteins through the ER alpha signaling pathway. These results provide new insights into the carcinogenic effects of BPA on ovarian cancer.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2021)

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Article Medicine, Research & Experimental

Environmental contaminant BPA causes intestinal damage by disrupting cellular repair and injury homeostasis in vivo and in vitro

Kai Wang et al.

Summary: BPA treatment results in increased intestinal permeability, activation of oxidative stress and inflammatory responses, inhibition of cell proliferation, induction of apoptosis, ultimately disrupting intestinal barrier function.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Cell Biology

Targeting Phosphatases and Kinases: How to Checkmate Cancer

Alice Turdo et al.

Summary: Metastatic disease is the leading cause of death in cancer patients globally. Cancer stem cells (CSCs) play a crucial role in therapy resistance, recurrence, and metastasis. Kinases and phosphatases are key regulators of cellular processes and their aberrant activation is a hallmark of cancer.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Medicine, General & Internal

Identification of Potential Bisphenol A (BPA) Exposure Biomarkers in Ovarian Cancer

Aeman Zahra et al.

Summary: This study analyzed a set of genes dysregulated in ovarian cancer cells in the presence of BPA to identify potential biomarkers. Through in silico analysis and immunohistochemistry validation, it was found that some genes could serve as biomarkers for ovarian cancer.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Oncology

PGC1α Loss Promotes Lung Cancer Metastasis through Epithelial-Mesenchymal Transition

Taek-In Oh et al.

Summary: Despite therapeutic advances, lung cancer remains one of the most dangerous cancers with a low 5-year survival rate due to metastasis and recurrence. The cooperation of TCF4-TWIST1 controlled by the PGC1 alpha-ID1 transcriptional axis is suggested to mediate EMT and lung cancer metastasis, presenting a potential diagnostic and therapeutic target. Studies show that PGC1 alpha and ID1 are downregulated in lung cancer and correlate with poor survival rates.

CANCERS (2021)

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Article Cell Biology

Identification of Stemness-Related Genes for Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma by Integrated Bioinformatics Analysis

Hongjun Guo et al.

Summary: This study identified key genes associated with metastasis of cervical squamous cell carcinoma (CESC) through methods like WGCNA, constructed a metastasis-specific regulation network, and discovered potential bioactive small molecule inhibitors. VIM, positively regulated by NR5A2, affected EMT signaling pathways in metastatic CESC, and naringenin was highlighted as a potential inhibitor for the treatment of metastatic CESC by suppressing cancer stemness.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Cell Biology

NR5A2 transcriptional activation by BRD4 promotes pancreatic cancer progression by upregulating GDF15

Feng Guo et al.

Summary: NR5A2 acts as a negative prognostic biomarker in pancreatic ductal adenocarcinoma (PDAC), being transcriptionally upregulated by BRD4 and promoting pancreatic cancer progression through inducing the transcription of GDF15.

CELL DEATH DISCOVERY (2021)

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Article Immunology

VMP1, a novel prognostic biomarker, contributes to glioma development by regulating autophagy

Wanzun Lin et al.

Summary: The study found that high expression of VMP1 in glioma patients is associated with faster disease progression and poorer prognosis. Depletion of VMP1 by CRISPR-Cas9 gene editing significantly inhibits cell proliferation, increases cell death, and induces cell cycle arrest. Knockout of VMP1 blocks autophagic flux and sensitizes glioma cells to radiotherapy and chemotherapy.

JOURNAL OF NEUROINFLAMMATION (2021)

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Article Medicine, Research & Experimental

CXCL12-mediated HOXB5 overexpression facilitates Colorectal Cancer metastasis through transactivating CXCR4 and ITGB3

Weibo Feng et al.

Summary: HOXB5 gene plays a crucial role in promoting colorectal cancer metastasis by transactivating metastatic related genes CXCR4 and ITGB3. Additionally, a positive feedback loop of CXCL12-HOXB5-CXCR4 has been identified to have an important role in colorectal cancer metastasis.

THERANOSTICS (2021)

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Article Oncology

Correlation between FAK and EGF-Induced EMT in Colorectal Cancer Cells

Kun Huang et al.

JOURNAL OF ONCOLOGY (2020)

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Article Biochemistry & Molecular Biology

Oncogenic Potential of Bisphenol A and Common Environmental Contaminants in Human Mammary Epithelial Cells

Vidhya A. Nair et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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FAM83H and SCRIB stabilize β-catenin and stimulate progression of gastric carcinoma

Usama Khamis Hussein et al.

Aging-US (2020)

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Inhibitor of Differentiation 1 (Id1) in Cancer and Cancer Therapy

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INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2020)

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Article Oncology

CXCL12/CXCR4 promotes inflammation-driven colorectal cancer progression through activation of RhoA signaling by sponging miR-133a-3p

Xinfeng Yu et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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Review Biochemistry & Molecular Biology

The Endocrine Disruptor Bisphenol A (BPA) Exerts a Wide Range of Effects in Carcinogenesis and Response to Therapy

Shirin A. Hafezi et al.

CURRENT MOLECULAR PHARMACOLOGY (2019)

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Bisphenol A induces apoptosis, oxidative stress and inflammatory response in colon and liver of mice in a mitochondria-dependent manner

Kai Wang et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Calponin 3 promotes invasion and drug resistance of colon cancer cells

Vidhya A. Nair et al.

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY (2019)

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MLK3 phosphorylation by ERK1/2 is required for oxidative stress-induced invasion of colorectal cancer cells

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Bisphenol A suppresses proliferation and induces apoptosis in colonic epithelial cells through mitochondrial and MAPK/AKT pathways

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Targeting an oncogenic kinase/phosphatase signaling network for cancer therapy

Xiao-Mei Qi et al.

Acta Pharmaceutica Sinica B (2018)

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Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

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CA-A CANCER JOURNAL FOR CLINICIANS (2018)

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Evaluation of Bisphenol A (BPA) Exposures on Prostate Stem Cell Homeostasis and Prostate Cancer Risk in the NCTR-Sprague-Dawley Rat: An NIEHS/FDA CLARITY-BPA Consortium Study

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Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells

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Low-Dose Bisphenol A Exposure: A Seemingly Instigating Carcinogenic Effect on Breast Cancer

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HMOX-1 inhibits TGF-β-induced epithelial-mesenchymal transition in the MCF-7 breast cancer cell line

Xiaofeng Zhu et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2017)

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FAM83 family oncogenes are broadly involved in human cancers: an integrative multi-omics approach

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Bisphenol A Exposure Promotes the Migration of NCM460 Cells Via Estrogen Receptor-Mediated Integrin β1/MMP-9 Pathway

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Casein kinase 1 is recruited to nuclear speckles by FAM83H and SON

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Downregulation of VMP1 confers aggressive properties to colorectal cancer

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Bisphenol A modulates colorectal cancer protein profile and promotes the metastasis via induction of epithelial to mesenchymal transitions

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Increased diacylglycerol kinase. expression in human metastatic colon cancer cells augments Rho GTPase activity and contributes to enhanced invasion

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Endocrine Disruptors and Breast Cancer Risk - Time to Consider the Environment

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Distinct Genetic and Epigenetic Signatures of Colorectal Cancers According to Ethnic Origin

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Genomic Instability and Carcinogenesis: An Update

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Characterization of the Molecular Alterations Induced by the Prolonged Exposure of Normal Colon Mucosa and Colon Cancer Cells to Low-Dose Bisphenol A

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