Adipose-Secreted Exosomes and Their Pathophysiologic Effects on Skeletal Muscle

Due to its prominent secretory activity, adipose tissue (AT) is now considered a major player in the crosstalk between organs, especially with skeletal muscle. In which, exosomes are effective carriers for the intercellular material transfer of a wide range of molecules that can influence a series of physiological and pathological processes in recipient cells. Considering their underlying roles, the regulatory mechanisms of adipose-secreted exosomes and their cellular crosstalk with skeletal muscle have received great attention in the field. In this review, we describe what is currently known of adipose-secreted exosomes, as well as their applications in skeletal muscle pathophysiology.

Automated summary

Adipose tissue-secreted exosomes play a significant role in the intercellular communication between organs, especially with skeletal muscle. These exosomes transfer various molecules that can affect the physiological and pathological processes in recipient cells. Therefore, studying the regulatory mechanisms of adipose-secreted exosomes and their cellular crosstalk with skeletal muscle is of great importance.