4.7 Review

Erythropoiesis and Malaria, a Multifaceted Interplay

Related references

Note: Only part of the references are listed.
Article Immunology

Morphological and Transcriptional Changes in Human Bone Marrow During Natural Plasmodium vivax Malaria Infections

Marcelo A. M. Brito et al.

Summary: This study reveals the presence of Plasmodium vivax parasites in the bone marrow of malaria patients and the associated dyserythropoiesis and ineffective erythropoiesis. Furthermore, it shows that during infections, genes related to erythroid maturation are down-regulated while immune response genes are up-regulated.

JOURNAL OF INFECTIOUS DISEASES (2022)

Article Environmental Sciences

MiRNA: Biological Regulator in Host-Parasite Interaction during Malaria Infection

Poonam Kataria et al.

Summary: Malaria is a life-threatening disease caused by parasite-infected mosquitoes. Recent research has established the link between microRNAs and various diseases, including malaria. MicroRNAs can detect malaria infection and serve as biomarkers for diagnosis and management of the disease.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

Article Parasitology

Proteomic identification of the contents of small extracellular vesicles from in vivo Plasmodium yoelii infection

Karina P. De Sousa et al.

Summary: This study identified the protein cargo of sEVs in the plasma of P. yoelii-infected mice. The identified proteins include vaccine candidates, potential targets of T cell immunoreactivity, and proteins involved in metabolic processes, regulation, homeostasis, and immunity. These findings enhance our understanding of the host-parasite interactions and provide potential targets for malaria vaccination.

INTERNATIONAL JOURNAL FOR PARASITOLOGY (2022)

Article Biochemistry & Molecular Biology

Malaria parasites release vesicle subpopulations with signatures of different destinations

Paula Abou Karam et al.

Summary: Researchers have discovered that malaria parasites use extracellular vesicles (EVs) to deliver different subpopulations of proteins to host cells, leading to varied host responses. Small EVs are enriched in complement-system proteins, while large EVs contain proteasome subunits. Small EVs also have a higher ability to fuse with early endosome liposomes compared to large EVs.

EMBO REPORTS (2022)

Article Multidisciplinary Sciences

Host cell maturation modulates parasite invasion and sexual differentiation in Plasmodium berghei

Franziska Hentzschel et al.

Summary: This study provides a comprehensive analysis of rodent P. berghei infection using flow cytometry and single-cell RNA sequencing. The researchers identified CD71 as a host receptor for reticulocyte invasion and found that parasites adapt metabolically to the host cell environment. Transcriptional analysis and functional assays revealed the importance of nutrient-dependent tropism for gametocyte formation in reticulocytes.

SCIENCE ADVANCES (2022)

Review Infectious Diseases

Extracellular vesicles in malaria: an agglomeration of two decades of research

Tosin Opadokun et al.

Summary: Malaria, caused by Plasmodium parasites, remains a global public health issue. Extracellular vesicles released during malaria infection are believed to play key roles in disease pathogenesis and are seen as potential therapeutic tools and biomarkers. Further research on EV biology in malaria is proposed to enhance disease prevention and control efforts.

MALARIA JOURNAL (2021)

Article Infectious Diseases

Phagocytosis and activation of bone marrow-derived macrophages by Plasmodium falciparum gametocytes

Yolanda Corbett et al.

Summary: The study suggests that developing gametocytes interact differently with host innate immune cells and early and late gametocytes act differently as targets for innate immune responses.

MALARIA JOURNAL (2021)

Letter Medicine, General & Internal

Hidden Biomass of Intact Malaria Parasites in the Human Spleen

Steven Kho et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Parasitology

The roles of parasite-derived extracellular vesicles in disease and host-parasite communication

Claudia Carrera-Bravo et al.

Summary: In recent years, it has been discovered that parasites interact with their hosts through extracellular vesicles (EVs), which contain essential substances for genetic exchange, biomarker identification, and diagnosis of pathological diseases. Parasite-secreted EVs play a crucial role as information transmitters in the early stages of host-parasite interaction and host-cell colonization. Researchers have found that EVs have the potential to be developed as diagnostic, immunomodulation, and therapeutic alternatives for parasitic diseases.

PARASITOLOGY INTERNATIONAL (2021)

Article Medicine, General & Internal

Evaluation of splenic accumulation and colocalization of immature reticulocytes and Plasmodium vivax in asymptomatic malaria: A prospective human splenectomy study

Steven Kho et al.

Summary: A study in malaria-endemic Papua and non-endemic France found high concentrations of immature reticulocytes in the spleens of individuals infected with Plasmodium vivax, suggesting a niche for parasite survival. Additionally, P. vivax-infected erythrocytes of all stages accumulated in the spleen, indicating a potential cryptic endosplenic lifecycle. These findings provide insights into P. vivax-specific adaptations for survival and replication.

PLOS MEDICINE (2021)

Review Parasitology

The Human Spleen in Malaria: Filter or Shelter?

Benoit Henry et al.

TRENDS IN PARASITOLOGY (2020)

Review Genetics & Heredity

Red Blood Cells as Potential Repositories of MicroRNAs in the Circulatory System

Liping Sun et al.

FRONTIERS IN GENETICS (2020)

Article Biochemistry & Molecular Biology

Antibody-Free Labeling of Malaria-Derived Extracellular Vesicles Using Flow Cytometry

Elya Dekel et al.

BIOMEDICINES (2020)

Article Infectious Diseases

The characterization of extracellular vesicles-derived microRNAs in Thai malaria patients

Nutpakal Ketprasit et al.

MALARIA JOURNAL (2020)

Review Biochemistry & Molecular Biology

Exosomes and Ectosomes in Intercellular Communication

Jacopo Meldolesi

CURRENT BIOLOGY (2018)

Article Multidisciplinary Sciences

Malaria infected red blood cells release small regulatory RNAs through extracellular vesicles

Kehinde Adebayo Babatunde et al.

SCIENTIFIC REPORTS (2018)

Article Multidisciplinary Sciences

Plasmodium gametocytes display homing and vascular transmigration in the host bone marrow

Mariana De Niz et al.

SCIENCE ADVANCES (2018)

Article Multidisciplinary Sciences

Plasmodium falciparum gametocyte-infected erythrocytes do not adhere to human primary erythroblasts

Gaelle Neveu et al.

SCIENTIFIC REPORTS (2018)

Article Medicine, Research & Experimental

Biology of Malaria Transmission

Elamaran Meibalan et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2017)

Article Multidisciplinary Sciences

Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors

Xavier Sisquella et al.

NATURE COMMUNICATIONS (2017)

Review Hematology

Advances in understanding erythropoiesis: evolving perspectives

Satish K. Nandakumar et al.

BRITISH JOURNAL OF HAEMATOLOGY (2016)

Article Multidisciplinary Sciences

Reversible host cell remodeling underpins deformability changes in malaria parasite sexual blood stages

Megan Dearnley et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Biotechnology & Applied Microbiology

A comprehensive joint analysis of the long and short RNA transcriptomes of human erythrocytes

Jennifer F. Doss et al.

BMC GENOMICS (2015)

Review Parasitology

Exosomes and Other Extracellular Vesicles: The New Communicators in Parasite Infections

Gillian Coakley et al.

TRENDS IN PARASITOLOGY (2015)

Review Cell Biology

Biological properties of extracellular vesicles and their physiological functions

Maria Yanez-Mo et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

Article Parasitology

Reticuliocytes from cryopreserved erythroblasts support Plasmodium vivax infection in vitro

Tetsuya Furuya et al.

PARASITOLOGY INTERNATIONAL (2014)

Article Cell Biology

Plasmodium falciparum transmission stages accumulate in the human bone marrow

Regina Joice et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

Review Immunology

Regulation of immune responses by extracellular vesicles

Paul D. Robbins et al.

NATURE REVIEWS IMMUNOLOGY (2014)

Article Biochemistry & Molecular Biology

Cell-Cell Communication between Malaria-Infected Red Blood Cells via Exosome-like Vesicles

Neta Regev-Rudzki et al.

Article Multidisciplinary Sciences

Severe malaria is associated with parasite binding to endothelial protein C receptor

Louise Turner et al.

NATURE (2013)

Article Infectious Diseases

Suppression of erythroid development in vitro by Plasmodium vivax

Tasanee Panichakul et al.

MALARIA JOURNAL (2012)

Article Cell Biology

Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3ζ

David M. Patrick et al.

GENES & DEVELOPMENT (2010)

Article Infectious Diseases

Augmented plasma microparticles during acute Plasmodium vivax infection

Fernanda M. F. Campos et al.

MALARIA JOURNAL (2010)

Review Immunology

Innate inflammatory response to the malarial pigment hemozoin

Marina T. Shio et al.

MICROBES AND INFECTION (2010)

Article Hematology

Exosomes in erythropoiesis

M. Vidal

TRANSFUSION CLINIQUE ET BIOLOGIQUE (2010)

Article Hematology

Retention of erythrocytes in the spleen: a double-edged process in human malaria

Pierre A. Buffet et al.

CURRENT OPINION IN HEMATOLOGY (2009)

Article Biochemistry & Molecular Biology

Molecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites

Jake Baum et al.

NUCLEIC ACIDS RESEARCH (2009)

Article Multidisciplinary Sciences

Hemozoin (Malarial Pigment) Directly Promotes Apoptosis of Erythroid Precursors

Abigail A. Lamikanra et al.

PLOS ONE (2009)

Article Multidisciplinary Sciences

Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis

Ke Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Education, Scientific Disciplines

Malaria, erythrocytic infection, and anemia

K. Haldar et al.

Hematology-American Society of Hematology Education Program (2009)

Review Chemistry, Medicinal

4-hydroxynonenal: A membrane lipid oxidation product of medicinal interest

G. Poli et al.

MEDICINAL RESEARCH REVIEWS (2008)

Article Parasitology

Production of erythropoietic cells in vitro for continuous culture of Plasmodium vivax

Panichakul Tasanee et al.

INTERNATIONAL JOURNAL FOR PARASITOLOGY (2007)

Article Biochemistry & Molecular Biology

The basis of the immunomodulatory activity of malaria pigment (hemozoin)

Clare K. Carney et al.

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2006)

Article Parasitology

Oxidative stress in malaria parasite-infected erythrocytes: host-parasite interactions

K Becker et al.

INTERNATIONAL JOURNAL FOR PARASITOLOGY (2004)

Article Immunology

Evidence for the involvement of VAR2CSA in pregnancy-associated malaria

A Salanti et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2004)

Article Immunology

Central role of the spleen in malaria parasite clearance

K Chotivanich et al.

JOURNAL OF INFECTIOUS DISEASES (2002)

Article Immunology

Role of Th1 and Th2 cytokines in immune response to uncomplicated Plasmodium falciparum malaria

D Torre et al.

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY (2002)

Article Multidisciplinary Sciences

The structure of malaria pigment β-haematin

S Pagola et al.

NATURE (2000)