4.7 Review

Poisonous Piperidine Plants and the Biodiversity of Norditerpenoid Alkaloids for Leads in Drug Discovery: Experimental Aspects

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Norditerpenoid alkaloids from Aconitum and Delphinium: structural relevance in medicine, toxicology, and metabolism

Ashraf M. A. Qasem et al.

Summary: Norditerpenoid alkaloids (NDA) are complex natural products with important pharmacological activities. Research has shown that understanding the metabolism of NDA is crucial for their development as drugs.

NATURAL PRODUCT REPORTS (2022)

Article Chemistry, Multidisciplinary

Synthesis of [6-6-6] ABE tricyclic ring analogues of methyllycaconitine

Dan Xiao et al.

Summary: A new synthesis method has been developed to form the bridged [6-6-6] ABE tricyclic ring analogues of methyllycaconitine with C-1 oxygenated substituents, using efficient aza-annulation of beta-enamino ketone followed by a facile decarboxylation to form BE rings. Subsequent elaboration to form the A ring was achieved by a transannular acyl radical cyclization with concomitant equipment of the key C-1 oxygen functionality.

CHINESE CHEMICAL LETTERS (2021)

Article Chemistry, Multidisciplinary

Total Synthesis of Talatisamine

Daiki Kamakura et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Chemistry, Medicinal

Alkaloids from Delphinium aemulans

N. Ablajan et al.

CHEMISTRY OF NATURAL COMPOUNDS (2020)

Article Chemistry, Multidisciplinary

The 1α-hydroxy-A-rings of norditerpenoid alkaloids are twisted-boat conformers

Ziyu Zeng et al.

RSC ADVANCES (2020)

Article Chemistry, Medicinal

Nagarines A and B, two novel 8,15-seco diterpenoid alkaloids from Aconitum nagarum

Tianpeng Yin et al.

FITOTERAPIA (2019)

Article Agriculture, Dairy & Animal Science

Sex-dependent differences for larkspur (Delphinium barbeyi) toxicosis in yearling Angus cattle

Benedict T. Green et al.

JOURNAL OF ANIMAL SCIENCE (2019)

Review Pharmacology & Pharmacy

Piperine: Old Spice and New Nutraceutical?

Katarina Smilkov et al.

CURRENT PHARMACEUTICAL DESIGN (2019)

Review Chemistry, Medicinal

Phytochemical and pharmacological attributes of piperine: A bioactive ingredient of black pepper

Sergey Shityakov et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Review Biotechnology & Applied Microbiology

An overview of the biological production of 1-deoxynojirimycin: current status and future perspective

Wenli Zhang et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2019)

Review Biochemistry & Molecular Biology

DARK Classics in Chemical Neuroscience: Atropine, Scopolamine, and Other Anticholinergic Deliriant Hallucinogens

Anton M. Lakstygal et al.

ACS CHEMICAL NEUROSCIENCE (2019)

Article Plant Sciences

Selective dual cholinesterase inhibitors from Aconitum laeve

Hanif Ahmad et al.

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2018)

Article Plant Sciences

C18-Diterpenoid alkaloids from Delphinium anthriscifolium var. majus

Lian-Hai Shan et al.

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2018)

Article Chemistry, Medicinal

Four new diterpenoid alkaloids from Aconitum japonicum subsp subcuneatum

Hiroshi Yamashita et al.

JOURNAL OF NATURAL MEDICINES (2018)

Article Biochemistry & Molecular Biology

Norditerpenoid alkaloids of Delphinium denudatum as cholinesterase inhibitors

Hanif Ahmad et al.

BIOORGANIC CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Four New Diterpenoid Alkaloids from the Roots of Aconitum carmichaelii

Yu Li et al.

CHEMISTRY & BIODIVERSITY (2018)

Article Chemistry, Multidisciplinary

Expedient Construction of the Hexacycle of Franchetine

Zhengchao Lv et al.

CHEMISTRY-AN ASIAN JOURNAL (2018)

Article Biochemistry & Molecular Biology

C19-Norditerpenoid Alkaloids from Aconitum szechenyianum

Bei Song et al.

MOLECULES (2018)

Article Plant Sciences

Four new C19-diterpenoid alkaloids from Delphinium elatum

Hiroshi Yamashita et al.

PHYTOCHEMISTRY LETTERS (2018)

Article Chemistry, Organic

Total synthesis of C19-diterpenoid alkaloid: construction of a functionalized ABCDE-ring system

Mengchen Liu et al.

ORGANIC CHEMISTRY FRONTIERS (2018)

Article Chemistry, Organic

A Copper-Mediated Conjugate Addition Approach to Analogues of Aconitine-Type Diterpenoid Alkaloids

Nicolle A. Doering et al.

JOURNAL OF ORGANIC CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Norditerpenoid alkaloids from Delphinium pseudoaemulans C. Y. Yang et B. Wang

Wen-Juan Xue et al.

PHYTOCHEMISTRY (2018)

Article Integrative & Complementary Medicine

Three new diterpenoid alkaloids isolated from Aconitum brevicalcaratum

Shu Yan et al.

CHINESE JOURNAL OF NATURAL MEDICINES (2018)

Article Plant Sciences

Two new C-19-diterpenoid alkaloids from Aconitum tsaii

Gui-Qiong Li et al.

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2017)

Article Chemistry, Multidisciplinary

A Unifying Synthesis Approach to the C18-, C19-, and C20-Diterpenoid Alkaloids

Kevin G. M. Kou et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Article Chemistry, Multidisciplinary

Grandiflodines A and B, two novel diterpenoid alkaloids from Delphinium grandiflorum

Neng-Hua Chen et al.

RSC ADVANCES (2017)

Article Multidisciplinary Sciences

Diterpenoid Alkaloids from Delphinium anthriscifolium var. majus

Lian-Hai Shan et al.

SCIENTIFIC REPORTS (2017)

Article Biochemistry & Molecular Biology

Two Delphinium ramosum chemotypes, their biogeographical distribution and potential toxicity

Daniel Cook et al.

BIOCHEMICAL SYSTEMATICS AND ECOLOGY (2017)

Article Chemistry, Multidisciplinary

Two New C19-Diterpenoid Alkaloids with Anti-inflammatory Activity from Aconitum iochanicum

Ruihua Guo et al.

CHINESE JOURNAL OF CHEMISTRY (2017)

Article Chemistry, Multidisciplinary

Four new diterpenoid alkaloids with antitumor effect from Aconitum nagarum var. heterotrichum

Da-Ke Zhao et al.

CHINESE CHEMICAL LETTERS (2017)

Article Plant Sciences

Four new diterpenoid alkaloids from Delphinium elatum

Koji Wada et al.

PHYTOCHEMISTRY LETTERS (2016)

Article Plant Sciences

Iliensines A and B: Two new C19-diterpenoid alkaloids from Delphinium iliense

Ji-fa Zhang et al.

PHYTOCHEMISTRY LETTERS (2016)

Editorial Material Plant Sciences

The number of known plants species in the world and its annual increase

Maarten J. M. Christenhusz et al.

PHYTOTAXA (2016)

Article Chemistry, Medicinal

New C19-norditerpenoid Alkaloid from Delphinium shawurense

B. Zhao et al.

CHEMISTRY OF NATURAL COMPOUNDS (2015)

Article Chemistry, Medicinal

New norditerpenoid alkaloids from Aconitum vilmorinianum Komarov

Cui-Ling Chen et al.

JOURNAL OF NATURAL MEDICINES (2015)

Article Biochemistry & Molecular Biology

Diterpenoid alkaloids from Aconitum vilmorinianum

Tian-Peng Yin et al.

PHYTOCHEMISTRY (2015)

Article Plant Sciences

Unusual C19-diterpenoid alkaloids from Aconitum vilmorinianum var. patentipilum

Le Cai et al.

PHYTOCHEMISTRY LETTERS (2015)

Article Plant Sciences

Five new C19-diterpenoid alkaloids from Aconitum carmichaeli

Xiangdong Qin et al.

PHYTOCHEMISTRY LETTERS (2015)

Article Plant Sciences

Six new norditerpenoid alkaloids from Delphinium elatum

Koji Wada et al.

PHYTOCHEMISTRY LETTERS (2015)

Article Chemistry, Medicinal

New Alkaloids from Aconitum stapfianum

Tian-Peng Yin et al.

NATURAL PRODUCTS AND BIOPROSPECTING (2015)

Article Integrative & Complementary Medicine

Mining chemodiversity from biodiversity: pharmacophylogeny of medicinal plants of Ranunculaceae

Hao Da-Cheng et al.

CHINESE JOURNAL OF NATURAL MEDICINES (2015)

Article Crystallography

Crystal structure of lappaconitine-ium nitrate monohydrate, C32H47N3O12

Wenxiu Sun et al.

ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES (2014)

Review Developmental Biology

Plant Alkaloids that Cause Developmental Defects through the Disruption of Cholinergic Neurotransmission

Benedict T. Green et al.

BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS (2013)

Review Pharmacology & Pharmacy

Differences between opioids: pharmacological, experimental, clinical and economical perspectives

Asbjorn M. Drewes et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2013)

Review Chemistry, Medicinal

Plant Toxins That Affect Nicotinic Acetylcholine Receptors: A Review

Benedict T. Green et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2013)

Review Chemistry, Medicinal

Piper nigrum and Piperine: An Update

Murlidhar Meghwal et al.

PHYTOTHERAPY RESEARCH (2013)

Review Toxicology

Aspects of Datura poisoning and treatment

Edward P. Krenzelok

CLINICAL TOXICOLOGY (2010)

Article Neurosciences

Actions of piperidine alkaloid teratogens at fetal nicotinic acetylcholine receptors

Benedict T. Green et al.

NEUROTOXICOLOGY AND TERATOLOGY (2010)

Review Toxicology

Nicotinic plant poisoning

Leo J. Schep et al.

CLINICAL TOXICOLOGY (2009)

Review Food Science & Technology

Morus alba L. nature's functional tonic

Masood Sadiq Butt et al.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2008)

Review Cell Biology

Nicotinic agonists, antagonists, and modulators from natural sources

JW Daly

CELLULAR AND MOLECULAR NEUROBIOLOGY (2005)

Review Food Science & Technology

Poison hemlock (Conium maculatum L.)

J Vetter

FOOD AND CHEMICAL TOXICOLOGY (2004)

Review Agriculture, Multidisciplinary

Biomedical applications of poisonous plant research

LF James et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Larkspur poisoning: toxicology and alkaloid structure-activity relationships

KE Panter et al.

BIOCHEMICAL SYSTEMATICS AND ECOLOGY (2002)