Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 16, Pages -Publisher
MDPI
DOI: 10.3390/ijms23169338
Keywords
obesity; adipose tissue; sexual dimorphism; body fat distribution; cardiovascular diseases
Funding
- Seeding Funds for Basic Research of the University of Hong Kong [17153016, 17124718, 17124420]
- Research Grant Council [C7037-17W]
- University Grants Committee, Health and Medical Research Fund Hong Kong SAR [AoE/M-707/18, HMRF08192306]
- Sun Chieh Yeh Heart Foundation Research Grant
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Body fat distribution is an important predictor of medical outcomes, and it is closely associated with the risks of cardiovascular diseases compared to overall adiposity. The review focuses on the sexual dimorphism, biological clues, and genetic traits that are specific to body fat distribution. Understanding the sex determinations on body fat distribution and obesity is crucial for improving the prevention and treatment of cardiovascular diseases.
Body fat distribution is a well-established predictor of adverse medical outcomes, independent of overall adiposity. Studying body fat distribution sheds insights into the causes of obesity and provides valuable information about the development of various comorbidities. Compared to total adiposity, body fat distribution is more closely associated with risks of cardiovascular diseases. The present review specifically focuses on the sexual dimorphism in body fat distribution, the biological clues, as well as the genetic traits that are distinct from overall obesity. Understanding the sex determinations on body fat distribution and adiposity will aid in the improvement of the prevention and treatment of cardiovascular diseases (CVD).
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