Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 18, Pages -Publisher
MDPI
DOI: 10.3390/ijms231810281
Keywords
UC; CD; pregnancy; cytokines; IL-6; IL-22
Funding
- CEGIIR
- University of Alberta Department of Medicine
- University of Alberta Department of Gastroenterology
- Mount Sinai Hospital Department of Medicine
Ask authors/readers for more resources
This study conducted a longitudinal analysis of cytokines in healthy pregnant women and pregnant women with IBD, and found that maternal serum cytokines during pregnancy are influenced by IBD, disease activity, and medications. Active UC was associated with an elevation in IL-21, while active CD was associated with elevated IFN-gamma, IL-6, and IL-21. Additionally, T1 serum cytokine levels of IL-22 and IL-6 were correlated with worse IBD disease activity throughout pregnancy in women with UC and CD, respectively.
Inflammatory bowel diseases (IBD), including Ulcerative Colitis (UC) and Crohn's disease (CD), are inflammatory conditions of the intestinal tract that affect women in their reproductive years. Pregnancy affects Th1- and Th2-cytokines, but how these changes occur during pregnancy in IBD is unclear. We performed a longitudinal profiling of serum cytokines in a cohort of 11 healthy pregnant women and 76 pregnant women with IBD from the first trimester of pregnancy to the first 12 months post-partum. Participants were monitored for biochemical disease activity (C-reactive protein [CRP] and fecal calprotectin [FCP]) and clinical activities. Maternal cytokines were measured using ELISA. We identified changes in Th1 and Th17 cytokines throughout pregnancy in healthy pregnant women. During pregnancy, maternal serum cytokine expressions were influenced by IBD, disease activity, and medications. Active UC was associated with an elevation in IL-21, whereas active CD was associated with elevated IFN-gamma, IL-6, and IL-21. Interestingly, T1 serum cytokine levels of IL-22 (>0.624 pg/mL) and IL-6 (>0.648 pg/mL) were associated with worse IBD disease activity throughout pregnancy in women with UC and CD, respectively. This shows serum cytokines in pregnancy differ by IBD, disease activity, and medications. We show for the first time that T1 IL-22 and IL-6 correlate with IBD disease course throughout pregnancy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available