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Development of Tetrahydroisoquinoline-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities
Yingjie Zhang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Design, Synthesis, Docking, and Biological Evaluation of Novel Diazide-Containing Isoxazole- and Pyrazole-Based Histone Deacetylase Probes
Raghupathi Neelarapu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Histone deacetylases 1, 6 and 8 are critical for invasion in breast cancer
Soon Young Park et al.
ONCOLOGY REPORTS (2011)
Histone Deacetylase: A Potential Therapeutic Target for Fibrotic Disorders
Maoyin Pang et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)
An Acetylation Switch Modulates the Transcriptional Activity of Estrogen-Related Receptor α
Brian J. Wilson et al.
MOLECULAR ENDOCRINOLOGY (2010)
Abrogation of TGF-β1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition
Weichao Guo et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2009)
Combining Mass Spectrometry and Peptide Arrays to Profile the Specificities of Histone Deacetylases
Zachary A. Gurard-Levin et al.
CHEMBIOCHEM (2009)
Azetidinones as Zinc-Binding Groups to Design Selective HDAC8 Inhibitors
Paola Galletti et al.
CHEMMEDCHEM (2009)
Histone Deacetylase 8 in Neuroblastoma Tumorigenesis
Ina Oehme et al.
CLINICAL CANCER RESEARCH (2009)
Targeting of HDAC8 and investigational inhibitors in neuroblastoma
Ina Oehme et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2009)
HDAC inhibitor trichostatin A-inhibited survival of dopaminergic neuronal cells
Yong Wang et al.
NEUROSCIENCE LETTERS (2009)
Structural Studies of Human Histone Deacetylase 8 and Its Site-Specific Variants Complexed with Substrate and Inhibitors
Daniel P. Dowling et al.
BIOCHEMISTRY (2008)
Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin
Fang Liu et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2008)
A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas
S. Balasubramanian et al.
LEUKEMIA (2008)
Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex
Alessandro Vannini et al.
EMBO REPORTS (2007)
Factors affecting the substrate specificity of histone deacetylases
Daniel Riester et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: Multiple mechanisms of action
Hyeon Ju Kim et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)
Sodium valproate exerts neuroprotective effects in vivo through CREB-binding protein-dependent mechanisms but does not improve survival in an amyotrophic lateral sclerosis mouse model
Caroline Rouaux et al.
JOURNAL OF NEUROSCIENCE (2007)
Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors
Keris KrennHrubec et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Structural requirements of HDAC inhibitors: SAHA analogs functionalized a lacent to the hydroxamic acid
Anton V. Bieliauskas et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Distribution of histone deacetylases 1-11 in the rat brain
Ron S. Broide et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2007)
HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates
Cyril Boyault et al.
GENES & DEVELOPMENT (2007)
Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors
G. C. Minetti et al.
NATURE MEDICINE (2006)
Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis
S Camelo et al.
JOURNAL OF NEUROIMMUNOLOGY (2005)
Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases
JR Somoza et al.
STRUCTURE (2004)
The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain
KL Durst et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)