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Expression of p16INK4a prevents cancer and promotes aging in lymphocytes
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Programmed death ligand 1 is over-expressed by neutrophils in the blood of patients with active tuberculosis
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Programmed death-1 (PD-1)/PD-1 ligand pathway-mediated immune responses against human T-lymphotropic virus type 1 (HTLV-1) in HTLV-1-associated myelopathy/tropical spastic paraparesis and carriers with autoimmune disorders
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HUMAN IMMUNOLOGY (2011)
Age-related changes in natural killer cell receptors from childhood through old age
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HUMAN IMMUNOLOGY (2011)
Age-related increases in PGD2 expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice
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Alterations in Marginal Zone Macrophages and Marginal Zone B Cells in Old Mice
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Immunosenescence of Human Natural Killer Cells
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CLINICAL MICROBIOLOGY REVIEWS (2010)
Cell-Intrinsic Defects in the Proliferative Response of Antiviral Memory CD8 T Cells in Aged Mice upon Secondary Infection
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Age-Associated Decrease in TLR Function in Primary Human Dendritic Cells Predicts Influenza Vaccine Response
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Immunization with Different Viral Antigens Alters the Pattern of T Cell Exhaustion and Latency in Herpes Simplex Virus Type 1-Infected Mice
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KLRG1-more than a marker for T cell senescence
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AGE (2009)
Expression of p16INK4a in peripheral blood T-cells is a biomarker of human aging
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Zinc improves the development of human CD34+cell progenitors towards NK cells and increases the expression of GATA-3 transcription factor in young and old ages
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IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells
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BLOOD (2009)
Redefining Chronic Viral Infection
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CELL (2009)
Aging is associated with a numerical and functional decline in plasmacytoid dendritic cells, whereas myeloid dendritic cells are relatively unaltered in human peripheral blood
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HUMAN IMMUNOLOGY (2009)
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Negative Immune Regulator Tim-3 Is Overexpressed on T Cells in Hepatitis C Virus Infection and Its Blockade Rescues Dysfunctional CD4+ and CD8+ T Cells
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Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
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Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
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Limited expansion of virus-specific CD8 T cells in the aged environment
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A double-negative (IgD-CD27-) B cell population is increased in the peripheral blood of elderly people
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CD28- T cells: their role in the age-associated decline of immune function
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Impaired immune responses in the lungs of aged mice following influenza infection
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Impaired function of human T-lymphotropic virus type 1 (HTLV-1)-specific CD8+ T cells in HTLV-1-associated neurologic disease
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BLOOD (2008)
Ageing is associated with diminished apoptotic cell clearance in vivo
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Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization
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A fingerprint left by cytomegalovirus infection in the human T cell compartment
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Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus
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Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection
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Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals
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Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection
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Programmed death (PD)-1:PD-ligand 1/PD-ligand 2 pathway inhibits T cell effector functions during human tuberculosis
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Long-term care facilities: A cornucopia of viral pathogens
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Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies
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IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
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Telomere attrition induces a DNA double-strand break damage signal that reactivates p53 transcription in HTLV-I leukemic cells
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Molecular signature of CD8+ T cell exhaustion during chronic viral infection
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The cytomegalovirus-specific CD4+ T-cell response expands with age and markedly alters the CD4+ T-cell repertoire
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Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection
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IL-10, T cell exhaustion and viral persistence
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IMMUNOLOGY (2007)
Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates
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Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction
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Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis -: CREB and NF-κB as key regulators
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IMMUNITY (2005)
The impact of telomere erosion on memory CD8+ T cells in patients with X-linked lymphoproliferative syndrome
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MECHANISMS OF AGEING AND DEVELOPMENT (2005)
Functional re-expression of CCR7 on CMV-specific CD8+ T cells upon antigenic stimulation
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Reciprocal age related change in natural killer cell receptors for MHC class I
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Regulation of aged humoral immune defense against pneumococcal bacteria by IgM memory B cell
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IFN-γ-dependent transcription of MHC class IIIA is impaired in macrophages from aged mice
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Changing patterns of dominant TCR usage with maturation of an EBV-specific cytotoxic T cell response
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