Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 19, Pages -Publisher
MDPI
DOI: 10.3390/ijms231911582
Keywords
enhancer RNA; eRNA; cancer; neurodegenerative disorder; cardiovascular disease; metabolic disease; transcriptional regulation
Funding
- National Natural Science Foundation of China [32270708, 82203195]
- Shanghai Pujiang Program [21PJ1401700, 20PJ1400700]
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This review summarized recent studies on the pathological mechanisms and potential clinical utility of eRNAs in human diseases. The findings indicate the significant therapeutic potential of eRNAs in diagnosis, prognosis, and treatment.
Enhancer RNAs (eRNAs), a class of non-coding RNAs (ncRNAs) transcribed from enhancer regions, serve as a type of critical regulatory element in gene expression. There is increasing evidence demonstrating that the aberrant expression of eRNAs can be broadly detected in various human diseases. Some studies also revealed the potential clinical utility of eRNAs in these diseases. In this review, we summarized the recent studies regarding the pathological mechanisms of eRNAs as well as their potential utility across human diseases, including cancers, neurodegenerative disorders, cardiovascular diseases and metabolic diseases. It could help us to understand how eRNAs are engaged in the processes of diseases and to obtain better insight of eRNAs in diagnosis, prognosis or therapy. The studies we reviewed here indicate the enormous therapeutic potency of eRNAs across human diseases.
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