4.7 Review

A Therapeutic Perspective of HDAC8 in Different Diseases: An Overview of Selective Inhibitors

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Potent and Selective Inhibition of Histone Deacetylase 6 (HDAC6) Does Not Require a Surface-Binding Motif

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JOURNAL OF MEDICINAL CHEMISTRY (2013)

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Discovery of the First Histone Deacetylase 6/8 Dual Inhibitors

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JOURNAL OF MEDICINAL CHEMISTRY (2013)

Review Oncology

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JOURNAL OF PATHOLOGY (2013)

Review Cell Biology

HDAC inhibitors in experimental liver and kidney fibrosis

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FIBROGENESIS & TISSUE REPAIR (2013)

Review Chemistry, Medicinal

Towards Isozyme-Selective HDAC Inhibitors For Interrogating Disease

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CURRENT TOPICS IN MEDICINAL CHEMISTRY (2012)

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Chrysin: A Histone Deacetylase 8 Inhibitor with Anticancer Activity and a Suitable Candidate for the Standardization of Chinese Propolis

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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2012)

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HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle

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NATURE (2012)

Review Biochemistry & Molecular Biology

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

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NATURE MEDICINE (2012)

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NMR Profiling of Histone Deacetylase and Acetyl-transferase Activities in Real Time

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ACS CHEMICAL BIOLOGY (2011)

Article Chemistry, Medicinal

Discovery of histone deacetylase 8 selective inhibitors

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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)

Article Biochemistry & Molecular Biology

Acetylation of Heat Shock Protein 20 (Hsp20) Regulates Human Myometrial Activity

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JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

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Histone deacetylases 1, 6 and 8 are critical for invasion in breast cancer

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ONCOLOGY REPORTS (2011)

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Histone Deacetylase: A Potential Therapeutic Target for Fibrotic Disorders

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JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)

Article Endocrinology & Metabolism

An Acetylation Switch Modulates the Transcriptional Activity of Estrogen-Related Receptor α

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MOLECULAR ENDOCRINOLOGY (2010)

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Abrogation of TGF-β1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition

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AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2009)

Article Biochemistry & Molecular Biology

Combining Mass Spectrometry and Peptide Arrays to Profile the Specificities of Histone Deacetylases

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CHEMBIOCHEM (2009)

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Azetidinones as Zinc-Binding Groups to Design Selective HDAC8 Inhibitors

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CHEMMEDCHEM (2009)

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Histone Deacetylase 8 in Neuroblastoma Tumorigenesis

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CLINICAL CANCER RESEARCH (2009)

Review Pharmacology & Pharmacy

Targeting of HDAC8 and investigational inhibitors in neuroblastoma

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EXPERT OPINION ON INVESTIGATIONAL DRUGS (2009)

Article Neurosciences

HDAC inhibitor trichostatin A-inhibited survival of dopaminergic neuronal cells

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NEUROSCIENCE LETTERS (2009)

Article Cardiac & Cardiovascular Systems

Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin

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JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2008)

Article Biochemistry & Molecular Biology

Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex

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EMBO REPORTS (2007)

Article Biochemistry & Molecular Biology

Factors affecting the substrate specificity of histone deacetylases

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

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Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors

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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)

Article Chemistry, Medicinal

Structural requirements of HDAC inhibitors: SAHA analogs functionalized a lacent to the hydroxamic acid

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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)

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Distribution of histone deacetylases 1-11 in the rat brain

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JOURNAL OF MOLECULAR NEUROSCIENCE (2007)

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Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors

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NATURE MEDICINE (2006)

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Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases

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STRUCTURE (2004)

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The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain

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MOLECULAR AND CELLULAR BIOLOGY (2003)