Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 17, Pages -Publisher
MDPI
DOI: 10.3390/ijms231710128
Keywords
neuroinflammation; multiple sclerosis; experimental autoimmune encephalomyelitis; gut-brain axis; microbiota-derived metabolites
Funding
- Swiss National Science Foundation [310030_192738]
- Biaggi Foundation
- Swiss National Science Foundation (SNF) [310030_192738] Funding Source: Swiss National Science Foundation (SNF)
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Microbiota-derived metabolites play a crucial role in neuroinflammation and may offer new therapeutic avenues for treating neuroinflammatory diseases by targeting the gut-brain axis.
Microbiota-derived metabolites are important molecules connecting the gut to the brain. Over the last decade, several studies have highlighted the importance of gut-derived metabolites in the development of multiple sclerosis (MS). Indeed, microbiota-derived metabolites modulate the immune system and affect demyelination. Here, we discuss the current knowledge about microbiota-derived metabolites implications in MS and in different mouse models of neuroinflammation. We focus on the main families of microbial metabolites that play a role during neuroinflammation. A better understanding of the role of those metabolites may lead to new therapeutical avenues to treat neuroinflammatory diseases targeting the gut-brain axis.
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