Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 17, Pages -Publisher
MDPI
DOI: 10.3390/ijms23179937
Keywords
ubiquitination; NEDD4 subfamily; Smurf1; osteogenesis; tooth
Funding
- National Natural Science Foundation of China [81870737]
- Natural Science Foundation of Guangdong Province [2021A1515011779]
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This article focuses on the regulatory role of the NEDD4 subfamily in osteogenesis, providing detailed insights into its specific roles in downstream substrates and upstream regulatory mechanisms. Additionally, an overview is provided on the involvement of E3 ligases and deubiquitinases in the development, repair, and regeneration of teeth, another mineralized tissue.
Protein ubiquitination is a precisely controlled enzymatic cascade reaction belonging to the post-translational modification of proteins. In this process, E3 ligases catalyze the binding of ubiquitin (Ub) to protein substrates and define specificity. The neuronally expressed developmentally down-regulated 4 (NEDD4) subfamily, belonging to the homology to E6APC terminus (HECT) class of E3 ligases, has recently emerged as an essential determinant of multiple cellular processes in different tissues, including bone and tooth. Here, we place special emphasis on the regulatory role of the NEDD4 subfamily in the molecular and cell biology of osteogenesis. We elucidate in detail the specific roles, downstream substrates, and upstream regulatory mechanisms of the NEDD4 subfamily. Further, we provide an overview of the involvement of E3 ligases and deubiquitinases in the development, repair, and regeneration of another mineralized tissue-tooth.
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