☆ 4.7 Review

Critical Players and Therapeutic Targets in Chronic Itch

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Patient burden and quality of life in atopic dermatitis in US adults GI A population-based cross-sectional study

Jonathan I. Silverberg et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2018)

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Article Allergy

New mechanism underlying IL-31-induced atopic dermatitis

Jianghui Meng et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

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The Genetics of Chronic Itch: Gene Expression in the Skin of Patients with Atopic Dermatitis and Psoriasis with Severe Itch

Leigh A. Nattkemper et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)

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Efficacy and safety of lebrikizumab (an anti-IL-13 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical corticosteroids: A randomized, placebo-controlled phase II trial (TREBLE)

Eric L. Simpson et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2018)

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Improvement in itch and other psoriasis symptoms with brodalumab in phase 3 randomized controlled trials

A. B. Gottlieb et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2018)

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Circuit dissection of the role of somatostatin in itch and pain

Jing Huang et al.

NATURE NEUROSCIENCE (2018)

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Comparative transcriptome profiling of the human and mouse dorsal root ganglia: an RNA-seq-based resource for pain and sensory neuroscience research

Pradipta Ray et al.

PAIN (2018)

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Humanistic burden of chronic pruritus in patients with inflammatory dermatoses: Results of the European Academy of Dermatology and Venereology Network on Assessment of Severity and Burden of Pruritus (PruNet) cross-sectional trial

Sabine Steinke et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2018)

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IL-31 is crucial for induction of pruritus, but not inflammation, in contact hypersensitivity

Ayako Takamori et al.

SCIENTIFIC REPORTS (2018)

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Adding emollient bath additives to standard eczema management for children with eczema: the BATHE RCT

Miriam Santer et al.

HEALTH TECHNOLOGY ASSESSMENT (2018)

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Review Immunology

Type 2 innate lymphoid cells in the induction and resolution of tissue inflammation

Antonia Wallrapp et al.

IMMUNOLOGICAL REVIEWS (2018)

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Itch: From mechanism to (novel) therapeutic approaches

Gil Yosipovitch et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

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Molecular link between itch and atopic dermatitis

Tiphaine Voisin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Efficacy and safety of guselkumab in patients with psoriasis who have an inadequate response to ustekinumab: results of the randomized, double-blind, phase III NAVIGATE trial

R. G. Langley et al.

BRITISH JOURNAL OF DERMATOLOGY (2018)

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Efficacy and safety of ustekinumab treatment in adults with moderate-to-severe atopic dermatitis

Saakshi Khattri et al.

EXPERIMENTAL DERMATOLOGY (2017)

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The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons

Sebastian Zinn et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

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Expression of IL-22 in the Skin Causes Th2-Biased Immunity, Epidermal Barrier Dysfunction, and Pruritus via Stimulating Epithelial Th2 Cytokines and the GRP Pathway

Hongfei Lou et al.

JOURNAL OF IMMUNOLOGY (2017)

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When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council

Eric L. Simpson et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2017)

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Efficacy and safety of ixekizumab for the treatment of moderate-to-severe plaque psoriasis: Results through 108 weeks of a randomized, controlled phase 3 clinical trial (UNCOVER-3)

Andrew Blauvelt et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2017)

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Tildrakizumab versus placebo or etanercept for chronic plaque psoriasis (reSURFACE 1 and reSURFACE 2): results from two randomised controlled, phase 3 trials

Kristian Reich et al.

LANCET (2017)

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Leaky Gate Model: Intensity-Dependent Coding of Pain and Itch in the Spinal Cord

Shuohao Sun et al.

NEURON (2017)

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Anti-Interleukin-31 Receptor A Antibody for Atopic Dermatitis

Thomas Ruzicka et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Letter Medicine, General & Internal

Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis

Maurizio Mennini et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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A central neural circuit for itch sensation

Di Mu et al.

SCIENCE (2017)

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Aryl hydrocarbon receptor activation restores filaggrin expression via OVOL1 in atopic dermatitis

Gaku Tsuji et al.

CELL DEATH & DISEASE (2017)

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Distinct roles of NMB and GRP in itch transmission

Li Wan et al.

SCIENTIFIC REPORTS (2017)

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Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch

Landon K. Oetjen et al.

CELL (2017)

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Mediators of Chronic Pruritus in Atopic Dermatitis: Getting the Itch Out?

Nicholas K. Mollanazar et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2016)

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A prospective phase III, randomized, double-blind, placebo-controlled study of brodalumab in patients with moderate-to-severe plaque psoriasis

K. A. Papp et al.

BRITISH JOURNAL OF DERMATOLOGY (2016)

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The pruritus- and TH2-associated cytokine IL-31 promotes growth of sensory nerves

Micha Feld et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

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Roles of Mas-related G protein-coupled receptor X2 on mast cell-mediated host defense, pseudoallergic drug reactions, and chronic inflammatory diseases

Hariharan Subramanian et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

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The cell biology of acute itch

Dustin Green et al.

JOURNAL OF CELL BIOLOGY (2016)

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Increased Lipocalin-2 Contributes to the Pathogenesis of Psoriasis by Modulating Neutrophil Chemotaxis and Cytokine Secretion

Shuai Shao et al.

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Efficacy and safety of crisaborole ointment, a novel, nonsteroidal phosphodiesterase 4 (PDE4) inhibitor for the topical treatment of atopic dermatitis (AD) in children and adults

Amy S. Paller et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2016)

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Expression profiling of constitutive mast cells reveals a unique identity within the immune system

Daniel F. Dwyer et al.

NATURE IMMUNOLOGY (2016)

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Phase 3 Trials of Ixekizumab in Moderate-to-Severe Plaque Psoriasis

K. B. Gordon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

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Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis

E. L. Simpson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

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IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy

Boyi Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Peripheral and spinal 5-HT receptors participate in cholestatic itch and antinociception induced by bile duct ligation in rats

Bin Tian et al.

SCIENTIFIC REPORTS (2016)

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Molecular mechanisms of pruritus

J. Meng et al.

CURRENT RESEARCH IN TRANSLATIONAL MEDICINE (2016)

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TNFα induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1/syntaxin1/SNAP-25 mediated fusion

Jianghui Meng et al.

SCIENTIFIC REPORTS (2016)

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Calcitonin gene-related peptide: key regulator of cutaneous immunity

R. D. Granstein et al.

ACTA PHYSIOLOGICA (2015)

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Substance P activates human eosinophils

Mieke Raap et al.

EXPERIMENTAL DERMATOLOGY (2015)

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Comparison of ixekizumab with etanercept or placebo in moderate-to-severe psoriasis (UNCOVER-2 and UNCOVER-3): results from two phase 3 randomised trials

Christopher E. M. Griffiths et al.

LANCET (2015)

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STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch

Miho Shiratori-Hayashi et al.

NATURE MEDICINE (2015)

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HTR7 Mediates Serotonergic Acute and Chronic Itch

Takeshi Morita et al.

NEURON (2015)

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Phase 3 Studies Comparing Brodalumab with Ustekinumab in Psoriasis

M. Lebwohl et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

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CXCR3 chemokine receptor signaling mediates itch in experimental allergic contact dermatitis

Lintao Qu et al.

PAIN (2015)

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Periostin contributes to epidermal hyperplasia in psoriasis common to atopic dermatitis

Kazuhiko Arima et al.

ALLERGOLOGY INTERNATIONAL (2015)

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Efficacy, safety and usability of secukinumab administration by autoinjector/pen in psoriasis: a randomized, controlled trial (JUNCTURE)

C. Paul et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2015)

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Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

Dmitry Usoskin et al.

NATURE NEUROSCIENCE (2015)

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Periostin levels correlate with disease severity and chronicity in patients with atopic dermatitis

K. Kou et al.

BRITISH JOURNAL OF DERMATOLOGY (2014)

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Pharmacokinetics, pharmacodynamics and safety of QGE031 (ligelizumab), a novel high-affinity anti-IgE antibody, in atopic subjects

J. P. Arm et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2014)

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A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1

Ferda Cevikbas et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

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Neural peptidase endothelin-converting enzyme 1-regulates endothelin induced pruritus

Makiko Kido-Nakahara et al.

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Calcitonin Gene-Related Peptide Receptor Antagonists: New Therapeutic Agents for Migraine

Ian M. Bell

JOURNAL OF MEDICINAL CHEMISTRY (2014)

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Descending Control of Itch Transmission by the Serotonergic System via 5-HT1A-Facilitated GRP-GRPR Signaling

Zhong-Qiu Zhao et al.

NEURON (2014)

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Roles of glutamate, substance P, and gastrin-releasing peptide as spinal neurotransmitters of histaminergic and nonhistaminergic itch

Tasuku Akiyama et al.

PAIN (2014)

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The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch

Sarah R. Wilson et al.

CELL (2013)

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Dose-ranging study of lebrikizumab in asthmatic patients not receiving inhaled steroids

Michael Noonan et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

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Histamine induces proliferation in keratinocytes from patients with atopic dermatitis through the histamine 4 receptor

Franziska Glatzer et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

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Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis

Ellen H. van den Bogaard et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

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Increased TRPV4 Expression in Urinary Bladder and Lumbosacral Dorsal Root Ganglia in Mice with Chronic Overexpression of NGF in Urothelium

Beatrice M. Girard et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2013)

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A subpopulation of nociceptors specifically linked to itch

Liang Han et al.

NATURE NEUROSCIENCE (2013)

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Peptidergic CGRPα Primary Sensory Neurons Encode Heat and Itch and Tonically Suppress Sensitivity to Cold

Eric S. McCoy et al.

NEURON (2013)

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The Cells and Circuitry for Itch Responses in Mice

Santosh K. Mishra et al.

SCIENCE (2013)

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Topical Surfactant-Induced Pruritus: Involvement of Histamine Released from Epidermal Keratinocytes

Yoshihiro Inami et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2013)

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Chronic Pain States: Pharmacological Strategies to Restore Diminished Inhibitory Spinal Pain Control

Hanns Ulrich Zeilhofer et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 52 (2012)

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Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions

Andreas E. Kremer et al.

HEPATOLOGY (2012)

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Leukotriene B4-Driven Neutrophil Recruitment to the Skin Is Essential for Allergic Skin Inflammation

Michiko K. Oyoshi et al.

IMMUNITY (2012)

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IL-33: A Novel Danger Signal System in Atopic Dermatitis

Ferda Cevikbas et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2012)

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Mechanisms of Itch Evoked by β-Alanine

Qin Liu et al.

JOURNAL OF NEUROSCIENCE (2012)

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The majority of dorsal spinal cord gastrin releasing peptide is synthesized locally whereas neuromedin B is highly expressed in pain- and itch-sensing somatosensory neurons

Michael S. Fleming et al.

MOLECULAR PAIN (2012)

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Endothelin-1 induces itch and pain in the mouse cheek model

Lenyta Oliveira Gomes et al.

LIFE SCIENCES (2012)

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FAST SYNAPTIC INHIBITION IN SPINAL SENSORY PROCESSING AND PAIN CONTROL

Hanns Ulrich Zeilhofer et al.

PHYSIOLOGICAL REVIEWS (2012)

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Involvement of leukotriene B4 in spontaneous itch-related behaviour in NC mice with atopic dermatitis-like skin lesions

Tsugunobu Andoh et al.

EXPERIMENTAL DERMATOLOGY (2011)

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Interrupting IL-6-receptor signaling improves atopic dermatitis but associates with bacterial superinfection

Alexander A. Navarini et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2011)

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Caveolin-1 Assembles Type 1 Inositol 1,4,5-Trisphosphate Receptors and Canonical Transient Receptor Potential 3 Channels into a Functional Signaling Complex in Arterial Smooth Muscle Cells

Adebowale Adebiyi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

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Cutaneous Denervation of Psoriasiform Mouse Skin Improves Acanthosis and Inflammation in a Sensory Neuropeptide-Dependent Manner

Stephen M. Ostrowski et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2011)

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Facial injections of pruritogens or algogens elicit distinct behavior responses in rats and excite overlapping populations of primary sensory and trigeminal subnucleus caudalis neurons

Amanda Klein et al.

JOURNAL OF NEUROPHYSIOLOGY (2011)

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HISTAMINE H1, H3 AND H4 RECEPTORS ARE INVOLVED IN PRURITUS

K. Rossbach et al.

NEUROSCIENCE (2011)

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Lebrikizumab Treatment in Adults with Asthma

Jonathan Corren et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

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Keratinocyte expression of calcitonin gene-related peptide β: Implications for neuropathic and inflammatory pain mechanisms

Quanzhi Hou et al.

PAIN (2011)

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Gastrin-releasing peptide induces itch-related responses through mast cell degranulation in mice

Tsugunobu Andoh et al.

PEPTIDES (2011)

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Interleukin-13: prospects for new treatments

C. E. Brightling et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2010)

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Positive treatment effects of ustekinumab in psoriasis: Analysis of lesional and systemic parameters

Manjula Reddy et al.

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Novel Management of Pruritus in Patients Treated With IL-2 for Metastatic Renal Cell Carcinoma and Malignant Melanoma

Sung Ho Lee et al.

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Cathepsin S Elicits Itch and Signals via Protease-Activated Receptors

Vemuri B. Reddy et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2010)

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Facial Injections of Pruritogens and Algogens Excite Partly Overlapping Populations of Primary and Second-Order Trigeminal Neurons in Mice

T. Akiyama et al.

JOURNAL OF NEUROPHYSIOLOGY (2010)

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Neuronal circuitry for pain processing in the dorsal horn

Andrew J. Todd

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TRPC channels and store-operated Ca2+ entry

Gines M. Salido et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2009)

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Calcitonin gene-related peptide modulates interleukin-13 in circulating cutaneous lymphocyte-associated antigen-positive T cells in patients with atopic dermatitis

C. Antunez et al.

BRITISH JOURNAL OF DERMATOLOGY (2009)

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Scratching Behavior and Fos Expression in Superficial Dorsal Horn Elicited by Protease-Activated Receptor Agonists and Other Itch Mediators in Mice

Tasuku Akiyama et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)

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TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms

Noritaka Imamachi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Erythropoietin or Darbepoetin for patients with cancer - meta-analysis based on individual patient data

Julia Bohlius et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2009)

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Involvement of serotonin receptors 5-HT1 and 5-HT2 in 12(S)-HPETE-induced scratching in mice

Dae-Kwon Kim et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2008)

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Neuropeptides activate human mast cell degranulation and chemokine production

Marianna Kulka et al.

IMMUNOLOGY (2008)

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Intradermal administration of thymic stromal lymphopoietin induces a T cell- and eosinophil-dependent systemic Th2 inflammatory response

Heidi K. Jessup et al.

JOURNAL OF IMMUNOLOGY (2008)

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International Union of Pharmacology. LXVIII. Mammalian Bombesin Receptors: Nomenclature, Distribution, Pharmacology, Signaling, and Functions in Normal and Disease States

R. T. Jensen et al.

PHARMACOLOGICAL REVIEWS (2008)

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The role of selected neuropeptides in pathogenesis of atopic dermatitis

J. Salomon et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2008)

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A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord

Yan-Gang Sun et al.

NATURE (2007)

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TRP channels as novel players in the pathogenesis and therapy of itch

Tamds Biro et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2007)

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Thromboxane A2 induces itch-associated responses through TP receptors in the skin in mice

Tsugunobu Andoh et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2007)

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Letter Allergy

Human mast cells are capable of serotonin synthesis and release

Nataliya M. Kushnir-Sukhov et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2007)

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12(S)-HPETE induces itch-associated scratchings in mice

Dae-Kwon Kim et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2007)

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Phospholipase Cβ3 mediates the scratching response activated by the histamine H1 receptor on C-fiber nociceptive neurons

Sang-Kyou Han et al.

NEURON (2006)

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Frontiers in pruritus research:: scratching the brain for more effective itch therapy

R Paus et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

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IL-31: A new link between T cells and pruritus in atopic skin inflammation

E Sonkoly et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2006)

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Potent pruritogenic action of tryptase mediated by PAR-2 receptor and its involvement in anti-pruritic effect of nafamostat mesilate in mice

H Ui et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2006)

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Expression of BLT1 leukotriene B4 receptor on the dorsal root ganglion neurons in mice

T Andoh et al.

MOLECULAR BRAIN RESEARCH (2005)

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Expression and secretion of procalcitonin and calcitonin gene-related peptide by adherent monocytes and by macrophage-activated adipocytes

P Linscheid et al.

CRITICAL CARE MEDICINE (2004)

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Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice

SR Dillon et al.

NATURE IMMUNOLOGY (2004)

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H1 histamine receptor mediates inflammatory responses in human keratinocytes

ML Giustizieri et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2004)

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Antipruritic effects of two different 5-HT3 receptor antagonists and an antihistamine in haemodialysis patients

E Weisshaar et al.

EXPERIMENTAL DERMATOLOGY (2004)

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Involvement of histamine H4 and H1 receptors in scratching induced by histamine receptor agonists in BalbC mice

JK Bell et al.

BRITISH JOURNAL OF PHARMACOLOGY (2004)

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Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens

M Schmelz et al.

JOURNAL OF NEUROPHYSIOLOGY (2003)

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The two faces of IL-6 on Th1/Th2 differentiation

S Diehl et al.

MOLECULAR IMMUNOLOGY (2002)

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Neuromediators - a crucial component of the skin immune system

TA Luger

JOURNAL OF DERMATOLOGICAL SCIENCE (2002)

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Enhanced contact hypersensitivity in human monocyte chemoattractant protein-1 transgenic mouse

N Mizumoto et al.

IMMUNOBIOLOGY (2001)

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Scratch induction in the rat by intradermal serotonin: a model for pruritus

JS Thomsen et al.

ACTA DERMATO-VENEREOLOGICA (2001)

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Acute effects of substance P and calcitonin gene-related peptide in human skin - A microdialysis study

C Weidner et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2000)

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