Inflammatory Bowel Disease: A Review of Pre-Clinical Murine Models of Human Disease

Crohn's disease (CD) and ulcerative colitis (UC) are both highly inflammatory diseases of the gastrointestinal tract, collectively known as inflammatory bowel disease (IBD). Although the cause of IBD is still unclear, several experimental IBD murine models have enabled researchers to make great inroads into understanding human IBD pathology. Here, we discuss the current pre-clinical experimental murine models for human IBD, including the chemical-induced trinitrobenzene sulfonic acid (TNBS) model, oxazolone and dextran sulphate sodium (DSS) models, the gene-deficient I-kappa-B kinase gamma (I kappa kappa-gamma) and interleukin(IL)-10 models, and the CD4(+) T-cell transfer model. We offer a comprehensive review of how these models have been used to dissect the etiopathogenesis of disease, alongside their limitations. Furthermore, the way in which this knowledge has led to the translation of experimental findings into novel clinical therapeutics is also discussed.

Automated summary

This article reviews the current murine models used for studying human inflammatory bowel disease, including chemical-induced models, gene-deficient models, and cell transfer models. The application and limitations of these models in understanding the disease pathogenesis and developing new clinical treatment strategies are discussed.