Delayed Diagnosis of Congenital Combined Pituitary Hormone Deficiency including Severe Growth Hormone Deficiency in Children with Persistent Neonatal Hypoglycemia-Case Reports and Review

Review Endocrinology & Metabolism

Diagnosis of GH Deficiency Without GH Stimulation Tests

Anastasia Ibba et al.

Summary: Growth hormone deficiency is the most common pituitary hormone deficiency in childhood, and can be diagnosed with GH stimulation testing. However, in some cases, GHD can be diagnosed without the need for stimulation testing.

FRONTIERS IN ENDOCRINOLOGY (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

Anabolic Deficiencies in Heart Failure Ready for Prime Time?

Raffaele Napoli et al.

CARDIOLOGY CLINICS (2022)

Add to Collection

Article Endocrinology & Metabolism

Pubertal induction and transition to adult sex hormone replacement in patients with congenital pituitary or gonadal reproductive hormone deficiency: an Endo-ERN clinical practice guideline

A. Nordenstrom et al.

Summary: This study aimed to create practice guidelines for clinical assessment and puberty induction in individuals with congenital pituitary or gonadal hormone deficiency. A multidisciplinary approach was used to address medical, social, and psychological issues of these patients.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2022)

Add to Collection

Article Cell Biology

Whole Exome Sequencing Points towards a Multi-Gene Synergistic Action in the Pathogenesis of Congenital Combined Pituitary Hormone Deficiency

Amalia Sertedaki et al.

Summary: This study aimed to uncover the genetic etiology of CPHD due to congenital hypopituitarism using whole exome sequencing. The findings suggest that CPHD may be an oligogenic disease and there is a genetic overlap with congenital hypogonadotropic hypogonadism.

CELLS (2022)

Add to Collection

Article Medicine, General & Internal

Presentation and diagnosis of childhood-onset combined pituitary hormone deficiency: A single center experience from over 30 years

Johanna Hietamaki et al.

Summary: This study describes the clinical spectrum and genetic etiologies of childhood-onset combined pituitary hormone deficiency (CPHD), estimates the population-level incidence of congenital CPHD, and identifies early height growth deflection as a common clinical feature in these patients.

ECLINICALMEDICINE (2022)

Add to Collection

Article Neurosciences

Distribution of growth hormone-responsive cells in the brain of rats and mice

Frederick Wasinski et al.

Summary: The study revealed a relatively similar distribution of GH-responsive cells in the brains of rats and mice, but some species-specific differences exist, particularly in the responsiveness to GH in distinct populations of cholinergic neurons.

BRAIN RESEARCH (2021)

Add to Collection

Review Cell Biology

Central Regulation of Metabolism by Growth Hormone

Jose Donato et al.

Summary: Growth hormone plays a crucial role in regulating metabolism in the brain, affecting food intake, energy expenditure, blood sugar levels, and neuroendocrine changes. It acts as a hormonal factor that conveys homeostatic information to the brain to produce metabolic adjustments in order to promote energy homeostasis.

CELLS (2021)

Add to Collection

Article Endocrinology & Metabolism

The Complex World of Regulation o f Pituitary Growth Hormone Secretion: The Role of Ghrelin, Klotho, and Nesfatins in It

Jesus Devesa

Summary: In recent years, the classic concept of pituitary GH regulation by somatostatin and GHRH has changed with the discovery of peripheral hormones like ghrelin, nesfatins, and klotho. These hormones play important roles in energy and mineral homeostasis regulation, impacting the synthesis and secretion of pituitary GH.

FRONTIERS IN ENDOCRINOLOGY (2021)

Add to Collection

Review Pediatrics

Congenital Hypopituitarism During the Neonatal Period: Epidemiology, Pathogenesis, Therapeutic Options, and Outcome

Laura Bosch i Ara et al.

Summary: Congenital hypopituitarism (CH) is a disorder characterized by deficiency in one or more pituitary hormones. The incidence is 1 in 4,000 to 1 in 10,000, with the majority of cases being sporadic. CH pathogenesis involves mutations in various genes such as HESX1, PROP1, and POU1F1. Clinical manifestations range from severe midline developmental disorders to isolated hormone deficiencies.

FRONTIERS IN PEDIATRICS (2021)

Add to Collection

Review Genetics & Heredity

Congenital hypopituitarism due to novel compound heterozygous POU1F1 gene mutation: A case report and review of the literature

Wei-Yu Chen et al.

Summary: An 8-month-old girl presented with features of congenital hypopituitarism and was found to have a compound heterozygous mutation of the POU1F1 gene through whole exome sequencing. This mutation, c.662T>C, is reported for the first time in the literature. The study illustrates the utility of WES in early diagnosis of congenital hypopituitarism, improving prognosis, and preventing irreversible deficits.

MOLECULAR GENETICS AND METABOLISM REPORTS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Cell Proliferation in the Piriform Cortex of Rats with Motor Cortex Ablation Treated with Growth Hormone and Rehabilitation

Margarita Heredia et al.

Summary: The study found that GH treatment and rehabilitation significantly improved the motor deficit caused by the injury and promoted cell proliferation in the PC of the injured side of the brain. This increased cell proliferation may be related to the observed improvement and could be involved in compensatory mechanisms of the brain after injury.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Contribution of Ghrelin to the Pathogenesis of Growth Hormone Deficiency

Andrzej Lewinski et al.

Summary: This review discussed the interactions between ghrelin and the GH-IGF-1 axis in individuals with GHD, suggesting their possible involvement in the pathogenesis of unexplained cases of GHD. It also highlighted the impact of Helicobacter pylori-related chronic gastritis on ghrelin levels and the modification of ghrelin action by gastrointestinal tract microflora. Additionally, the review described the mutual relationships between ghrelin and the TSH-FT4/FT3 axis in growth and metabolic processes, as well as the potential diagnostic and therapeutic applications of GH secretagogue receptor analogues.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Review Endocrinology & Metabolism

A clinical approach to parasellar lesions in the transition age

Emilia Sbardella et al.

Summary: This study provides an overview of the principal parasellar lesions occurring in the transition age from childhood to adulthood, with symptoms mainly resulting from the mass effect of lesions on nearby structures and anterior pituitary deficits. Parasellar lesions in the transition age mostly include neoplastic lesions such as germinomas, hamartomas, optic gliomas, and rarely inflammatory lesions.

JOURNAL OF NEUROENDOCRINOLOGY (2021)

Add to Collection

Article Pediatrics

Delayed diagnosis of congenital hypopituitarism associated with low socio-economic status and/or migration

Emese Boros et al.

EUROPEAN JOURNAL OF PEDIATRICS (2020)

Add to Collection

Review Endocrinology & Metabolism

The Molecular Basis of Congenital Hypopituitarism and Related Disorders

Louise Cheryl Gregory et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2020)

Add to Collection

Article Multidisciplinary Sciences

Pituitary stalk interruption syndrome is characterized by genetic heterogeneity

Raja Brauner et al.

PLOS ONE (2020)

Add to Collection

Review Medicine, Research & Experimental

Vitamin D and growth hormone in children: a review of the current scientific knowledge

Susanna Esposito et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2019)

Add to Collection

Review Endocrinology & Metabolism

Severe, persistent neonatal hypoglycemia as a presenting feature in patients with congenital hypopituitarism: a review of our case series

Shilpa Mehta et al.

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM (2019)

Add to Collection

Review Endocrinology & Metabolism

The Role of Growth Hormone on Ovarian Functioning and Ovarian Angiogenesis

Jesus Devesa et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Factors Involved in the Functional Motor Recovery of Rats with Cortical Ablation after GH and Rehabilitation Treatment: Cortical Cell Proliferation and Nestin and Actin Expression in the Striatum and Thalamus

Margarita Heredia et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Add to Collection

Review Endocrinology & Metabolism

The Concept of Growth Hormone Deficiency Affecting Clinical Prognosis in IVF

John L. Yovich et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

Add to Collection

Article Obstetrics & Gynecology

Congenital Hypopituitarism

John S. Parks

CLINICS IN PERINATOLOGY (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Growth Hormone (GH) and Rehabilitation Promoted Distal Innervation in a Child Affected by Caudal Regression Syndrome

Jesus Devesa et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Add to Collection

Article Endocrinology & Metabolism

Guidelines for Growth Hormone and Insulin-Like Growth Factor-I Treatment in Children and Adolescents: Growth Hormone Deficiency, Idiopathic Short Stature, and Primary Insulin-Like Growth Factor-I Deficiency

Adda Grimberg et al.

HORMONE RESEARCH IN PAEDIATRICS (2016)

Add to Collection

Review Endocrinology & Metabolism

ACTH Stimulation Tests for the Diagnosis of Adrenal Insufficiency: Systematic Review and Meta-Analysis

Naykky Singh Ospina et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2016)

Add to Collection

Review Medicine, General & Internal

Hypopituitarism

Claire E. Higham et al.

LANCET (2016)

Add to Collection

Article Medicine, General & Internal

Learning and Memory Recoveries in a Young Girl Treated with Growth Hormone and Neurorehabilitation

Jesus Devesa et al.

JOURNAL OF CLINICAL MEDICINE (2016)

Add to Collection

Article Biochemistry & Molecular Biology

Brain Recovery after a Plane Crash: Treatment with Growth Hormone (GH) and Neurorehabilitation: A Case Report

Jesus Devesa et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

Add to Collection

Editorial Material Pediatrics

Re-Evaluating Transitional Neonatal Hypoglycemia: Mechanism and Implications for Management

Charles A. Stanley et al.

JOURNAL OF PEDIATRICS (2015)

Add to Collection

Article Endocrinology & Metabolism

Effects of Long-term Growth Hormone Replacement in Adults With Growth Hormone Deficiency Following Cure of Acromegaly: A KIMS Analysis

Nicholas A. Tritos et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2014)

Add to Collection

Article Endocrinology & Metabolism

Diagnostic pitfalls in the assessment of congenital hypopituitarism

Paolo Cavarzere et al.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2014)

Add to Collection

Article Health Care Sciences & Services

Effects of recombinant growth hormone (GH) replacement and psychomotor and cognitive stimulation in the neurodevelopment of GH-deficient (GHD) children with cerebral palsy: a pilot study

Jesus Devesa et al.

THERAPEUTICS AND CLINICAL RISK MANAGEMENT (2011)

Add to Collection

Article Endocrinology & Metabolism

Rational Approach to the Diagnosis of Severe Growth Hormone Deficiency in the Newborn

G. Binder et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2010)

Add to Collection

Article Endocrinology & Metabolism

Congenital hypopituitarism: clinical, molecular and neuroradiological correlates

Ameeta Mehta et al.

CLINICAL ENDOCRINOLOGY (2009)

Add to Collection

Review Obstetrics & Gynecology

Genetic forms of hypopituitarism and their manifestation in the neonatal period

Kyriaki S. Alatzoglou et al.

EARLY HUMAN DEVELOPMENT (2009)

Add to Collection

Review Endocrinology & Metabolism

Effects of Growth Hormone on Glucose, Lipid, and Protein Metabolism in Human Subjects

Niels Moller et al.

ENDOCRINE REVIEWS (2009)

Add to Collection

Article Endocrinology & Metabolism

Developmental disorders of the hypothalamus and pituitary gland associated with congenital hypopituitarism

Ameeta Mehta et al.

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2008)

Add to Collection

Article Pediatrics

Continuous growth reference from 24th week of gestation to 24 months by gender

Aimon Niklasson et al.

BMC PEDIATRICS (2008)

Add to Collection

Article Endocrinology & Metabolism

Hypopituitarism oddities: Congenital causes

Daniel Kelberman et al.

HORMONE RESEARCH (2007)

Add to Collection

Article Endocrinology & Metabolism

An update on the biochemical diagnosis of congenital ACTH insufficiency

A Mehta et al.

CLINICAL ENDOCRINOLOGY (2005)

Add to Collection

Article Endocrinology & Metabolism

Physiological and molecular characteristics of rat hypothalamic ventromedial nucleus glucosensing neurons

L Kang et al.

DIABETES (2004)

Add to Collection

Article Endocrinology & Metabolism

In vivo measurements of brain glucose transport using the reversible Michaelis-Menten model and simultaneous measurements of cerebral blood flow changes during hypoglycemia

IY Choi et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2001)

Add to Collection

Delayed Diagnosis of Congenital Combined Pituitary Hormone Deficiency including Severe Growth Hormone Deficiency in Children with Persistent Neonatal Hypoglycemia-Case Reports and Review

Related references

Export Citation

Share Paper